Judith G. Berman

J-AST is a web-based platform for analyzing antimicrobial susceptibility tests, providing automated annotation and MIC detection with high agreement with manual methods.

This study shows that quiescence in Candida albicans enhances survival during antifungal drug exposure by altering cellular properties and gene expression.

This study shows that fluconazole tolerance in fungi is linked to decreased cytoplasmic fluidity and increased heterogeneity, mediated by changes in ribosome dynamics and P-body formation.

This study identifies Mnl1 as a repressor of azole tolerance in Candida albicans by linking it to sphingolipid metabolism, mitochondrial activity, and PKA signaling.

This study identifies 34 drugs that affect antifungal efficacy in Candida albicans, with some promoting resistance when combined with fluconazole.

This study uses AlphaFold2 to analyze how metabolism influenced enzyme structural evolution across 400 million years by examining 11,269 enzyme structures and their metabolic reactions.

The paper identifies a non-genetic, heritable mechanism of drug resistance in Candida albicans triggered by subtherapeutic fluconazole exposure, which can be reversed and involves prion-like epigenetic processes.

This study shows how azole resistance in Candida albicans evolves through copy number variation followed by KSR1 loss of heterozygosity, resulting in a >500-fold resistance increase.

The paper quantifies proteomic effects of aneuploidy in natural yeast isolates, finding chromosome-wide dosage compensation in the proteome but not transcriptome.

This study evaluates the fitness costs and benefits of trisomy in Candida albicans across various stress conditions, finding that specific aneuploids confer growth advantages under host-relevant stresses.

The paper identifies essential genes and fluconazole resistance genes in Candida glabrata using Hermes transposon insertion profiling and machine learning.

The paper compares transposon mutagenesis methods in yeast to infer gene essentiality, finding biases in insertion sites and recommending transposon choices for accurate essentiality prediction.

The paper presents the first genome-wide chromatin profiling of histone modifications in Candida albicans, linking chromatin structure to gene expression and identifying roles of chromatin modifiers.

The paper shows that trisomy of chromosomes 5 or 6 in Candida albicans during oropharyngeal infection leads to a commensal-like phenotype with reduced virulence.

This paper identifies autonomously replicating linear plasmids in Candida albicans and shows that chromosomal origin sequences can drive plasmid replication.

This study shows that Candida albicans rapidly generates genotypic and phenotypic diversity in the mouse oral cavity, with higher mutation rates compared to in vitro conditions.

The paper predicts microbial relative growth in mixed cultures using growth curve data and validates it with E. coli experiments.