Fungal and yeast genetics research

This paper shows that FloA, a flotillin in Aspergillus nidulans, is required for the internalization of PmaA during calcium stress, preventing calcium overload and promoting cell survival.

This paper demonstrates that collinearization can overcome genetic incompatibility between distant yeast species by creating synthetic chromosome segments that substitute for native ones, revealing hundreds of genetic incompatibilities.

This study uses yeast large-scale absolute quantitative proteomics to reveal universal principles of protein resource allocation among cellular organelles and its relationship to physiological parameters and species divergence.

This study shows UV radiation increases ribosome levels and translation capacity in filamentous fungi after filament formation, enhancing UV survival and repair through mechanisms involving TOR signaling and gene expression modules.

This study identifies molecular mechanisms coordinating cell polarity, septins, and NOX signaling in nematode-trapping fungi for trap formation.

This paper introduces a membrane-free spot-plating protocol for Agrobacterium-mediated transformation of diverse yeasts, improving efficiency and reducing costs.

This study shows that endosome motility in Aspergillus species affects light-responsive development and secondary metabolite production.

This study shows PAK-family kinases prevent cell wall repair after fusion, ensuring irreversibility in fission yeast.

This study shows that the antifungal peptide TNM-A causes ectopic overproduction of cell wall glucan in fission yeast by altering Cdc42 activation and glucan synthase localization.

The paper shows that RNase T2-mediated RNA degradation is essential for maintaining phosphate homeostasis in S. cerevisiae, even under phosphate-replete conditions.

This study identifies Mig3 as a redundant CCR repressor in fungi, showing its essential role in regulating mitochondrial and ribosomal gene expression alongside Mig1.

The paper uses single-cell imaging and machine learning to show Bck2 is critical for yeast cell size adaptation to nutrient changes, unlike in steady-state conditions.

This study shows that phosphate availability influences cell wall remodeling in C. albicans under oxidative stress, linking nutrient sensing to fungal mechanical resilience.

The paper examines how organelle content scales with cell volume in a fungus with a large size range, finding that some organelles scale with volume while others do not.

The paper studies organelle inheritance in the multi-budding yeast Aureobasidium pullulans, finding that some organelles are evenly distributed while others are variably inherited.

The paper identifies a transcription factor in Rhodotorula toruloides that specifically inhibits glucose-mediated repression of disaccharide utilization, revealing a tailored carbon catabolite repression mechanism.

This study identifies and characterizes chitin synthase genes in the chytrid fungus Rhizoclosmatium globosum, revealing their expression patterns and localization during development.

This study identifies evolutionary patterns of gene gain and loss in fission yeasts, revealing how metabolic genes contribute to diversification and link carbon metabolism to sexual reproduction.

The paper uses machine learning to predict yeast fitness across 35 environments using genetic variants, finding that copy number variants explain most fitness variation and that gene contributions depend on isolate and environment.

The paper identifies 21 core WD40 genes in Fusarium graminearum through phenome analysis of deletion mutants, linking them to virulence and sexual reproduction.

The paper examines regulatory divergence in Saccharomyces yeasts and finds that while cis and trans regulatory effects are widespread, hybrid gene expression remains largely conserved due to compensatory divergence.

The paper identifies genetic factors that allow Cryptococcus neoformans to grow without the core septin Cdc12, revealing compensatory mechanisms for septin-independent cell integrity.

This study investigates heme transfer in Candida albicans using fluorescent hemophore fusions, revealing distinct kinetic mechanisms for heme acquisition and transfer between hemophores.

The paper identifies SmDOC1/2 as regulators of the MAK2 pathway in Sordaria macrospora, showing non-redundant roles in sexual development through proximity mapping and genetic analysis.

This study identifies Ghs2 as a binding partner of Bgs3 in fission yeast, showing they co-localize and work together to synthesize and branch β-1,3-glucan in the fungal cell wall.

This paper establishes a haploid yeast strain collection to study ecological and reproductive divergence in wild S. cerevisiae, finding that structural genomic variation and metabolic gene divergence drive these traits.

The paper expands and optimizes the AID2 system for use in Candida species, including clinical isolates and C. auris, enhancing its utility for protein function studies.

This paper repurposes the native non-homologous end joining (NHEJ) bias in Wickerhamomyces ciferrii to create a multicopy genome integration platform for metabolic engineering.

This study identifies conditions for observing sulfide-induced invasive growth in wine yeast and shows genetic and environmental factors influence this behavior.