Food Allergy and Anaphylaxis Research

Ex vivo autologous immune cell assay to study modulation of type 2 Inflammation by processed- or novel food extracts in peanut allergy

This paper introduces an ex vivo assay to study how peanut extracts and novel foods modulate type 2 inflammation in peanut-allergic patients.

Sensitized infants who tolerate peanut have more dendritic cells and HLA-DR+ memory CD4 T cells

The paper identifies increased dendritic cells and HLA-DR+ memory CD4 T cells in sensitized infants who tolerate peanut, highlighting the importance of controlling staining batches in mass cytometry studies.

Rationally Engineered Self-Assembling Protein Nanoparticles for Allergen-Specific Peanut Allergy Immunotherapy

This paper develops self-assembling protein nanoparticles displaying peanut allergens to treat peanut allergy, showing robust protection in both prophylactic and therapeutic settings.

Longitudinal treatment selection under irreversible discontinuation: History-aware prediction and trajectory-aware learning in peanut-allergy prevention

This paper introduces TreatNet, a framework for longitudinal treatment selection under irreversible discontinuation, showing improved accuracy in peanut-allergy prevention decisions.

Ara h 2 and FcϵRIα binding elicit state-dependent allostery in IgE

This study investigates how Ara h 2 and FcϵRI binding affect IgE structural dynamics and allosteric communication, revealing conformational changes and shifts in communication pathways.

Repeated shrimp allergen exposure drives 5-lipoxygenase-dependent avoidance and selective gut-brain activation

This study shows that repeated shrimp allergen exposure leads to 5-lipoxygenase-dependent avoidance and specific gut-brain activation in mice.

Gut microbial composition modulates food-specific CD4+ T cells in food allergy

This study shows that gut microbial composition affects food allergen-specific CD4+ T cells, leading to differences in food allergy severity between mouse strains.

Eosinophil-epithelial interactions mediate protective intestinal remodeling during food allergy

This study shows eosinophils mediate protective intestinal remodeling in food allergies by interacting with epithelial cells, and their depletion worsens symptoms.

Circulating miR-29a as a new biomarker of food anaphylaxis and endothelial glycocalyx regulation

This study identifies reduced miR-29a-3p levels in serum and EVs during acute food-induced anaphylaxis and links it to endothelial glycocalyx regulation.

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis

This study shows that gut and oral bacteria metabolize peanut allergens, affecting IgE-binding and anaphylaxis severity in allergic individuals.

A Multi-Organ Single-Cell Atlas Maps Allergen and Organ-Specific Cellular Dynamics in the Progression from Food Allergy to Anaphylactic Shock

This paper constructs a multi-organ single-cell atlas to map cellular dynamics during food allergy progression to anaphylactic shock in mice, identifying organ-specific pathologies and conserved inflammatory pathways.

Dynamic Regulation of CD300b, and CD300f on Myeloid Cells in Oral Immunotherapy

This study examines changes in CD300b and CD300f expression on myeloid cells during oral immunotherapy and finds their dynamic regulation correlates with treatment response and immune tolerance.

Dual schema of allergens reveals molecular and evolutionary signatures

The paper identifies two allergen fold categories based on structural similarity to human proteins, revealing distinct molecular and evolutionary patterns and introduces a classifier for predicting allergens.

Multi-omics analysis reveals vitamin D metabolism, hyper-IgE genes, and epithelial barrier dysfunction in hazelnut allergy

This study identifies molecular differences in hazelnut allergy using multi-omics analysis, finding IL-5 as a key biomarker and linking the condition to vitamin D metabolism, hyper-IgE genes, and epithelial barrier dysfunction.

Proteomic characterization of major fish allergy responsive protein parvalbumins in Hilsa (Tenualosa ilisha): A commercially important fish in Southeast Asia

This study characterizes parvalbumin isoforms in Hilsa fish using proteomic methods, finding higher PRVB levels in young fish and lower PRVB compared to other freshwater fish.

Leveraging mRNA platform for the development of vaccines against egg allergy

This study develops mRNA vaccines against egg allergy using a mouse model and shows they prevent anaphylaxis by inducing allergen-blocking antibodies and shifting immune responses.

AllergenAI: a deep learning model predicting allergenicity based on protein sequence

AllergenAI predicts allergenicity using protein sequences, identifies a P-A motif in vicilins, and demonstrates potential for incorporating 3D structural data.

A mutation in Themis contributes to peanut-induced oral anaphylaxis in CC027 mice

This study identifies a Themis mutation as a genetic contributor to peanut-induced anaphylaxis in CC027 mice through genetic mapping and immunological analysis.

NetAllergen, a random forest model integrating MHC-II presentation propensity for improved allergenicity prediction

NetAllergen improves allergenicity prediction by integrating MHC-II presentation propensity, outperforming existing methods when sequence similarity to known allergens is low.

AllerStat: Finding Statistically Significant Allergen-Specific Patterns in Protein Sequences by Machine Learning

The paper introduces a machine learning method to identify statistically significant allergen-specific amino-acid sequences in proteins, achieving higher allergenicity prediction accuracy than existing approaches.

A Comparative Analysis of Novel Deep Learning and Ensemble Learning Models to Predict the Allergenicity of Food Proteins

This paper compares deep learning and ensemble learning models for predicting food protein allergenicity, finding that the transformer model achieved the highest AUC of 0.9578.

Novel allergen discovery through comprehensive de novo transcriptomic analyses of 5 shrimp species

The paper identifies known and novel allergens in five shrimp species through transcriptomic analysis, revealing potential targets for improved diagnostics and immunotherapeutics.