Genetics, Aging, and Longevity in Model Organisms

The paper identifies shared plasma metabolomic biomarkers of mortality in dogs and humans, showing strong correlations between metabolite effects on all-cause mortality in both species.

This study identifies shared genetic pathways and genes under positive selection in long-lived mammals and birds, suggesting convergent evolution of longevity mechanisms.

The paper identifies topoisomerase I (Top1) depletion in aging yeast cells and shows its impact on rDNA silencing and replicative lifespan.

This study shows that protein aggregation in E. coli drives aging by reducing intracellular space, leading to larger cell sizes and asymmetric divisions.

The paper uses machine learning to identify plasma metabolomic and proteomic features that distinguish slow-aging mice from controls, finding triglycerides with varying fatty acid chain lengths as key predictors.

The paper examines sex- and age-related differences in cellular aging markers in painted turtles, finding sex is a stronger predictor of aging physiology than age or size.

This paper identifies Cyrene as a geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila, improving stress resistance and neuroprotection.

This study shows that warmer temperatures accelerate senescence in mosquitoes by altering transcriptome changes related to immunity, metabolism, and DNA repair.

The paper investigates how different dietary macronutrient conditions affect insulin-like peptide expression and developmental outcomes in Drosophila.

The paper develops a stochastic model to evaluate how DNA replication asymmetry affects proteostasis collapse dynamics under age-related clearance decline, finding that asymmetry modestly increases load and accelerates collapse under stress.

This study investigates how sleep at different life stages affects longevity in Drosophila, finding that early life sleep is positively associated with longer lifespan.

The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.

This study identifies tRNA-mediated proteostasis as a mechanism by which SWR1C loss extends longevity in yeast.

The paper develops a linear regression model to predict biological brain ageing and identifies age-related gene expression patterns linked to Parkinson's disease susceptibility.

This study examines RNA synthesis and degradation rates in naked mole-rat and mouse fibroblasts, finding higher degradation rates in aging-related pathways in NMRs.

This study identifies LMD-3 as a regulator of proteostasis and reproductive capacity in C. elegans, showing its role in lysosomal function and the reversibility of fecundity decline with vitamin B12.

This study maps metabolic changes in 12 organs of male and female mice across 5 ages, identifying sex-specific patterns and a metabolic aging clock.

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

This study shows that activating ADH-1 extends healthspan in multiple species by improving proteostasis and reducing age-related diseases.

This study identifies KLF-1 as an upstream regulator of SKN-1/Nrf transcription factors in C. elegans, linking lipid homeostasis, oxidative stress, and longevity.

The paper develops a platform for continuous behavioral tracking of vertebrates across their lifespan and identifies distinct aging trajectories linked to transcriptomic changes and predictive models of lifespan.

The paper identifies INS-17 as a specific insulin-receptor ligand in C. elegans that regulates learning and memory independently of lifespan.

This study identifies a gut microbiota-muscle axis in C. elegans that protects against age-related motor decline by regulating mitochondrial fission through DRP-1.

The paper introduces a tool to estimate age-specific treatment effects on mortality hazards, applied to mouse data showing varying efficacy of life-extending interventions across lifespan stages.

This study presents a single-cell epigenomic and transcriptomic atlas of aged mice under germ-free conditions, revealing sterile inflammation as an intrinsic ageing feature.

The paper identifies E. coli mutants that extend C. elegans lifespan via oxidative stress and iron homeostasis pathways.

This study examines how stress and aging affect spore health in Schizosaccharomyces pombe, identifying declines in germination, asymmetry, and stress tolerance.

This study shows that disrupting the insulin signaling pathway in male C. elegans significantly increases lifespan and improves reproductive health late in life.

This study uses RNA-sequencing to analyze transcriptomic changes in C. elegans under different mitochondrial stressors that activate UPRmt, aiming to determine if specific transcriptomic changes correlate with longevity.

This study shows aging suppresses lung tumor initiation and growth in mice, with age-dependent effects on tumor suppressor genes like PTEN and persistent age-related transcriptomic changes in tumors.