Research on Leishmaniasis Studies

The paper identifies essential membrane transporters for Leishmania survival through a CRISPR-Cas9 gene deletion screen, finding that V-ATPase is critical for amastigote survival despite being dispensable for promastigote growth.

This study characterizes NAT10 in Leishmania mexicana, showing its nuclear localization, essentiality, and role in parasite differentiation and metabolism.

The paper identifies and validates apoptotic proteins in Leishmania donovani using computational screening, molecular docking, and CRISPR-Cas9 knock-out experiments, showing their role in parasite apoptosis.

This study shows that IL-17A-producing γδ T cells drive pathogenesis while IFN-γ-producing γδ T cells have therapeutic potential in cutaneous leishmaniasis.

The paper develops and applies species identification and insecticide resistance assays to monitor sand fly vectors in the Mediterranean and Middle East, revealing resistance mutations and species-specific responses to insecticides.

The paper analyzes the genomic diversity of Leishmania (Viannia) braziliensis across the Neotropical Realm, identifying two major parasite groups associated with different biomes and highlighting ecological and epidemiological differences.

The paper investigates how different Leishmania aethiopica isolates affect neutrophil effector functions in vitro, finding that long-term cultured isolates induce more ROS production and distinct neutrophil populations.

This study shows malnutrition worsens visceral leishmaniasis by impairing IFN-γ immunity and boosting IL-10, which is reversed by IL-10R blockade.

This paper identifies KMP-11 as a key Leishmania protein that mediates host cell invasion via cholesterol transport and membrane phase transition.

This study shows that the Leishmania donovani species complex dispersed globally within the last 2,000 years, aligning with human migration and colonization.

This study evaluates Malvidin and Echioidinin as antileishmanial agents through in vitro and in silico analyses, finding Malvidin more potent and less toxic than Echioidinin and Amphotericin B.

This study identifies an FDA-approved inhibitor that targets glycosome membrane biogenesis in Leishmania parasites, effectively killing them including amastigote forms.

This study uses a kinase inhibitor screen to identify host kinases involved in Leishmania uptake and survival in macrophages, revealing both known and novel regulators.

The paper synthesizes and evaluates 24 disquaramide compounds against Leishmania major, finding six significantly reduce parasite numbers without host toxicity.

This study examines changes in co-stimulatory and inhibitory receptors on monocyte subsets in visceral leishmaniasis patients before and after treatment.

This study shows that in vitro polarized Th1, Th2, and Th17 cells retain their cytokine profiles when challenged with OVA-expressing Leishmania major, indicating resilience to antigen manipulation.

This study uses proteomic profiling to identify 67 differentially expressed proteins in cutaneous leishmaniasis lesions compared to healthy skin, highlighting the integrated endoplasmic reticulum stress response as a key pathway.

This study identifies sorafenib and imatinib as potential anti-leishmanial drugs by targeting Leishmania MAP kinases, showing anti-proliferative effects and reduced parasitic burden.

This study compares structural and gene expression changes in spleens of visceral leishmaniasis patients with and without HIV coinfection, identifying key pathways and gene associations linked to spleen disorganization.

This study identifies and functionally characterizes a noncoding RNA in Leishmania braziliensis that influences stress response and parasite differentiation.

This study develops PCR and sequencing methods to rapidly detect and differentiate Leishmania species causing human infections.

This study identifies Chinese hamsters and Steppe lemmings as new animal models for studying Mundinia Leishmania species, showing susceptibility and infectiousness to sand flies.

The paper reports the discovery of a new Leishmania species, L. adleri, in sandflies in Spain, highlighting the need for broader surveillance to improve diagnosis and understanding of leishmaniasis in Europe.

This study uses meta-analysis of Leishmania donovani transcriptome data to identify co-regulated gene modules and reveals reciprocal regulation between two modules associated with different life phases.

This study shows that DEL-1 expression in macrophages reduces parasite burden and granuloma formation in visceral leishmaniasis, promoting an immunoprotective response.

This study investigates whether parasite genetic variation or immune responses differ among clinical presentations of cutaneous leishmaniasis caused by Leishmania aethiopica, finding no significant associations.

The paper sequenced 14 Moroccan Leishmania tropica isolates to study genomic heterogeneity, identifying a core group and two divergent strains with distinct SNP profiles.

The paper evaluates natural products for anti-leishmanial activity against Leishmania infantum MOGS using CADD, identifying Ocotillone and Subsessiline as promising candidates with pH-dependent inhibition and favorable ADMET profiles.

This study uses 3D electron microscopy to analyze Leishmania mexicana cell cycle stages, revealing organelle duplication, segregation patterns, and metabolic adaptations in different environments.