Genetics, Aging, and Longevity in Model Organisms

The paper identifies compounds that mimic calorie restriction by inducing liver gene signatures similar to those observed under calorie restriction in mice and rats.

This study shows that polyploid cells accumulate in the ageing Drosophila brain and are more resistant to DNA damage-induced cell death than diploid cells.

This study identifies age-vulnerable motor circuit functions in Drosophila under oxidative and temperature stress, showing distinct aging patterns and highlighting potential neurophysiological markers.

The paper uses single-cell RNA-sequencing to show that caste transition in ants leads to glia remodeling associated with extended lifespan.

The paper identifies SOD-2 as the only active SOD enzyme in C. elegans through in-gel activity analysis and mutant studies.

RNAAgeCalc calculates transcriptional age across tissues using age-related genes identified from GTEx and validates its predictive power using TCGA data.

This study identifies nhx-2 as a modulator that extends reproductive longevity and ameliorates alpha-synuclein aggregation effects in C. elegans by mimicking dietary restriction.

The paper identifies SEM-4 as a transcription factor required for regulating oxidative stress response by activating skn-1c and phase II detoxification genes in C. elegans.

The paper shows that ADAM17-triggered TNF signaling in Drosophila retina protects against age-related lipid droplet-mediated degeneration by initially buffering ROS but later causing toxic lipid release.

The paper uses multidimensional phenotyping of C. elegans to predict lifespan and quantify health, showing that more features improve prediction accuracy.

This study shows that caloric restriction in Daphnia magna causes extensive gene expression changes, including a shift in haemoglobin isoform preference, similar to hypoxia responses.

The paper shows that interactions between chromatin silencing and mitochondrial pathways create an epigenetic landscape that determines cell fate during aging, and introduces a genetically engineered long-lived state.

This study identifies age-dependent changes in rDNA copy number, methylation, and sequence variations in mice, linking these alterations to reduced pre-rRNA levels and shortened yeast lifespan.

The paper compiles healthspan-related gene pathways in C. elegans and humans using literature review and molecular interaction data, identifying common themes like transcription and lipids.

The paper identifies an amino acid substitution in the Drosophila insulin receptor that extends lifespan without affecting growth or reproduction.

This study identifies genes contributing to beaver longevity and cancer resistance through genomic analysis of gene copy number, expression, and evolutionary changes.

This study examines age-related changes in the transcriptome and translatome of mouse tissues, revealing U-shaped gene expression patterns and age-related declines in protein synthesis.

This study examines the effects of phenolic acids on aging and metabolism in C. elegans, finding they improve lifespan and stress resistance but do not enhance mitochondrial function.

The paper identifies rare genetic variants associated with exceptional longevity through pedigree analysis and genomic screening in Utah populations.

This paper shows that CREB regulates reproductive aging in C. elegans by controlling a Hedgehog-related signaling factor, WRT-10, through the TGF-β Sma/Mab pathway in the hypodermis.

The paper identifies genetic mechanisms underlying diet-dependent lifespan and healthspan in D. melanogaster using GWAS and validates gene effects on lifespan and climbing ability.

This study shows that reduced proteasome activity in aging brains leads to ribosome stoichiometry loss and aggregation, increasing mortality risk in killifish.

The paper introduces an optimized competitive-aging method to identify gene-drug interactions affecting yeast chronological lifespan, revealing a link between protein glycosylation and metformin-induced lifespan extension.

This study shows that mutations in egl-9 and rhy-1 suppress the long-lived phenotype of vhl-1 mutants in C. elegans, indicating a VHL-1-independent role for EGL-9 and RHY-1 in longevity regulation.

This study identifies a conserved metallophosphodiesterase in Drosophila that influences lifespan, with neuronal expression capable of rescuing lifespan defects.

The paper investigates amino acid variations in p53 across species and finds correlations between specific substitutions and extended lifespan.

The paper identifies a neuronal circuit in C. elegans that modulates hydrogen peroxide defenses based on sensory input and bacterial presence.

The paper identifies intragenic repeat expansions in yeast that influence chronological aging by altering cellular metabolism and environmental interaction.

This paper models the aging self-organization system using supervised learning to optimize aging networks and study molecular mechanisms of aging and related diseases.

The paper analyzes longevity interventions across species and identifies a structured 'landscape of longevity' with soft bounds on achievable lifespan, including a human upper limit of ~138 years.