Microtubule and mitosis dynamics

The paper investigates the mechanical properties of fission yeast spindles by analyzing their response to mechanical and genetic perturbations, revealing their behavior as a rigid beam and identifying key proteins involved in elongation and structural integrity.

The paper shows that cortical F-actin filaments prevent HMR-1 from entering the cytokinetic furrow in C. elegans embryos, revealing a regulatory link between cell adhesion and division.

This study identifies and characterizes two novel TOG domain-containing proteins in C. elegans, showing their role in sperm function and microtubule regulation.

This study identifies MAPKBP1 as a centrosomal protein that forms a complex with WDR62 and CEP170, essential for PCM cohesion and mitotic spindle formation.

This study shows that microtubule lattice defects accelerate spastin-mediated severing by reducing the number of tubulin subunits needed for cleavage, without preferential spastin binding to defects.

This study depletes UNC-116 in C. elegans using auxin-mediated degradation and shows its role in bidirectional DCV transport and locomotion across different timescales.

This study develops a computational model of aneuploid karyotype dynamics in budding yeast, revealing that reversion mechanisms vary by chromosome and can involve coupled nondisjunction and recombination.

This study identifies DYN-1's role in regulating spindle pole organization and midbody assembly in C. elegans by controlling SPD-2 and PLK-1 localization.

The paper investigates the role of α-tubulin helix 11 in tubulin heterodimer conformation and microtubule dynamics, showing its impact on disease and evolutionary conservation.

This study shows that GSK-3β regulates axonal microtubule organisation via Shot and Tau, and misregulation causes microtubule disorganisation linked to neurodegeneration.

The paper investigates how epithelial tissues maintain architecture and cell number despite spindle misorientation, identifying mechanical and systemic signaling mechanisms that prevent cell loss.

The paper identifies tubulins in Asgard archaea and shows they form mini-microtubules with eukaryotic-like properties, suggesting an archaeal origin for microtubules.

This study shows that tubulin acetylation regulates lysosomal reformation and organelle interactions during neuronal differentiation by shaping organelle architecture and spatial distribution.

This study shows that adenovirus E4orf4 interacts with CDC20 to redirect APC/C-CDC20 towards Aurora B, causing hyperubiquitination and mitotic regression, leading to polyploidy.

This study shows that TTF2 removal causes mitotic defects by retaining transcription on chromatin, leading to sister chromatid resolution failure and genome instability.

This paper develops a coarse-grained model to study protofilament clustering at microtubule plus-end tips, showing lattice instability drives PF cluster formation and dynamics.

The paper identifies NDE1 as a synthetic lethal target in metastatic cancer cells driven by chromosomal instability and Chr17p loss.

This study shows Msps/XMAP215 promotes oocyte fate by enhancing microtubule polymerization and Orb accumulation, leading to asymmetric distribution and positive feedback in Drosophila.

This study investigates how KIF7, a non-motile kinesin, uses conserved kinesin principles to function as a scaffold in Hedgehog signaling by regulating GLI transcription factors.

This paper introduces a method to control kinase activity with spatiotemporal precision using conditional localization pharmacology, demonstrating its ability to manipulate the cell cycle.

This study resolves a paradox in spindle length control by showing that coordinated regulation at both microtubule ends allows spindle length and poleward flux to vary independently.

The paper investigates the accessibility of the α-tubulin C-terminal tail (Y-CTT) and finds it is regulated by microtubule lattice conformation through nucleotide state and MAP interactions.

This study identifies septin-associated PIPKIγ splice variants as essential for midbody organization by generating PI(4,5)P2 required for centralspindlin recruitment and septin-microtubule association.

This study investigates the conformational flexibility of kinesin-1 using biophysical methods, revealing its open structure without cargo and insights into autoinhibition.

The paper identifies M18BP1 dimerization and its interaction determinants as key for centromere specification through epigenetic mechanisms in humans.

This study shows Cyclin A2 and B1/B2 have opposing roles in regulating kinetochore dynamics and mitotic progression in human cells.

The paper investigates intracellular transport pauses, finding they are active, motor-driven states rather than passive, and reveals a quantitative relationship between pause diffusivity and run velocity.

The paper shows that microtubule depolymerization at kinetochores limits spindle elongation rather than moving chromosomes apart during anaphase.

This study identifies CFDP1 as a bipartite MAP that promotes spindle assembly by interacting with TPX2 and Aurora A, and facilitating importin dissociation from TPX2.

The paper demonstrates how embryos use microtubule dynamics and temporal control to achieve robust cytoplasmic partitioning through two distinct strategies in zebrafish and Drosophila.