Bacterial biofilms and quorum sensing

This study shows that poly-N-acetylglucosamine (PNAG) enables Cutibacterium acnes biofilm formation and enhances resistance to antibiotics.

This study shows that low concentrations of degradative enzymes lack synergy in dispersing S. aureus biofilms, but a specific sequence of pepsin followed by zymolyase 20T shows synergy.

The paper shows that pyoverdine, a siderophore produced by Pseudomonas aeruginosa, protects bacterial communities from UV damage by acting as a public sunscreen.

The paper tracks bacterial cell lineage in growing colonies to reveal genealogical enclaves formed by activity-driven demixing.

This study identifies exosomes from Pseudomonas aeruginosa biofilms that either promote or inhibit biofilm growth depending on their developmental stage.

This study investigates how Chromobacterium subtsugae regulates antibiotic resistance genes through quorum sensing and a TetR-family repressor, showing independent modulation by CviR and CdeR.

DeepGEEP predicts bacterial biofilm gene expression profiles using synthetic data and a 2D-CNN model, achieving higher accuracy than traditional machine learning methods.

This study maps PNAG-binding proteins in S. epidermidis biofilms using proximity labeling and proteomics, identifying EbpS and its LysM domain as key interactors.

This study identifies YFJ toxin as a biofilm-specific intercellular signal in Bacillus subtilis that regulates cell fate through contact-dependent competition and controls DegSU activity.

The paper investigates how phenotypic plasticity in Bacillus subtilis biofilms enhances resilience through spatial organization and fluid transport properties.

This study compares two synthetic quorum sensing circuit architectures and evaluates three QS inhibition strategies to understand their steady-state behavior and parameter thresholds for effective suppression.

The paper identifies citrate cross-feeding between Pseudomonas aeruginosa genotypes as a mechanism that enhances fitness and virulence in lasR mutant strains.

The paper shows that citrate cross-feeding between Pseudomonas aeruginosa genotypes enhances fitness of lasR mutants in co-cultures by enabling citrate uptake and virulence factor expression.

This paper designs engineered variants of penicillin G acylase to selectively degrade bacterial signaling molecules, showing significant shifts in substrate specificity.

The paper models quorum sensing pathways with crosstalk and feedback, showing how crosstalk can enhance functional range and enable new activation modes.

The paper investigates a mechanism where resistant bacteria aid sensitive bacteria against antagonists, proposing a model that suggests this is feasible under specific metabolic conditions at high population densities.

This study investigates how Pseudomonas aeruginosa phospholipase A (PlaF) affects biofilm formation and virulence by altering membrane phospholipid composition and regulating multiple pathways.

The paper analyzes transcriptional patterns of core and accessory genes in P. aeruginosa strains using a transcriptome compendium, revealing stable core gene expression patterns across strains.

The paper develops an in vitro cell-free system to evaluate quorum sensing inhibitors by reconstituting Pseudomonas aeruginosa pathways in Escherichia coli.

RRNPP_detector identifies RRNPP quorum sensing systems in gram-positive bacteria genomes, revealing expanded diversity and novel regulatory mechanisms.

The paper models how additional regulatory modules in bacterial quorum sensing improve response speed and control.

This study investigates the FleS/FleR two-component system in Pseudomonas aeruginosa, showing it regulates virulence traits and biofilm formation through transcriptional control of multiple genes.

This study inhibits the accA gene in E. coli using antisense RNA, suppressing luxS expression and increasing antibiotic susceptibility.

The paper demonstrates that the quorum sensing peptide EntF* from gut microbiota promotes colorectal cancer metastasis in mice, identifying it as a novel mediator of microbiome-host interaction.

This study characterizes the quorum sensing system in Hafnia alvei FB1, showing its role in cell division, nutrient uptake, and antibiotic resistance through genomic and transcriptomic analyses.

This study investigates the association between biofilm formation and carbapenem resistance in Klebsiella pneumoniae isolates, finding a positive correlation and significant impact on patient outcomes.

The paper develops a mathematical framework to analyze paradoxical signaling in synthetic circuits for population control in E. coli, showing non-monotonic growth rate relationships and stability benefits.

The paper shows that Pseudomonas aeruginosa uses integrated diffusive cues to stabilize cooperative swarming behavior against cheating.

The paper shows quorum sensing in bacteria can detect environmental changes and uses a new signaling mechanism involving protein synthesis and dilution rates to process dynamic inputs.

The paper presents a cell-free method for sensing and quantifying the quorum sensing molecule 3OC12HSL in Pseudomonas infections using droplet microfluidics.