Pancreatic function and diabetes

This paper investigates the effects of Gαs ablation in the pancreas, showing reduced β-cell mass, exocrine defects, and attempted β-cell regeneration from ducts, suggesting potential therapeutic strategies for diabetes.

This study identifies Tomosyn-2 as a regulator of β-cell maturation, showing its role in balancing proliferation and function during postnatal development.

This study generates and expands human pancreatic islet organoids in vitro, which can differentiate into multiple endocrine cell types and show therapeutic potential in animal models.

This study expands and differentiates adult human pancreas-derived progenitor cells into functional islet-like organoids using clinical tissue and validates their endocrine capabilities.

The paper shows that δ-cell interactions modulate pancreatic islet Ca2+ oscillation patterns through somatostatin secretion and pharmacological/optogenetic perturbations, revealing a Hopf bifurcation mechanism.

The paper analyzes single-cell transcriptomes of human islet cells across glycemic states to identify gene expression defects in beta cells associated with type 2 diabetes.

This study identifies FXR and BET signaling cooperation in protecting β cells from diabetes-related dysfunction through protein interaction and functional synergy.

The paper uses single-cell ATAC-seq to identify chromatin accessibility changes in pancreatic β-cells following prolactin treatment, revealing OVOL2 as a novel negative regulator of PRLR signaling.

This study shows primary cilia are essential for GLP-1R signaling in pancreatic beta cells, as their loss impairs insulin secretion and cAMP/Ca2+ responses.

This study shows that Otub2 modulates pancreatic beta-cell function and survival by inhibiting NFkB signaling and regulating K+ channels involved in insulin secretion.

This study examines sex differences in human islet gene expression and mitochondrial function in type 2 diabetes, finding female islets show greater preservation of insulin content and fewer functional defects.

This paper enhances artificial beta-cells with a PID controller to improve glucose regulation in diabetic mice.

The paper identifies cell type-specific and sex-specific transcriptional dysregulation in islets of Langerhans in Down syndrome mice, linking it to increased T2D risk.

This study identifies MEF2A as a negative regulator of beta cell maturation and function, showing that its overexpression impairs beta cell identity and insulin secretion under ER stress.

This study shows that MEF2D overexpression impairs mitochondrial respiration, insulin secretion, and survival in INS-1 β-cells, while knockdown improves these functions.

The paper identifies Med14 phosphorylation as essential for sustained GLP-1 agonist-induced gene regulation in beta cells.

This study extends the integrated glucose-insulin model to include disease progression in individuals with impaired glucose tolerance, showing slower deterioration with lifestyle intervention.

The paper examines how mitochondrial proximity influences insulin secretory granule (ISG) maturation through biophysical and spatial changes in pancreatic beta cells.

The paper uses computational modeling to identify key parameters controlling glucose-induced excitability diversity in human pancreatic β-cells.

This study identifies mitochondrial-insulin granule crosstalk involving VDAC and VNUT as critical for granule maturation and insulin secretion.

This study shows hIAPP aggregation disrupts islet microvascular stability by downregulating EC genes and causing pericyte detachment, impairing vasomotor responses.

This study shows that cationic amphiphilic drugs (CADs) accumulate in insulin secretory granules via pH-dependent trapping, affecting monoamine storage and pH regulation.

This study identifies NRDC's role in regulating Slc2a2 expression in pancreatic β-cells through direct interaction with an evolutionarily conserved enhancer and ISLET1 recruitment.

This study develops a microfluidic biosensor using pancreatic islets to monitor glucose levels in vivo, showing strong correlation between islet activity and glucose concentrations.

This study shows that prolactin receptor signaling protects beta-cells from metabolic stress by maintaining incretin receptor expression and insulin secretion.

This study shows tirzepatide improves β-cell function in T2D by reversing dedifferentiation and restoring transcription factors through FOXO1 reactivation.

This paper integrates 18 scRNA-seq datasets to identify three beta-cell state trajectories linked to aging, diabetes, and metabolic stress, showing erosion of beta-cell identity programs.

This study identifies a dual-phase enhancer that maintains pancreatic progenitor cells and stabilizes lineage identity, preventing pathological plasticity and disease.

The paper uses imaging mass cytometry to analyze pancreatic duct-associated endocrine cells across age groups, finding changes in cell types and abundance linked to diabetes, obesity, and aging.

This study evaluates if single-gene knockout of RNLS or HIVEP2 can protect β-cell grafts from allo- and xenorejection, finding no protective effects.