Research on Leishmaniasis Studies

This study shows that flagellum assembly and BBSome integrity are essential for Leishmania mexicana pathogenicity, while flagellar motility is not required for infection.

This study shows that GBPs balance iNOS and ARG-1 in myeloid cells to control Leishmania major infection, with GBPChr3 knockout mice showing increased parasite load and disease severity.

The paper sequences Leishmania tropica genomes from human skin samples in Ethiopia, identifying a new drug-resistant variant and suggesting an outbreak.

This paper develops a CRISPR base-editing library for genome-wide loss-of-function screening in Leishmania mexicana to study drug response mechanisms and identify novel biomarkers.

This study identifies and characterizes non-coding RNAs (ncRNAs) across multiple Leishmania species, revealing their genomic structure and functional roles in development and host interaction.

This study shows that drug-resistant Leishmania donovani strains exploit host lipids through enhanced endocytosis and lipid droplet accumulation, reducing their responsiveness to Amphotericin-B.

The paper investigates the role of FAZ proteins in Leishmania adhesion, showing their deletion impairs adhesion and identifies KIAP2 as a key component of novel flagellar filaments.

This paper evaluates the anti-parasitic effects of SQ109 and MeSQ109 against Leishmania mexicana and investigates their mechanism of action, including mitochondrial and acidocalcisome targeting.

This study identifies key residues in LmGAPDH critical for binding to the TNF-α mRNA 3'-UTR, showing that NAD+ binding site residues are essential for this interaction.

This study identifies hexadecanoic acid as an oviposition pheromone in Tunisian Phlebotomus papatasi sand flies, which increases egg-laying and attracts gravid females.

This study shows impaired lymphatic function contributes to non-healing cutaneous leishmaniasis caused by L. amazonensis and demonstrates that targeting lymphatics can reduce inflammation.

This study identifies increased translational activity and immune activation in lymphatic endothelial cells during cutaneous leishmaniasis.

This study shows that deleting the actin binding domain of Leishmania profilin impairs cell growth, vesicle trafficking, and mitochondrial function.

This study identifies GP63 as a Leishmania secretory factor that targets the DICER1/miR-122/hepcidin axis in macrophages to degrade Nramp1 and facilitate iron acquisition.

The paper investigates genetic diversity and sex differentiation in Lutzomyia longipalpis, identifying sex chromosomes and population structure across South America.

The paper shows that macrophage heterogeneity, including resKC-derived and monocyte-derived cells, is critical for granuloma maturation and parasite control in visceral leishmaniasis.

This study shows that VAPA facilitates lipid exchange between Leishmania amazonensis and host macrophages, essential for parasite replication and virulence.

This study uses CRISPR/Cas9 to delete the UMSBP gene in Leishmania major, resulting in attenuated parasites with reduced growth and increased apoptosis, which induce a Th1 immune response and partial protection against infection.

The paper generates a hybrid between Leishmania infantum and Leishmania tarentolae, showing genomic compatibility and transcriptomic differences driven by gene copy number and mRNA turnover.

This study shows that host inflammatory responses, not the parasite, drive HIF-α signaling in macrophages during Leishmania major infection, leading to HIF-α-dependent suppression of protein translation in a pro-inflammatory environment.

This study examines how a sub-chromosomal deletion in Leishmania infantum affects parasite virulence, transmission, and drug resistance, suggesting it may enhance geographic spread.

This study shows that eosinophils contribute to chronic cutaneous leishmaniasis by expressing a unique metabolic profile that suppresses Th1 responses.

This study shows that different Leishmania aethiopica isolates trigger distinct effector responses in human monocytes, with long-term cultured parasites eliciting different outcomes than recently isolated ones.

This study evaluates the immunopharmacological efficacy of Leishmania donovani overexpressing Ld_ζ1domain as a vaccine candidate against visceral leishmaniasis, showing reduced parasite burden and enhanced immune response.

The paper identifies a novel epsilon-tubulin in Leishmania major localized at the basal body, confirmed by CRISPR-Cas9 tagging and nocodazole treatment.

This study identifies a direct glutamate catabolism pathway in Leishmania, bypassing proline biosynthesis, and highlights differences in amino acid metabolism between Leishmania and Trypanosoma.

This study investigates how antimony-resistant Leishmania donovani strains manage iron and oxidative stress, leading to anemia, and identifies potential therapeutic targets.

This study shows that DOT1B is not essential for differentiation or macrophage infection in Leishmania mexicana, contrasting its essential role in Trypanosoma brucei.

The paper identifies a conserved long non-coding RNA in Leishmania braziliensis and shows its structural importance for parasite fitness and RNA-protein interactions.