Sleep and Wakefulness Research

This study investigates how PACAP and CRF, two stress peptides, affect sleep architecture in mice, finding distinct impacts on sleep stages and behavior.

The paper investigates how estrogen receptors directly regulate hypocretin expression in the hypothalamus, linking estrogen to sex-specific depression mechanisms.

This study identifies a novel role for phospholamban in regulating thalamic reticular nucleus function, linking it to behavioral phenotypes like hyperactivity and sleep disturbances in mice.

The paper studies sleep-wake abnormalities in a new PD mouse model and finds they mirror human PD symptoms, suggesting potential for understanding and treating sleep disruptions in PD.

This study examines the differential degeneration of wake- and sleep-modulating neurons in Alzheimer's disease, finding significant loss of orexinergic neurons and relative preservation of MCHergic neurons.

The paper identifies sex-specific transcriptomic changes in the cerebral cortex of male and female mice after sleep deprivation, highlighting differential regulation of genes like Bdnf and Fosb.

This study investigates the relationship between sleep spindles and memory consolidation in Parkinson's disease patients, finding that lower spindle density and reduced temporal clustering are associated with worse memory consolidation.

The paper shows wake EEG oscillation amplitudes and aperiodic offsets correlate with sleep slow waves, reflecting sleep pressure and brain maturation across childhood and adolescence.

This study shows that Kir6.2-KATP channels regulate glycolytic flux, neuronal activity, and sleep-wake transitions by modulating lactate dynamics and metabolic stability.

The paper identifies a half-centre oscillator in Drosophila that generates slow-wave activity linked to sleep regulation and pressure.

The paper identifies individualized temporal patterns as the main determinant of sleep spindle timing in humans, using data from 1008 participants.

The paper finds that longer self-reported sleep duration in men is linked to better virtual spatial navigation performance, while no such association is found in women.

This study analyzes EEG spectral and microstate patterns in RISP patients during non-episodic sleep, finding increased theta power and altered microstate transitions compared to controls.

This study investigates ultradian rhythms in sleep and wakefulness in rats after sleep deprivation, finding that rebounds in wakefulness and NREM sleep depend on full ultradian cycles and are mediated by changes in ultradian phase duration and arousal probability.

The paper analyzes the spectral dynamics during the NREM to REM sleep transition in rats, identifying specific power changes in different brain regions that precede REM sleep onset.

This study shows that sleep deprivation after fear conditioning reduces fear memories in mice, possibly through BDNF-mediated neuroadaptations in the amygdala.

The paper introduces a visual paired association learning paradigm to study memory consolidation during sleep and finds that naps improve recognition memory stability but not cued recall.

This study shows that embryonic and postnatally-derived brain macrophages have distinct roles in regulating sleep-wake cycles and synaptic balance, with postnatal repopulation failing to restore normal sleep patterns.

This study examines how spontaneous oxycodone withdrawal affects sleep, circadian rhythms, and EEG dynamics in rats over time.

This study shows that odor cueing during sleep increases sleep spindles and slow oscillations, which may enhance declarative memory consolidation.

Somnotate is a probabilistic classifier that improves sleep stage annotation in mice by identifying intermediate states and transitions, outperforming human experts.

This study investigates how phase-specific targeted memory reactivation during sleep affects motor memory consolidation, finding that up-state cues improve performance and alter neural activity.

This study shows that APP processing into Aβ40 and Aβ42 is conserved in zebrafish and that disrupting this processing affects sleep maintenance.

This study shows that miR-709 regulates NREM sleep EEG slow waves by linking glutamatergic signaling to neuronal activity through endosomal trafficking.

The paper shows that sleep spindles cluster in NREM2 sleep, supporting motor memory consolidation through synchronized oscillatory activity.

The paper shows sleep selectively enhances sequence memory for real-world experiences over time, with effects growing up to one year post-encoding.

This study uses a new branched in situ hybridization chain reaction technique to map orexin receptor mRNA expression in mouse brains, revealing distinct distributions and cell types expressing OX1R and OX2R.

The paper investigates diurnal changes in brain anatomy using voxel-based morphometry and links them to sleep characteristics in a large dataset.

This study shows that sleep restores criticality in cortical networks, a computational regime that optimizes information processing, more accurately than traditional measures like SWA.

This study shows that chemogenetic activation of astrocytes in specific brain regions affects sleep/wakefulness states and cortical oscillations differently.