Genetics, Aging, and Longevity in Model Organisms

The paper introduces Longevity-LLM, a foundation model fine-tuned on aging-related data, achieving high performance in age prediction and proteomic profile generation across multiple modalities.

This study shows that reducing Indy gene activity in Drosophila lowers bacterial load and preserves gut homeostasis, extending lifespan through JAK/STAT signaling pathway modulation.

This study shows that age-dependent H3K9 trimethylation by dSetdb1 impairs UPRMT in Drosophila olfactory neurons, leading to neurodegeneration and loss of olfactory function, which can be reversed by dSetdb1 knockdown.

This study identifies FMO-2 as a downstream effector of multiple longevity pathways in C. elegans mitochondrial mutants, showing its requirement for lifespan extension.

The paper combines supervised and unsupervised machine learning to improve aging predictions in mice by identifying latent frailty signatures.

This study shows that refeeding reverses aging-like phenotypes in C. elegans reproductive diapause by selectively activating the IRE-1 branch of UPRER and enhancing protein synthesis and folding.

The paper introduces the Cepeda Framework, a computational preclinical model testing coordinated rejuvenation strategies across 12 aging hallmarks using safety-gated simulations.

This paper challenges classic evolutionary theories of aging by showing that rejuvenation's avoidance in nature contradicts these theories, suggesting an alternative adaptive framework.

The paper develops an in vitro platform to screen immune senomodulators using human-derived immune cells, enabling personalized anti-aging treatments through multi-scale molecular analysis.

This study tests the redox theory of aging by evolving mosquitoes under different reproductive schedules and parasite exposure, finding that oxidative stress contributes but does not determine aging.

This study shows SIN3 regulates glycolytic gene expression and lifespan in Drosophila under metabolic stress, acting as a metabolic sensor and linking transcription to organismal adaptation.

The paper shows that GCY-9 in C. elegans carbon dioxide sensing neurons primes mitochondrial stress response to enhance metabolic resilience under starvation.

The paper creates a multi-tissue transcriptomic aging atlas in killifish, identifies age-altered pathways, and develops tissue-specific transcriptomic clocks with sex-specific biomarkers for aging prediction.

The paper shows that in C. elegans, lifespan is limited by competing senescent pathologies, and removing one can unmask another, indicating lifespan extension may not reflect reduced aging rate.

The paper develops a flexible diet platform for nutrigenomic screening in Drosophila disease models, showing it can identify nutrient-specific effects on disease phenotypes.

This study shows that mid-infrared light at 34 THz extends the lifespan of C. elegans by 60% through enhancing cellular efficiency, not by thermal effects or stress response activation.

The paper uses yeast aging to map proteome changes across age, revealing structural determinants of age-sensitive remodeling and providing a resource for aging research.

The paper uses single-cell spatial proteomics in yeast to uncover molecular changes linked to aging hallmarks and their spatial organization.

This study shows that selecting Drosophila for postponed reproduction increases lifespan and immune defense, with convergent genetic changes across populations.

This paper presents a short-term performance assay in mice to evaluate functional benefits and early toxicity of anti-aging interventions, identifying compound-specific effects and highlighting potential toxicity.

This study shows that restoring ribosomal homeostasis by targeting RNAse P/MRP or mitochondrial ribosome extends lifespan in C. elegans by improving proteostasis and ribosome assembly.

This study identifies age and survival-related transcriptomic signatures in longevity-enriched cohorts using RNAseq data from blood samples.

This study identifies new regulators of heat hormesis in C. elegans through transcriptomic and chromatin accessibility analysis, revealing tissue-specific responses and conserved factors involved in stress resilience and longevity.

The paper describes a reversible form of suspended animation in C. elegans induced by high population density and identifies molecular mechanisms regulating its induction and termination.

This study evaluates the longitudinal behavior of organ-specific proteomic aging clocks over a decade, finding stability in age acceleration and links to subclinical risk factors and menopause in women.

This study identifies retrotransposon dynamics and chromatin regulation as key mechanisms by which metformin extends lifespan in yeast.

This study shows that genetic background and sex influence responses to intermittent fasting in mice, with effects on lifespan and health outcomes varying across strains.

The paper tests pro-longevity compounds on C. elegans males, finding lifespan extension in all tested conditions but only two compounds improved reproductive healthspan.

This study identifies DAF-2 as a key modulator of risky foraging behavior in C. elegans under food deprivation and shows multiple downstream pathways, including DAF-16 and CASY-1, are involved.