Fungal and yeast genetics research

The paper investigates the long-term stability of heterologous protein antigens in yeast cells and proposes a strategy to assess their integrity.

This study compares kinomes of 12 Fusarium oxysporum isolates and seven ascomycete genomes, identifying kinase expansions linked to environmental sensing and host specificity.

The paper generates an ORFeome collection and associated tools for studying Candida albicans pathogenesis.

The paper investigates cell-to-cell variation in yeast by analyzing the impact of gene deletions on mitochondrial state and its effects on proliferation, drug resistance, and mutation outcomes.

This study shows that Candida albicans rapidly generates genotypic and phenotypic diversity in the mouse oral cavity, with higher mutation rates compared to in vitro conditions.

The paper identifies a regulatory network involving MAP-Kinase pathways and transcription factors that maintain cell integrity and mediate communication and cell fusion in Neurospora crassa.

The paper identifies secreted and cell membrane proteins in ten Aspergillus species and finds their secretomes are more antigenic and structurally similar to known drug targets.

The paper sequences and assembles the genome of Candida albicans ATCC 10231, identifying genomic variations linked to responses to fluconazole, pH, and non-invasive growth.

This study reports the whole genome sequence of Cordyceps guangdongensis, providing genomic resources for further genetic and biological research.

The paper links gene expression variation to a stress defense trait in yeast by identifying a QTL hotspot locus affecting ethanol-induced cross protection.

The paper maps meiotic recombination in Cryptococcus deneoformans, finding lower recombination rates in unisexual reproduction compared to bisexual crosses.

The paper shows that fructophilic yeasts in the W/S clade lost and reacquired alcoholic fermentation genes via horizontal gene transfer, adapting to high sugar environments.

The paper develops a high-throughput genetics method for Rhodosporidium toruloides, identifies essential genes, and reveals key processes in lipid metabolism.

The paper analyzes genome data from dimorphic fungi to identify evolutionary mechanisms underlying their adaptation to human hosts.

The paper identifies gene clusters in fungal genomes associated with phenylpropanoid degradation and links their organization to ecological lifestyles.

The paper investigates how gene expression changes during heat shock adaptation in yeast are constrained by metabolic requirements and shows these changes are specific to heat shock.

This study shows that the INO80 chromatin-remodelling complex coordinates metabolic homeostasis with cell division in S. cerevisiae by regulating periodic gene expression.

The paper quantifies mutation effects on TDH3 promoter activity in yeast across environments and finds natural selection limits plasticity between glucose and galactose.

The paper uses single-cell RNA-seq to study stress response heterogeneity in yeast, finding regulatory variation and decoupled transcription-factor activation.

This study maps cis-regulatory variation in budding yeast with high-resolution eQTLs, revealing roles of non-promoter variants and selection pressures on gene expression.

The paper identifies non-catalytic phenotypes in yeast enzymes, suggesting moonlighting activities beyond their annotated functions.

The paper analyzes RNA-seq data from Schizophyllum commune to show that spontaneous mutations accumulate during strain preservation, with a mutation rate of 1.923×10^-8 per haploid genome per base per generation.

The paper re-analyzes gene deletion data in yeast to show that Htz1 and Set1 regulate ergosterol levels and stress response genes through epigenetic crosstalk.

The paper constructs a network of reactions for plant cell wall polysaccharide degradation in Neurospora crassa by integrating multiple data types and identifies a key transcription factor in mannan degradation.

The paper uncouples glucose sensing from metabolism in yeast by using a cellobiose pathway, revealing new regulatory mechanisms for ATP management and energy homeostasis.

The paper examines meiotic recombination differences between Saccharomyces cerevisiae and Lachancea kluyveri, finding significant variations in recombination rates, crossover patterns, and hotspot conservation across evolutionary distances.

The paper identifies a chromosomal duplication in yeast that enhances tolerance to oxidative stress by duplicating the TSA2 gene.

This study develops a yeast-based chemical-genetic screening system to annotate compound functionality across biological processes and identifies compounds with dual modes of action.

This study evolves Candida albicans under hypoxia and heat shock, finding nuclear genome variants and reduced mtDNA methylation without mtDNA sequence changes.

The paper presents a high-quality genome assembly of Trichoderma reesei QM6a, reveals new sequences and AT-rich blocks, and demonstrates repeat-induced point mutation mechanisms.