Forensic and Genetic Research

TranslucentID identifies contributors in saturated DNA SNP mixtures by desaturating them using minor allele ratios, improving detection confidence in forensic analysis.

This paper compares SNP selection and concordance across three DTC genetic testing platforms, finding low SNP overlap and platform-specific strategies for ancestry determination.

This study investigates the ability to re-identify individuals through long-range familial searches in consumer genomics databases, finding that half of European-descent searches could yield close matches enabling re-identification.

The paper investigates mito-nuclear incompatibility in admixed populations, finding that mtDNA copy number decreases with increasing discordance between nuclear and mitochondrial ancestry.

The paper shows linkage disequilibrium can identify relatives using nonoverlapping genetic markers, with 30-36% accuracy for parent-offspring and sib pairs.

This study analyzes genome-wide data from inner Eurasian populations to characterize genetic admixture patterns and their historical context.

The paper analyzes genome-wide SNP data to assess Sephardic ancestry in Iberian Peninsula populations and surrounding regions, finding evidence of recent Sephardic admixture and challenges in ancestry assignment.

The paper creates a reference dataset of 11 million SNP profiles for DNA forensics applications across diverse ethnicities, kinship, and admixture.

The paper analyzes genetic variation in Central Eurasia to infer population history and pigmentation patterns, finding convergent evolution in skin pigmentation genes.

This study provides direct and indirect evidence of frequent mtDNA recombination in humans, challenging the non-recombination dogma and its implications for evolutionary history and disease.

This paper introduces a method combining genetic bootstrapping, multidimensional scaling, and discriminant analysis to classify genetic relationships with high accuracy using identity-by-state data.

The paper presents a method to estimate population divergence times from SNP data and tests for treeness in population history using archaic genomes.

The paper estimates the age of rare alleles using haplotype sharing to infer demographic history and selection pressures in a UK population.

MITOMIX uses a new distance metric to analyze admixture in populations, showing modern Hungarians have mostly European ancestry with minor contributions from conquerors.

The paper introduces the Plateau method to deconvolve DNA mixtures into individual sub-profiles using SNP data without reference profiles, detecting contributors as low as 1/200 in concentration.

The paper addresses criticisms of a previous study on identifying individuals from whole-genome sequencing data by demonstrating the limitations of Erlich's simulation and highlighting the algorithm's use of multiple trait-based predictive models.

The paper analyzes ancient and present-day genome-wide data to show widespread Paleo-Eskimo ancestry among Na-Dene and Eskimo-Aleut language speakers and presents a model for North America's peopling.

The paper analyzes 289 genome sequences from Nilo-Saharan and Niger-Congo populations to identify population-specific selection signatures linked to disease resistance.

The paper links Neolithic Y haplotypes to autism spectrum disorder (ASD) by showing higher frequencies of low SES haplotypes in ASD fathers and a male-biased ASD ratio in related surnames.

The paper estimates recent African gene flow into the UK population, identifying old rare variants that suggest a 1.2% contribution approximately 400 years ago.

The paper critiques Lippert et al.'s method for re-identifying individuals from whole-genome sequencing data, highlighting its flaws in performance, methodology, and conclusions.

The paper examines cultural similarities among the Yakut population by analyzing genetic and archaeological data from ancient and modern samples, linking them to clan structures and marriage patterns.

The paper analyzes the spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes, finding increased frequencies of certain haplogroups linked to immigration.

The paper reports European admixture in a 4000-year-old Chinchorro mummy, challenging the traditional view of pre-Columbian isolation.

ATLAS, a C++ toolkit that models post-mortem damage when genotyping ancient or low-depth BAM data, avoided GATK's reference bias and made fewer errors at higher depth in simulations.

This paper presents ancient DNA data from Northern Europe to reconstruct the genetic history of the region, showing earlier Anatolian farmer ancestry and the impact of steppe pastoralists.

This study uses DNA SatNav to trace the biogeographical origin of South Asian populations, finding ancient admixture between North and South Indian populations around 2300 years ago.

yHaplo walks the Y-chromosome tree with an error-tolerant breadth-first search, labelling the 1,244 1000 Genomes males in 20 seconds and matching every gold-standard call.