Genetics, Aging, and Longevity in Model Organisms

This study integrates multi-omics data from female nonhuman primates to identify aging-related molecular changes in the liver, revealing age-associated pathways in endoplasmic stress and degradation.

This study identifies hemin as an anti-aging agent that extends cellular lifespan through the AMPK pathway and synergizes with rapamycin in human and yeast models.

This study shows that arginine-rich peptides cause nucleolar stress, leading to ribosomopathy and accelerated ageing in mice, with mTOR inhibition alleviating lifespan reduction.

This paper creates a single-cell atlas of aging in C. elegans, revealing cell-type specific aging patterns and identifying transcription factors that regulate aging rates.

This paper connects metabolic slowdown to ageing and age-related diseases through a fuel and energy model, explaining anti-ageing interventions and paradoxes of ageing.

This study identifies MANF as a regulator of autophagy and lysosome function, improving proteostasis and extending lifespan in C. elegans.

The paper shows that aging in killifish brains reduces basic amino acid-rich proteins through translation pausing, not transcription or proteasome issues, revealing a vulnerability in nucleic-acid protein biogenesis.

This study shows glial cells in C. elegans sense mitochondrial stress and signal to neurons to improve protein homeostasis and longevity.

The paper aligns ages across 8 primate species using behavior, anatomy, and transcription data, revealing human-specific biological pathway extensions and the uniqueness of very old age in humans.

This study identifies ether lipid biosynthesis as a key pathway mediating the longevity benefits of biguanides like metformin in C. elegans.

This study shows that inhibiting IL11 improves healthspan in aged mice by reversing metabolic dysfunction, sarcopenia, and frailty.

This study introduces highly regenerative species-specific genes into Drosophila to improve stem cell function and extend lifespan by enhancing gut barrier functions during aging.

The paper analyzes proteomic changes across 10 tissues in mice at different ages, finding age-related increases in immune proteins and tissue-specific alterations in protein complexes.

This paper shows that overexpression of FOLR-1 in C. elegans shortens lifespan, dependent on gut microbiota, revealing a non-canonical role of folate receptors in aging.

This study shows that developmental mitochondrial dysfunction limits lifespan in Drosophila, while adult dysfunction accelerates ageing, with metabolic adaptations during development being critical for survival.

This study uses network analysis in Drosophila melanogaster to identify mitochondrial genes associated with aging and age-related diseases.

The paper explains Gompertzian mortality patterns using a systems model that incorporates inter-dependent subsystems and their temporal failure, providing insights into biological aging and heterogeneity.

This study identifies HPK-1 as a neuronal transcriptional regulator that maintains proteostasis and extends longevity in C. elegans by modulating serotonergic and GABAergic pathways.

The paper shows that GABA inhibits and acetylcholine promotes the mitochondrial stress response in C. elegans intestine via a neuro-intestinal circuit.

This study shows that mutating APRT in turquoise killifish extends male lifespan and improves metabolic health, with mitochondrial function and AMPK activity playing key roles.

This study shows that adapting Drosophila to a high-sugar diet increases lifespan and reveals cholinergic signaling's role in longevity under overnutrition.

The paper identifies two rare variants in the MAPK/ERK pathway from long-lived families and shows they affect signaling and metabolism differently in mouse embryonic stem cells.

voyAGEr provides a web tool to analyze age-related gene expression changes in 49 human tissues using GTEx RNA-seq data, enabling visualization and statistical exploration of sex- and tissue-specific transcriptomic alterations.

This study identifies daf-42 as an essential gene for dauer development in C. elegans, showing it is evolutionarily young and critical for survival under adverse conditions.

This study identifies miR-142-3p as a regulator of human longevity by modulating the insulin/IGF-1 signaling pathway in B-cells and mice.

The paper shows that miR-238, not its sequence-similar miR-239ab siblings, promotes longevity in C. elegans through expression levels, not sequence differences.

The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.

This study shows that disrupting TBC-2 reduces lifespan and stress resistance in long-lived mitochondrial mutants in C. elegans, suggesting a role for endosomal trafficking in mitochondrial dysfunction-related longevity.

This study shows that a specific diet, Lactobacillus reuteri, can preserve associative learning in aged C. elegans through DAF-16 pathway activation without affecting lifespan.