Adipokines, Inflammation, and Metabolic Diseases

This study shows that macrophage PARP1 depletion disrupts adipose tissue homeostasis by enhancing cell-cell crosstalk, leading to obesity and metabolic dysfunction.

A dietary intervention after stopping incretin analog therapy restores adipose tissue function and prevents weight regain in diet-induced obese mice.

This study shows that deleting Dbc1 in adipocytes does not cause healthy obesity but reveals a role for Dbc1 in inflammation during obesity.

The paper identifies a set of genes whose expression predicts obesity susceptibility before symptoms appear, validated across species and tissues.

This study investigates the functional differences between thymic and peripheral Treg cells in visceral adipose tissue, showing that tTreg instability contributes to inflammation and obesity while pTreg cells protect against metabolic disorders.

This study shows weight loss in mice induces adipose macrophage memory that enhances local Staphylococcus aureus clearance but correlates with worsened diabetes risk upon weight regain.

This study identifies sex-specific differences in VEGF and PDGF ligand and receptor profiles in adipose tissue during obesity progression and weight loss using a mouse model.

The paper models metabolic disease susceptibility and resilience in genetically diverse mice by analyzing diet-induced metabolic responses across three strains.

This study shows that inhibiting 12-LOX improves glucose homeostasis and reduces obesity-related inflammation in human gene replacement mice.

This study shows that MRP8-Cre mice have off-target deletions affecting genes involved in thromboinflammation and metabolism, making them unsuitable for studying weight gain and metabolic disorders.

This study reviews and meta-analyzes 60 articles to assess if circulating irisin levels are linked to type 2 diabetes, finding inconsistent results and a trend of lower irisin in T2DM patients.

This study shows that miR-802 in adipose tissue promotes inflammation and insulin resistance by modulating macrophage recruitment and polarization in obesity.

This study examines FAM19A5 expression and function in mice, finding low peripheral levels and no significant interaction with S1PR2.

This study investigates plasma adiponectin levels in metabolic syndrome patients and suggests drug repurposing for adiponectin regulation.

This study identifies redox signaling and IL-6 as key regulators of adipogenesis in adipose progenitor cells under obesogenic conditions.

This study shows that CD163 deficiency in obese male mice worsens insulin sensitivity by promoting inflammation and iron dysregulation in adipose tissue macrophages.

This study identifies sex-specific biomarkers and transcriptomic signatures in subcutaneous adipose tissue for obesity and T2D, highlighting sex differences in molecular mechanisms.

The paper introduces a novel 3D culture device for human omental adipocytes and macrophages derived from surgery to study post-surgical inflammation and morphological changes.

This study identifies the Nfe2l1-Atf3 pathway as a regulator of cholesterol-induced adipocyte inflammation and insulin resistance in both human and mouse models.

This study shows that inhibiting IRE1 improves insulin sensitivity, thermogenesis, and reduces metabolically active adipose tissue macrophages in obese mice.

This study shows that ABCC1 deficiency in male mice affects glucose metabolism and insulin tolerance on a high-fat diet without altering tissue corticosterone levels.

This study shows that HIF1α is essential for adipose tissue growth under normal conditions and in response to high-fat diets, by rechanneling metabolic intermediates into lipid synthesis.

This study shows that human sPRR expressed in adipose tissue improves insulin sensitivity and endothelial function in obese female mice, but not in males.

This study evaluates the sex-dependent impact of sarcospan deficiency on cardiometabolic traits in mice, finding age-related differences in adipose tissue and glucose handling, with more pronounced effects in females.

The paper constructs gene regulatory networks in visceral adipose tissue from obese and non-obese individuals, identifies altered network connectivity patterns, and validates novel gene candidates influencing adipocyte differentiation.

This study presents transcriptomic and proteomic analyses of obesity and T2D in cynomolgus monkeys, identifying tissue-specific molecular changes and potential therapeutic targets.

The paper identifies molecular and metabolic signatures of cardiometabolic syndrome using extreme phenotype groups and shows changes after bariatric surgery.

This study shows that deleting SLC7A8 in mice protects against diet-induced obesity by reducing lipid accumulation in multiple organs and improving glucose metabolism.

This study shows that reducing hypothalamic somatostatinergic neurons in mice leads to diabetes-like symptoms in multiple tissues without hyperglycemia.