Autophagy in Disease and Therapy

This study identifies a PINK1-dependent mitophagy pathway activated by hypoxia through HIF-1α/STOML2 axis, which protects neurons and suggests intermittent hypoxia as a therapeutic strategy.

The paper identifies an unconventional autophagic pathway that sequesters ATP to prevent its release during apoptosis, reducing immunogenicity.

This study identifies Sbp1 as a regulator of autophagy during genotoxic stress by modulating translation of autophagy genes and upstream activators.

This study shows that macroautophagy-induced lysosomal damage limits quiescent cell re-entry, and reducing this damage can enhance cell cycle re-entry in C. elegans and mammalian cells.

This study develops an image-based profiling approach to characterize autophagy-related phenotypes with high temporal resolution and identifies key morphological features for drug response prediction.

The paper shows that lysosomal uptake of mtDNA reduces heteroplasmy by enhancing mtDNA turnover through retromer-mediated mechanisms in Drosophila.

This study shows that senescent cells survive by enhancing lysosomal quality control and repair mechanisms, which can be targeted to induce cell death.

This study identifies RAB5c's role in regulating non-canonical autophagy machinery to enhance phagosome maturation and microbial killing by macrophages.

This paper identifies RAB1A and ARFGAP1-positive membranes as essential for autophagosome biogenesis, interacting with ATG2A to support lipid transport during autophagosome formation.

The paper investigates genetic factors involved in preventing paternal mitochondria transmission in C. elegans and finds that multiple pathways are required for complete degradation of sperm-derived mitochondria.

The paper describes endosomal-lysosomal organellar assembly structures in mouse oocytes and their dynamic changes during the oocyte-to-embryo transition.

The paper shows chronic lysosome damage from Palbociclib treatment in cancer cells triggers interferon responses via mitochondrial nucleic acid release, dependent on lysosome-mitochondrion contacts.

AURORA is a longitudinal single-cell framework that analyzes autophagy responses under nutrient stress, revealing cell-line-specific adaptations and shared remodeling programs.

The paper identifies ATG9 vesicles as a subtype of intracellular nanovesicles by analyzing their proteome and showing their role in autophagy.

This study shows that Stathmin 1 regulates mitophagy and mitochondrial health in hematopoietic stem cells by maintaining microtubule architecture and autophagy processes.

This study identifies RAS-induced non-canonical autophagy mediated by the P38-ULK1-PI4KB axis, showing its role in tumor growth and suggesting therapeutic targeting.

This study shows antigen and cytokines repress autophagy in CD8 T cells, shaping mitochondrial function, migration, and effector machinery through differential proteome pruning.

This study shows melatonin alleviates lysosomal damage in diabetic kidney disease by upregulating TFEB and the miR-205-5p-LRP-1 pathway, improving autophagy and oxidative stress.

The paper identifies a p53-proteasome-LC3 axis that suppresses autophagy in DNA damaged cells, linking p53 stabilization to reduced LC3A/B levels.

This study identifies overlapping SLiMs in NBR1 that mediate interactions with multiple autophagy receptors, revealing cooperative binding mechanisms and the regulatory role of phosphorylation.

This study identifies a vacuolar quality control pathway in plants that uses ATG8ylation to protect vacuolar integrity following cell wall damage.

This study quantifies the timeline of nuclear autophagy in yeast, revealing a role for Dnm1 in nuclear envelope remodeling during cargo removal.

This study shows that reducing Uchl5/UBH-4 impairs autophagy in human cells and varies by tissue in C. elegans.

This study identifies SNX10 as a negative regulator of piecemeal mitophagy and mitochondrial bioenergetics, showing its role in modulating mitochondrial homeostasis and cell survival.

This study identifies MOZT, a mitophagy process at the oocyte-to-zygote transition, which removes damaged mitochondria and preserves mitochondrial health, ensuring species continuity.

This study investigates how Atg18 binds to phosphatidylinositol-3,4,5-triphosphate, showing it clusters membranes and tethers opposing membranes.

This paper identifies REDD1 as a key determinant of renal cell carcinoma sensitivity to autophagy inhibition and shows that PIM kinase inhibition enhances this sensitivity through REDD1 upregulation.

This study shows endurance training improves lysosomal biogenesis factors in aged rat skeletal muscle, counteracting age-related sarcopenia and enhancing muscle function.