Microtubule and mitosis dynamics

This paper shows Survivin is required for HeLa cells to enter mitosis, as its absence causes early prophase arrest and mitotic defects through disruption of the Cdk1-Cdc25B axis.

This paper identifies two conformations of the γ-tubulin ring complex (γ-TuRC) using cryo-EM and proposes a model for how conformational changes facilitate microtubule nucleation.

The paper describes the structure of the budding yeast outer kinetochore complexes and how phosphorylation regulates their stability during mitotic error correction.

This study shows that NF1 loss increases sensitivity to the ADC T-DM1 by modulating microtubule repair and dynamics, identifying NF1 as a predictive biomarker for ADC response.

The paper reports cryo-EM structures of human α1B/βI+βIVb microtubules in GDP and GTP-like states, revealing isoform-specific sequence variations affecting polymerization interfaces and microtubule dynamics.

This study shows that CENP-C must be expressed during meiotic prophase to ensure proper chromosome segregation, unlike CID which remains stable without prophase expression.

The paper uses TIRFM to study dynein-dynactin motility in human cells, finding fast processive movement with specific velocity and run length characteristics.

This study identifies CEP44's role in preventing centriole overduplication and maintaining spindle integrity, linking it to breast carcinoma prognosis.

The paper identifies CDKB1 and CYCB3;1 as regulators of spindle architecture in Arabidopsis, showing their role in modulating the augmin pathway through phosphorylation of EDE1.

This study shows that LXY18 selectively kills MYC-overexpressing cancer cells by inducing mitotic arrest, offering a new approach to target MYC-driven tumors.

The paper shows that disrupting the balance of microtubule tyrosination and detyrosination in neurons leads to defects in axonal transport and AIS length.

The paper shows that topological spindle-spindle interactions, not internuclear distance, control spindle orientation and nuclear fate in Drosophila embryos.

This study shows FMNL2 regulates actin dynamics, spindle migration, and organelle distribution in mouse oocytes, essential for polar body extrusion and meiosis.

The paper identifies a conserved arginine residue in the Dam1 complex subunit Dad2 that is essential for viability in yeast but less so in fungi with regional centromeres, suggesting functional plasticity in chromosome-microtubule coupling.

The paper presents a structural and functional analysis of the KMN network, revealing key interfaces and their role in stabilizing microtubule binding and force transmission during chromosome segregation.

The paper shows that yeast cells with impaired early anaphase Cdc14 release can complete meiosis without ribosomal DNA disjunction in meiosis I, suggesting this process is not essential for meiosis.

This study identifies Dunk as a regulator of myosin II during Drosophila cellularization by interacting with anillin to control its localization and function.

The paper shows that HDAC1 regulates α-tubulin acetylation in response to nutritional stress, affecting microtubule dynamics and mRNP transport in Drosophila germline cells.

The paper identifies CEP192 as a novel disease gene linked to mosaic variegated aneuploidy syndrome with tetraploidy and male infertility through genetic analysis and mouse models.

The paper presents the high-resolution structure of a microtubule-like tube formed by FtsZ-monobody complexes, revealing structural similarities to microtubules and the role of FtsZ protofilament plasticity.

This study investigates the role of HpCTCF in sea urchin early development, showing it is essential for mitotic progression but not for later larval development.

The paper maps centriolar and PCM core protein localization in C. elegans post-embryonic lineage, showing cell fate determines centriole retention.

The paper investigates the role of the 5' intron in TUB1 gene regulation in S. cerevisiae, showing it enhances -tubulin expression and cell fitness during microtubule stress.

The paper shows that controlled PP1 activity oscillations are essential for proper meiotic progression in mouse oocytes, with disruptions causing severe meiotic defects.

This study identifies Kinesin-1's role in centrosome clustering and nuclear migration in Drosophila oocytes by showing its impact on centrosome activity and positioning.

This paper shows that Cdc48 and Ufd1 remove excess CENP-A from chromatin in fission yeast, maintaining proper centromere function and preventing chromosome missegregation.

This study shows that a sas-6(L69T) mutation in C. elegans disrupts centrosome duplication, ciliogenesis, and dendrite morphogenesis, contributing to microcephaly mechanisms.

The paper identifies 65 novel meiotic and fertility genes in Drosophila melanogaster through RNAi screening, showing their role in infertility and chromosomal nondisjunction.

This study identifies NSD3 as a regulator of cohesin loading during mitotic exit, showing its interaction with kollerin and its role in sister chromatid cohesion.