Genetics, Aging, and Longevity in Model Organisms

This study shows that tissue-specific overexpression of SID-1 in C. elegans reduces lifespan, implicating systemic RNA transport in lifespan regulation.

This study identifies 3-phenyllactic acid (PLA) as a metabolite from lactic acid bacteria that extends healthspan in C. elegans by enhancing mitochondrial function and stress resilience, and links PLA levels to sarcopenia in humans.

This study identifies SRSF1 as a rejuvenation factor through transcriptomic reprogramming, showing it improves cellular function and is linked to longevity.

This study shows that floxuridine enhances proteasome function in C. elegans, improves cold survival, and activates a detoxification pathway independent of SKN-1 and the germline.

The paper constructs a synthetic yeast chromosome and identifies aging regulators through replicative lifespan studies and genome-scale analysis.

This study reanalyzes proteostasis in C. elegans and finds that polyubiquitinated protein levels remain constant with age, contradicting a previous conclusion.

The paper investigates how cell-specific turnover rates influence transcriptome aging across organs and develops a model to explain differential aging rates.

This study shows that enhancing skeletal muscle TFEB signaling reduces neuroinflammation and tau pathology in aging and neurodegenerative disease models.

The paper analyzes the multiome of Diversity Outbred mice to explore how aging and lifespan are related, finding that proteomic changes correlate with biological age rather than chronological age.

This study shows that age-related loss of intestinal amino acid transport in Drosophila reduces lifespan and is linked to increased amino acid load in faecal matter driven by the microbiota.

This study shows that young porcine plasma treatment reduces epigenetic age in multiple rat organs and improves physiological function.

This study identifies E. coli-derived vitamin B6 (PLP) as essential for resuming postembryonic development in C. elegans after developmental arrest.

This paper provides a transcriptional dataset of aging tissues from African turquoise killifish, showing age has a greater impact than sex on gene expression and TE transcription.

The paper introduces a two-phase model of ageing using Smurfness to distinguish chronological age effects from biological age effects in transcriptional data.

The paper updates six databases in the Human Ageing Genomic Resources (HAGR) focusing on genes, drugs, and genetic variants related to ageing and longevity.

This study shows that mutating lysine-36 of Drosophila histone H3.3 reduces adult lifespan and disrupts genomic and transcriptomic stability.

This study shows phenformin extends lifespan in C. elegans more consistently than metformin, which is affected by environmental factors like agar batch.

This study identifies MG-H1 as a mediator of increased food intake in C. elegans glod-4 mutants through a tyramine signaling pathway regulated by the GATA transcription factor ELT-3.

The paper identifies E. coli purE mutants that delay C. elegans development and increase stress tolerance via DAF-16 nuclear translocation.

This study compares four rejuvenation strategies in mice and identifies a shared gene expression program involving reduced inflammation and restored fatty acid metabolism, suggesting inflammation as a key upstream factor in aging.

This study shows curcumin extends the lifespan of aging postmitotic yeast cells with mitochondrial dysfunction, but not under conditions of mitochondrial dysfunction.

Activating the Gαq pathway in aged worms and mice improves memory and cognitive function, demonstrating conservation across species.

The paper shows that an early-life galactose diet in yeast reduces age-related gene dysregulation and senescence markers, suggesting dietary change can mimic caloric restriction benefits without calorie reduction.

This study integrates multi-omics data from female nonhuman primates to identify aging-related molecular changes in the liver, revealing age-associated pathways in endoplasmic stress and degradation.

This study identifies hemin as an anti-aging agent that extends cellular lifespan through the AMPK pathway and synergizes with rapamycin in human and yeast models.

This study shows that arginine-rich peptides cause nucleolar stress, leading to ribosomopathy and accelerated ageing in mice, with mTOR inhibition alleviating lifespan reduction.

This paper creates a single-cell atlas of aging in C. elegans, revealing cell-type specific aging patterns and identifying transcription factors that regulate aging rates.

This paper connects metabolic slowdown to ageing and age-related diseases through a fuel and energy model, explaining anti-ageing interventions and paradoxes of ageing.

This study identifies MANF as a regulator of autophagy and lysosome function, improving proteostasis and extending lifespan in C. elegans.