Ion channel regulation and function

The paper identifies a specialized ER compartment that sequesters hERG1b subunits, enabling post-translational heteromeric assembly with hERG1a instead of degradation.

This study introduces a Gauss-Nernst-Planck approach to analyze how electrodiffusive dynamics influence ion channel rectification and neural activity, revealing new insights into membrane conductivity and neural firing mechanisms.

The paper shows that mechanosensitive channels in prokaryotes, like E. coli, mediate copper influx, challenging the idea that cytoplasmic copper uptake is unnecessary in these organisms.

The paper presents a structural model of the closed Shaker potassium channel, revealing how voltage sensor movement drives pore opening and identifies a binding site for dalfampridine.

This paper uses molecular dynamics simulations to study the asymmetric opening of MscL mutants under tension, revealing the S1 state and its free energy profile.

This study identifies Tse4 as a pore-forming toxin that forms ion-selective channels, linking membrane depolarisation to K+ efflux in competing bacteria.

This study investigates the impact of the Kir4.2R28C mutation on channel function and cellular processes, finding it causes loss of function and disrupts protein stability and trafficking.

This study uses molecular dynamics simulations to reveal the three-ion knock-on mechanism governing calcium ion permeation and valence selectivity in CaV1 channels.

This study presents cryo-EM structures of human NCX1 with PIP2 and SEA0400, revealing how these molecules modulate NCX1 activity through conformational changes.

This study investigates how disease-associated Kv1.3 variants affect protein folding and stability, finding that R114G variant shows reduced folding probability and structural instability.

This paper improves molecular dynamics simulations of potassium channels by incorporating polarization effects, achieving accurate predictions of conductance, ion occupancy, voltage response, and selectivity.

This study identifies the C-terminal domain as the temperature sensor in TREK channels and shows that microtubule interaction and PKA phosphorylation regulate their thermosensitivity.

The paper uses cryo-EM to show that hyperpolarization-induced displacement of the S4 helix in Kv2.1 channels causes pore constriction by altering interactions with S6 helices, similar to EAG1 channels.

This paper reports the cryo-EM structure of the human TWIK-2 potassium channel and shows that pimozide inhibits it by displacing acyl chains and blocking ion conduction.

The paper investigates how rhythmogenic ionic currents and ion channel expression in spinal Shox2 interneurons change during postnatal development in mice.

The paper elucidates the structural mechanism of RyR channel operation by Ca2+ and Mg2+ ions using bioinformatics and statistical modeling.

The paper investigates how mutations in BK channel β subunit residues affect inactivation by altering access to the central cavity through the side portal pathway.

This study investigates the structural dynamics of CaV2.1 voltage-sensor domains and their role in voltage-dependent inactivation and synaptic function.

This study shows that BEST1, a chloride channel, is directly activated by extracellular GABA, with structural and functional evidence revealing the mechanism of GABA-induced channel opening.

This study shows that a single mutation can drastically alter the temperature response of Kv channels by modifying their electromechanical coupling.

This study shows tofogliflozin induces vasodilation in rabbit arteries by activating Kv channels, the SERCA pump, and the sGC/cGMP pathway, independent of endothelium or PKA.

This study investigates the role of the SLO2.1/NALCN complex in regulating mouse myometrial smooth muscle cell membrane potential across pregnancy, finding its activity decreases as pregnancy progresses.

The paper investigates the cotranslational membrane insertion of the KvAP voltage-sensitive ion channel using Force Profile Analysis, revealing three distinct insertion steps and the role of charged residues and helical structures.

The paper identifies a novel KATP channel pharmacochaperone, Aekatperone, using AI screening and cryoEM, showing reversible inhibition and functional recovery of trafficking mutants.

This study shows that ERG1A overexpression in C2C12 myotubes reduces calsequestrin1 levels, leading to increased intracellular calcium concentration through modulation of calcium buffering.

This paper uses multiscale responsive kinetic modeling to study ion channel mechanisms, showing that off-pathway flux and dielectric screening significantly influence current profiles and channel behavior.

The paper shows that SNARE complex proteins inhibit NALCN channel activity and that reducing NALCN currents promotes cell survival in syntaxin-depleted cells.

The paper identifies Kir7.1 as the target of steroids regulating uteroplacental function, showing its activation by progesterone and labor-prevention drugs.

The paper identifies a conserved motif in HCN4 channels that mediates heat sensing and modulates heart rate responses to thermal energy.

The paper identifies and functionally characterizes voltage-gated K+ channels in ctenophores, showing independent evolution of diverse subtypes similar to those in cnidarians and bilaterians.