Microtubule and mitosis dynamics

This study shows CDK1-dependent phosphorylation of NuMA's N-terminus is essential for dynein-dynactin-NuMA complex formation, ensuring accurate chromosome segregation.

This study shows TPGS1 regulates polyglutamylation and remodeling of central spindle microtubules during telophase, affecting mitotic cell division completion.

The paper shows that Ska and Ndc80 complexes form oligomers to stabilize microtubule ends during mitosis, with a mutation disrupting Ska:Ska interactions and impairing stability.

The paper investigates how tau protein coordinates microtubule-actin interactions in synthetic cell-like vesicles, showing its role in MT organization and MT-actin colocalization depending on actin crosslinkers and vesicle size.

This study identifies Cep192 insufficiency as a cause of haploid instability in human cells and shows that restoring Cep192 or enhancing the acentrosomal spindle pathway stabilizes haploid cells.

This study uses optogenetics to induce microtubule acetylation and reveals its role in enhancing actomyosin contractility and directed cell migration through GEF-H1 release.

This paper introduces MT-DS, a fluorescent probe that directly visualizes microtubule lattice damage, revealing motor-caused damage during motility.

This study shows that KIF11 mutations impair microtubule dynamics and dendritic arborization in neurons, contributing to intellectual disabilities.

The paper investigates the role of three chromatin-associated PP1 targeting subunits in mitotic exit and G1 re-establishment using multi-omic analyses.

The paper identifies the 53BP1-USP28-p53 pathway as an external mitotic surveillance system that induces post-mitotic arrest when fidelity-ensuring mechanisms are compromised.

The paper shows that spindle elongation rescues polar chromosomes from missegregation by pivoting astral microtubules toward the spindle surface, with implications for chromosomal instability in cancer.

This study investigates how NuMA activates dynein and regulates microtubule dynamics during mitosis using structural and functional analyses.

This study compares mitosis in 3D tumor spheroids and 2D monolayers, finding prometaphase delays and proteomic changes in spheroids.

This study develops a model to analyze how error correction and the spindle assembly checkpoint affect mitotic timing and fidelity in human cells.

This study identifies proteostasis failure and mitochondrial dysfunction as key factors in microcephaly caused by complex aneuploidies in neural stem cells.

This study shows that kinesin-driven microtubule buckling causes severe lattice damage that often exceeds microtubule self-repair capacity, leading to breakage, but survival is enhanced with intracellular factors.

The paper uses live-cell imaging to show that GTP-cap size decreases during mitosis, modulating microtubule stability in a cell-cycle-dependent manner.

The paper develops a mathematical model to show that Rim4 degradation and Ama1 translation are essential for irreversible meiotic exit in budding yeast.

The paper uses zebrafish otic vesicles and mouse epididymis to study columnar epithelial cell division dynamics, revealing conserved and species-specific mechanisms of nuclear migration and division.

This study investigates the bidirectional motility of Cin8 kinesin-5 dimers, finding a plus-end bias and weak inter-head coordination, suggesting directional switching is regulated by coordination levels.

The paper examines centromere protein dynamics during quiescence entry and exit, showing rapid disassembly and reassembly of centromere proteins with specific timing for CENP-A deposition.

This study shows that Wnt signaling controls abscission dynamics in mouse embryonic stem cells by regulating Aurora B activity and microtubule stability at the intercellular bridge.

This study shows that TTLL6 disrupts microtubule dynamics and that LDC10 inhibits TTLL activity and reverses TTLL6's effects.

This study shows that septin complexes in Drosophila regulate microtubule organization and synaptic function at neuromuscular junctions by stabilizing microtubules and affecting vesicle recycling.

The paper identifies the molecular mechanism by which Nesprin-2 interacts with Bicaudal D2 to recruit dynein for nuclear positioning during brain development.

This study shows that Sgo1 inhibits APC/C to prevent separase activation during mitosis but enhances Rec8 cohesin protection during meiosis through its D-box.

The paper shows that cell confinement causes delayed, heritable chromosome loss, which is linked to mitotic memory and has implications for cancer evolution.

This study uses cryo-EM to reveal structural mechanisms of KMN complex assembly and phospho-regulation in budding yeast kinetochores.

This study shows that neuronal kinesin-1 (KIF5C) forms tetramers through dimer-dimer association, with conformational activation promoting this higher-order assembly.

This study identifies ARK1 as a critical regulator of mitosis in Plasmodium, forming a non-canonical chromosomal passenger complex with divergent INCENPs, and highlights its potential as an antimalarial target.