Forensic and Genetic Research

The paper proposes a deep learning model for dimensionality reduction of genotype data, showing improved population clustering and visualization compared to PCA, t-SNE, and UMAP.

This paper develops an automated workflow to place ancient DNA sequences into reference phylogenies, using a parsimony and likelihood-based approach, and applies it to Y-chromosomal data.

The paper compares probabilistic genotyping of single-cell subsamples with standard bulk mixture analysis, finding that single-cell methods recover higher likelihood ratios for donors in complex DNA mixtures.

This study analyzes whole-genome data from ancient populations to trace the genetic origins of Huns, Avars, and conquering Hungarians, identifying their immigrant cores and genetic links.

This paper presents a non-destructive method to extract DNA from preserved tissues and their fixative solutions, enabling genetic analysis without damaging the samples.

The paper analyzes genetic continuity of Indo-Iranian speakers in Central Asia by comparing modern populations with ancient genomes, finding strong continuity since the Iron Age with limited gene flow.

The paper analyzes ancient DNA from Iron Age Apulian sites to explore the genetic origins of the Daunians and their place in the Pan-Mediterranean genetic landscape.

The paper uses genome-wide array genotyping to infer northern gene flow into southeastern East Asians by analyzing present-day and ancient populations.

This study analyzes genome-wide SNPs from Hmong-Mien speakers to reveal genetic substructure, a new ancestral lineage, and adaptive signatures linked to nervous system functions.

This study evaluates imputation methods for ancient DNA data using Beagle 4.0 and 1000 Genomes reference data, showing high accuracy at low coverage and benefits of phased references and low-coverage samples.

The paper analyzes genome-wide data from 66 ancient individuals from Kulubnarti to explore genetic ancestry and social stratification in Christian Period Nubia, finding no genetic differentiation between socially stratified cemeteries.

The paper analyzes genetic diversity patterns across human ethnic groups using the 1000 Genomes Project data, identifying group-specific fixed alleles and their evolutionary implications.

This study examines the population structure and demographic history of British Pakistanis, revealing strong recent structure and low effective population sizes due to endogamy and consanguinity.

The FORCE panel is a 5,422 SNP set for forensic applications, showing strong performance in kinship analysis and SNP recovery from degraded samples.

This study uses multi-omics analysis of ancient human remains from Sicily to show genetic homogeneity and a diet rich in animal proteins during the Upper Palaeolithic.

This study analyzes genetic markers in Amami islanders to determine their genetic relationship to mainland Japan and Okinawa, finding intermediate mtDNA and Y-STR profiles but distinct autosomal SNP frequencies.

This study quantifies secondary DNA transfer on denim using a human blood analogue and shows that friction leads to the highest DNA transfer and STR profile quality.

This study uses genomic data to analyze the recent population history of the Mapuche, finding shared ancestry with Southern Patagonia and Central Chile populations, a population bottleneck around 1650 AD, and post-admixture adaptation in Chileans.

This study uses SNP capture panels to analyze degraded historical DNA samples and estimate kinship up to 4th degree relatives with varying success based on panel size.

This paper presents STRspy, a method for accurate STR profiling using nanopore sequencing, achieving 100% concordance with validated genotypes and identifying flanking SNPs with >90% accuracy.

This paper analyzes genomic data from Sherpa people to explore their genetic origin, evolutionary history, and forensic characteristics using InDels and SNPs.

The paper infers the demographic history of the Nama population and constructs a population-specific recombination map, showing it diverges from existing continental recombination maps.

This paper introduces a method using Levenshtein distance to assess accuracy and precision in forensic PCR-MPS methods by comparing read sequences to reference sequences and measuring agreement among reads.

This study evaluates how compromised DNA affects kinship classification success using SNP microarray data in investigative genetic genealogy.

This paper introduces TKGWV2, a pipeline for estimating genetic relatedness in ancient DNA with ultra-low coverage data, showing it can detect first-degree relationships at 0.012x coverage.

The paper examines genetic diversity at HLA loci in the MHC region, showing that while SNPs show low FST values, haplotype frequencies vary geographically, impacting bone-marrow transplantation.

The paper uses ancient DNA and machine learning to study gene regulation changes in human populations and their link to environmental adaptation.

The paper introduces a method to improve DNA quantity estimation using RFU values and Bayesian Networks, enhancing accuracy for degraded samples and enabling standardized quantification across labs.

The paper analyzes genome-wide SNP data from Sanya Hui people to infer their genetic origins and admixture history, revealing tripartite origins from Central Vietnam, East Asia, and Central/South Asia.

The paper uses genomic data to infer admixture dynamics in colonial Mexico, identifying the genetic legacy of the Manila Galleon trade route from Southeast Asia to Acapulco.