Wound Healing and Treatments

This study shows that GPR132b in zebrafish affects wound healing and infection resistance by modulating macrophage activity and lipid signaling pathways.

This study develops a 3D multicellular in vitro model to assess ADSC-EVs' impact on vascularisation and wound healing, finding enhanced vessel formation and macrophage co-localisation with EV treatment.

This paper develops a deep reinforcement learning framework for real-time wound healing treatment optimization, showing 17.71% acceleration in in silico experiments and 40% in vivo.

The paper investigates how genetic regulation of tissue expression influences chronic wound microbiome composition through a microbiome-transcriptome-wide association study.

This study compares ECM proteomic changes during ear punch regeneration in Acomys cahirinus and Mus musculus, identifying differences in ECM proteins, crosslinking enzymes, and CD206 expression.

This study shows that xylazine and fentanyl co-administration in mice delays wound healing, while neither drug alone does so at tested doses.

This study shows that γδ T cells interact with NPY1R+ neurons in skin during wound repair, and obesity impairs these interactions, suggesting a neuroimmune disruption in wound healing.

This study shows that topical 4-aminopyridine delivered via a gel formulation accelerates burn wound healing by enhancing re-epithelialization, hair follicle regeneration, and fibroblast to myofibroblast transformation.

This paper develops a human microphysiological system to study neutrophil reverse migration mediated by macrophage-derived extracellular vesicles in sterile injury.

This paper develops a remote-controlled wireless bioelectronic system for delivering fluoxetine to promote wound healing in pigs, showing improved re-epithelialization and reduced inflammation.

The paper develops a collagen-GAG scaffold with ultrasound-triggered sequential release of AAV vectors to promote chronic wound healing.

This study shows that TGF-β from M2 macrophages inhibits TSG-6 expression in mesenchymal stem cells, promoting wound healing by reducing anti-fibrotic effects.

This study identifies reparative fibroblasts in aged mice that enhance scarless wound healing through EREG signaling, showing their role in regenerative outcomes.

The paper develops a multi-scale computational model of wound healing that simulates senescent cell dynamics and SASP profiles to understand their role in tissue repair and disease states.

This study evaluates the wound healing efficacy of aqueous extracts of three medicinal plants and their combination in mice, showing faster closure and improved tissue remodeling.

This study shows ROS inhibit myosin phosphorylation to counteract wound contraction, delay closure, and impair regrowth, while chronic ROS depletion alters tissue stiffness and impairs healing.

This study shows that reconstituted high-density lipoproteins (rHDL) restore impaired PDK4/PDC axis activity and angiogenic responses in diabetic endothelial cells under hypoxia.

The paper develops a mathematical model of wound healing dynamics to show that deregulated apoptosis and low TIMP production lead to chronic wounds, and that TIMP-containing hydrogels can reverse them.

This study shows that keratinocyte arginase1 deficiency impairs wound healing and antimicrobial defense against Pseudomonas aeruginosa by reducing epithelial proliferation and anti-microbial peptide production.

This paper uses spatial transcriptomics and hypergraph analysis to identify distinct transcriptomic signatures in acute versus chronic wounds, revealing pathway differences and entropy patterns.

This study shows that platelet granule cargo packaging and endocytosis are essential for proper skin wound healing in mice, affecting multiple phases of the healing process.

This study shows that melanization limits polyploid cell growth during wound healing in Drosophila, ensuring efficient wound closure.

This study shows that oral tolerance to ovalbumin reduces inflammation and improves healing in multiple wounds across different body parts in mice.

This study evaluates the safety and effectiveness of Purasomes IRC100+, a bovine colostrum secretome product, on vaginal epithelial and fibroblast cells in vitro, showing improved cell viability and migration.

The paper presents a wearable imaging system for automated wound monitoring in pigs, validated to capture and analyze wound progression using machine learning.

The paper shows isotonic medium treatment reduces epithelial damage spread and microbial colonization in burn wounds in larval zebrafish and human skin.

The paper investigates how KDM6A deregulation contributes to delayed wound healing caused by Candida albicans infection, highlighting its role in modulating metalloproteinase expression.

This study identifies pro-regenerative features in TSP2-deficient fibroblasts through single-cell analysis and functional assays, showing enhanced migration, proliferation, and neurogenesis.

This study identifies how tissue mechanics and hyaluronic acid regulate digit tip regeneration by modulating ECM composition and cell behavior.

The paper identifies deep skin fibroblasts as a source of pro-inflammatory factors that drive macrophage recruitment and support wound healing in mice.