Robert J. Pignolo

This study shows that early suppression of the pro-inflammatory senescent secretome (SASP) with ruxolitinib reduces chronic bone damage after radiotherapy.

The paper identifies common differentially regulated microRNAs in skeletal aging and radiation-induced bone deterioration, linking them to WNT pathway modulation and senescence.

This study presents a longitudinal assessment of age-related changes in Brown-Norway rat physiology and histopathology at 6, 17, and 27 months of age to provide healthspan parameters for aging research.

This study identifies p21+ senescent-like cells, including osteochondroprogenitors and neutrophils, as key regulators of fracture repair, showing their distinct roles from age-related p16+ senescent cells.

This study shows that cellular senescence drives bone marrow adiposity in radiation- and aging-associated bone loss through miR-27a upregulation and senolytic treatment reduces BMAT.