Fungal and yeast genetics research

Ktd1 is a phospho-regulated member of the Dup240 family that mediates defence against killer toxin K28

This study identifies Ktd1 as a phospho-regulated member of the Dup240 family essential for defense against the K28 killer toxin in yeast.

Fss1, a CTNS/PQ domain protein, has dual roles in promoting fertility in Schizosaccharomyces pombe

Fission yeast Fss1, a PQ-loop membrane protein, acts in diploids to build full-thickness, chitin-containing spore walls and within spores to maintain vacuole morphology and timely germination.

Sugar-induced cell death in exponentially growing yeast depends on the functionality of the nonoxidative branch of the pentose phosphate pathway.

oidyPeaks: R package for automated flow cytometry cell cycle analysis and visualization in fungal microbes

The paper introduces an R package for automated flow cytometry analysis of fungal cell cycle and karyotypic subpopulations, demonstrating its utility on evolving Candida albicans populations.

The lipid raft marker flotillin FloA drives relocalization of the plasma membrane H+-ATPase PmaA as a protective response to calcium stress

This paper shows that FloA, a flotillin in Aspergillus nidulans, is required for the internalization of PmaA during calcium stress, preventing calcium overload and promoting cell survival.

Multicellularity and virulence in the budding yeast, Saccharomyces cerevisiae

The paper investigates multicellular traits in Saccharomyces cerevisiae, finding significant variation and genetic architecture, with some genes linked to virulence in larvae.

Synthetic collinearization of a chromosome segment enables genetic dissection of incompatibility between distant genera

This paper demonstrates that collinearization can overcome genetic incompatibility between distant yeast species by creating synthetic chromosome segments that substitute for native ones, revealing hundreds of genetic incompatibilities.

A single meiotic product dominates inheritance in Mucor circinelloides

The paper shows that meiosis in Mucor circinelloides produces genetically uniform progeny from a single meiotic product, unlike conventional meiosis.

Analysis of genome sequences of marine isolates of Saccharomyces cerevisiae

The paper reports the genome sequences of three marine Saccharomyces cerevisiae strains and assesses their salt and inhibitor tolerance compared to terrestrial strains.

Universal principles of protein resource allocation among cellular organelles revealed by yeast large-scale absolute quantitative proteomics

This study uses yeast large-scale absolute quantitative proteomics to reveal universal principles of protein resource allocation among cellular organelles and its relationship to physiological parameters and species divergence.

UV-induced translation capacity is regulated developmentally in fungi.

This study shows UV radiation increases ribosome levels and translation capacity in filamentous fungi after filament formation, enhancing UV survival and repair through mechanisms involving TOR signaling and gene expression modules.

Ribosomal biogenesis factor links ribosome homeostasis to host relevant stress survival in Aspergillus fumigatus

This study shows that BFR2, a ribosomal biogenesis factor in A. fumigatus, is crucial for fungal stress survival and virulence, linking ribosome function to host-mediated stress resistance.

A reproductive hierarchy controls mating fates among sibling yeast gametes

The paper quantifies mating strategies in yeast gametes, revealing a reproductive hierarchy where sibling gametes have divergent mating trajectories and temporal heterogeneity shapes compatibility.

Regulation of polarity during morphological transitions in Aureobasidium pullulans

This study investigates the regulation of cell polarity during morphological transitions in Aureobasidium pullulans, showing that Rac1 and Cdc42 have distinct roles in different growth modes.

A nematode-trapping fungus orchestrates polarity cues, septins, and NOX signaling for trap formation

This study identifies molecular mechanisms coordinating cell polarity, septins, and NOX signaling in nematode-trapping fungi for trap formation.

Coordinated GlcNAc transport couples nutrient acquisition to invasive growth and virulence in Candida albicans

This study identifies Hgt1 and Ngt1 as GlcNAc transporters in C. albicans that coordinate nutrient uptake with invasive growth and virulence.

Evolutionary insights into an ancient fungal transition from land to sea

This study investigates the evolutionary transition of fungi from land to sea using Kluyveromyces yeasts, finding genome size reduction, phenotypic changes, and positive selection in marine species.

Salt-enhanced surface display in the halotolerant yeast Debaryomyces hansenii

This paper develops genetic tools for surface display in the halotolerant yeast Debaryomyces hansenii, enabling enzyme activity under hypersaline conditions.

Pre-neuronal origins of monoamine and acetylcholine synthesis and transport

This study identifies the evolutionary origins of neurotransmitter synthesis and transport in fungi, showing these functions predate neurons and are linked to lysosomal processes in opisthokonts.

The Genetic Landscape of Structural Variants in Aspergillus flavus using ONT and PacBio Sequencing

This study uses long-read sequencing to analyze structural variants in Aspergillus flavus, identifying homopolymer tracts and deletions that arise spontaneously.

Cheese adaptation beyond Penicillium: contrasting genomic trajectories in the distantly related Nectriaceae molds

This study compares genomic adaptations of cheese-associated Nectriaceae fungi, revealing contrasting evolutionary paths involving gene family expansions, reductions, and horizontal gene transfer.

Recombination persists near the mating-type locus in pseudo-homothallic Cladorrhinum fungi (Sordariales)

The paper investigates recombination near the mating-type locus in Cladorrhinum fungi, finding no evidence of large recombination suppression despite pseudo-homothallic life cycles.

A membrane-free spot-plating protocol for Agrobacterium-mediated transformation of diverse yeasts

This paper introduces a membrane-free spot-plating protocol for Agrobacterium-mediated transformation of diverse yeasts, improving efficiency and reducing costs.

Distinct metabolic states of yeast and pseudohyphae differentially prime innate immune responsiveness

This study compares metabolic states of yeast and pseudohyphae in Malassezia furfur, showing how they differentially influence innate immune responses through extracellular metabolic environments.

Regulation of polyphosphate homeostasis in S. cerevisiae by the Sky1 protein kinase

This study identifies Sky1 as a regulator of polyphosphate homeostasis in yeast, showing its role in controlling polyP levels and linking it to potassium homeostasis and gene expression.

Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus

This study shows that endosome motility in Aspergillus species affects light-responsive development and secondary metabolite production.

Deconstruction of Saccharomyces hybrids reveals multiple genomic regions required for thermotolerance

This study identifies genomic regions in Saccharomyces hybrids that contribute to thermotolerance by analyzing chromosome elimination and CRISPR-Cas9-induced loss of heterozygosity.

PAK-family kinases promote cell fusion irreversibility by preventing cell wall repair

This study shows PAK-family kinases prevent cell wall repair after fusion, ensuring irreversibility in fission yeast.

Ectopic overproduction of cell wall glucan through membrane perturbation by an antifungal peptide theonellamide A in fission yeast

This study shows that the antifungal peptide TNM-A causes ectopic overproduction of cell wall glucan in fission yeast by altering Cdc42 activation and glucan synthase localization.

Non-coding RNAs drive transcriptional network rewiring underlying thermal dimorphism in a human pathogenic fungus