Escherichia coli research studies

This study shows that Turicibacterales, specifically Turicibacter sanguinis, protect mice from severe Citrobacter rodentium infection by reducing susceptibility when present.

This study shows that restoring O antigen in E. coli K-12 sensitizes it to bile salts and vancomycin, suggesting bile salts drove the loss of O antigen in K-12 strains.

This paper identifies CTP as a ligand for the Shigella virulence regulator VirB, showing that CTP binding is essential for its regulatory functions and virulence phenotypes.

The paper identifies HlyF as a virulence factor in UPEC strains associated with severe UTIs and urosepsis, showing its link to plasmid-mediated virulence and antimicrobial resistance.

This study identifies host-specific genetic determinants in E. coli using genome-wide association, revealing lineage-specific adaptations to human, cattle, chicken, and pig hosts.

This study develops a low-cost recombinant glycoconjugate vaccine against ETEC O148 and O78 that provides immunogenicity and protection in mice.

This study characterizes six STEC strains from Colombia encoding the stx2 gene, identifying variations in Stx production, subtypes, and phage late region genes.

This study analyzes the genomic evolution of commensal E. coli over 30 years in France, finding increases in virulence and antibiotic resistance genes through clonal expansion and gene frequency changes within clones.

The paper analyzes the genome of an avian pathogenic Escherichia coli strain from Bangladesh to identify virulence and antimicrobial resistance genes.

This study compares serotyping and cgMLST for Shigella classification, finding that cgMLST better reflects genetic relationships.

This paper analyzes the genomic diversity and evolution of Escherichia albertii from Chinese and international isolates, revealing population structure, virulence gene distribution, and high multidrug resistance prevalence.

The paper develops a long-read sequencing method to identify and distinguish AIEC strains in intestinal tissue, showing their ability to colonize IBD-susceptible mice and induce inflammation.

This study shows that D-serine induces distinct transcriptional responses in three Escherichia coli pathotypes, with no common differentially expressed genes across all strains.

The paper investigates the structural dynamics of SctV, a component of the Type III translocase export gate in E. coli, revealing its conformational changes and interactions with chaperones and ATPase.

The paper generates high-quality reference genomes for seven major ETEC lineages using long-read sequencing, revealing conserved virulence plasmids crucial for pathogenesis.

This study analyzes genome rearrangements in Shigella and E. coli strains, finding high rearrangement rates and specific E3 ubiquitin ligases linked to pathogenicity.

The paper reports the structure of an active Salmonella T3SS needle complex engaged with SptP, revealing the mechanism of unfolded protein translocation through the secretion conduit.

This study analyzes over 100,000 E. coli genomes to identify 14 phylogroups, revealing population structure and genomic adaptations in virulence and antibiotic resistance.

This paper develops a nanopore sequencing workflow to detect and assemble Shiga toxin-producing E. coli in irrigation water, demonstrating its effectiveness for food safety applications.

This paper curates a high-quality collection of over 10,000 E. coli and Shigella genomes to facilitate analysis of genetic diversity and lineage differences.

This study characterizes the genomic diversity of Escherichia coli isolates from backyard chickens and guinea fowl in rural Gambia, identifying novel sequence types and antimicrobial resistance genes.

This study analyzes genomic diversity and antimicrobial resistance in Escherichia coli isolates from non-human primates in the Gambia, identifying novel sequence types and potential human pathogen exchange.

The paper implements an in silico Clermont PCR method for E. coli phylotyping as a web app and command-line tool.

The paper compares stx2a-encoding prophages in UK STEC O157:H7 sub-lineages, finding high diversity and independent acquisition, while stx2c-encoding prophages show vertical inheritance.

The paper compares long-read sequencing methods to detect plasmids, virulence genes, and phages in STEC strains, finding MinION sequencing effective for genome closure and marker identification.

The paper analyzes whole-genome sequences of 16 ExPEC ST73 isolates from a single hospital to identify circulating clonal groups and their mobile genetic elements.

The paper compares E. coli isolates from humans and livestock to assess transmission and resistance gene sharing, finding genetic distinctions and limited shared antimicrobial resistance genes.

The paper investigates the MPEC pathotype hypothesis by comparing genomes of bovine mastitis-associated E. coli and commensal isolates, finding no specific pathogenic traits unique to MAEC.