Stress Responses and Cortisol

This study investigates how chronic stress affects neural processing of affective stimuli in the vmPFC of male and female rats, revealing sex-dependent and context-specific changes.

This study shows that blocking estrogen receptor beta in the central amygdala prevents stress-induced anxiety and depressive behaviors in female rats exposed to repeated social stress.

This study identifies dscaml1 as critical for CRH neuron development and stress axis function in zebrafish, showing its role in regulating cell number and stress hormone levels.

This study examines how footshock stress affects social behavior and neuronal activation in male and female mice, finding sex-dependent changes in defensive behaviors and cFos expression.

This study shows chronic stress impairs endogenous neurosteroid signaling in the BLA, leading to behavioral deficits, and suggests targeting neurosteroidogenesis could be a new treatment for mood disorders.

The paper identifies the thalamic paraventricular nucleus (PVT) as a region selectively activated by early-life adversity (ELA) in mice, linking it to long-term reward-related behavioral deficits.

The paper examines how loss of ultradian cortisol rhythm affects emotional processing in cortical brain regions by analyzing transcriptional and cell type profiles.

The paper identifies a glucocorticoid-sensitive period in zebrafish corticotroph development and links it to stress-related behaviors.

This study examines rapid volumetric brain changes after acute psychosocial stress using MRI and finds significant group-by-time interactions in grey matter volume and associations with stress measures.

This study investigates how early life stress and re-exposure to stress affect neuronal activity in the lateral habenula of adult mice, finding that hypoactivity and sensitized responses contribute to depressive-like behaviors.

This study identifies transthyretin (TTR) as a key regulator of escalated aggression and its intergenerational inheritance through impaired thyroid hormone availability in the brain.

This study shows that microglia in the locus coeruleus of female rats influence hypervigilant responses to social stress, with site-specific microglia depletion reducing stress-induced behaviors.

This study shows that maternal immune activation during lactation alters milk composition and leads to behavioral and physiological changes in offspring.

The paper demonstrates that hippocampal output to the BNST inhibits the HPA axis by disynaptic inhibition of CRF+ PVN neurons during acute stress.

This study shows that early life stress in zebrafish affects glucocorticoid signaling during a critical developmental window, leading to long-term anxiety-like behavior and cortisol dysregulation.

The paper shows that early-life adversity impairs microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons, leading to heightened stress responses later in life.

This study examines long-term effects of adolescent alcohol exposure on behavior and neurobiological markers in mice, finding persistent anxiety and changes in GR, CRF, and BDNF expression in limbic brain regions.

The paper characterizes behavioral, physiological, and neuroendocrine profiles of mice before, during, and after chronic social defeat stress, finding that early coping strategies better predict resilience or susceptibility than traditional behavioral read-outs.

This study reviews 39 rodent studies on early-life adversity's effects on immediate-early gene expression, finding that ELA increases cFos expression under specific conditions.

The paper identifies epigenetic changes in neocortical excitatory neurons under chronic stress that contribute to depression-like behaviors in mice.

This study links baseline interleukin-6 plasma levels to neural stress responses in healthy adults, finding negative associations in specific brain regions.

This study uses single-cell RNA sequencing to identify lasting transcriptional changes in hypothalamic CRH-expressing neurons after early-life adversity, linking these changes to long-term stress responses.

This study examines the effects of three water restriction schedules on rodent growth, hydration, and stress hormone levels over 80 days, finding no dehydration but differential stress responses.

The paper investigates transcriptomic changes in cortical microcircuit cell types under chronic stress and finds coordinated shifts in gene expression patterns associated with altered excitation-inhibition balance.

The paper shows that social rank and history of winning influence stress susceptibility in mice, with dominance conferring resilience and subordination increasing susceptibility.

This study shows that chronic adolescent stress increases exploratory behavior and hippocampal gene expression but does not affect acute stress responses in adult mice.

The paper investigates how self-related belief updating helps manage stress-induced negative affect after social-evaluative stress, showing it improves recovery compared to physical stress or no stress.

The paper investigates the cortisol awakening response (CAR) and its role in brain preparedness, finding that CAR predicts improved neural efficiency and working memory performance.

This paper investigates how chronic unpredictable stress affects CRF and glucocorticoid receptors in brain regions related to the HPA axis and finds that stress increases CRF2 and GR levels in specific brain areas.