Inflammasome and immune disorders

This paper shows that Coxiella burnetii uses its lipid A acylation pattern to avoid activating the non-canonical inflammasome in macrophages, thereby evading immune detection and clearance.

The paper develops a CRISPR-based IL-1β reporter assay to identify tolcapone as a caspase-1 inhibitor that suppresses pyroptosis in endotoxemia.

This study identifies a non-canonical pyroptosis pathway in cartilaginous fish involving GSDMA/B cleavage by LPS-activated caspase-1, revealing dual-fragment regulation and antimicrobial activity.

This study shows NEK7 accelerates NLRP3 inflammasome activation but is not essential, suggesting potential limitations in targeting this interaction for drug development.

This study shows that chitin oligomers of specific lengths activate the NLRP3 inflammasome and induce innate immune training through phagocytosis and methyl transferase activity.

This study shows that inhibiting the NLRP3 inflammasome prevents hyperglycemia in a humanized mouse model of type 2 diabetes.

This study shows that linear ubiquitination, mediated by LUBAC, is essential for the execution phase of NLRP3-mediated pyroptosis, independent of priming.

This paper identifies how Yersinia pestis YopM binds the human pyrin death domain to inhibit inflammasome activation and shows that this interaction is critical for its virulence.

OLT1177 inhibits IL-1β release and pyroptotic cell death in LPS-treated BMDMs by blocking caspase-1 and GSDMD activation.

This study shows that GSDMD limits host resistance to Toxoplasma gondii while NINJ1 promotes protection, revealing opposing roles of pyroptotic effectors in IL-1β-dependent immunity.

This study activates the NLRP1 inflammasome in skin equivalents to reveal a novel signaling axis involving IL-1 and IL-36γ in psoriasis.

This study identifies PKCδ agonism as a method to selectively induce pyroptosis in NF1-deficient cells by targeting KRAS-GDP interactions.

S. anginosus replicates intracellularly within macrophages and is sensed by the NLRP3 inflammasome to promote proinflammatory response.

This study investigates the role of NLRP3 inflammasome and microglial pyroptosis in EcoHIV-infected mice, showing increased NLRP3 and GSDMD expression and reduced markers with MCC950 treatment.

This study identifies CASP4/5 as activators of CASP3/7 and GSDME in human macrophages, showing that CASP3 restricts Salmonella replication through apoptosis.

This study shows chronic NLRP3 inflammasome activation leads to neutrophil entry into the brain and interactions with microglia, contributing to CNS pathology.

The paper identifies mutant NLRP1 in mast cell granules in keratoacanthomas associated with multiple self-healing palmoplantar carcinoma, showing overpopulation and degranulation of mast cells expressing the A66V variant.

This study uses mass spectrometry to identify caspase targets in primary intestinal epithelial cells following NAIP-NLRC4 inflammasome activation, revealing novel cleavage sites beyond known Caspase-1 substrates.

This study reports a novel mode of NLRP3 activation in zebrafish through cryo-EM structure analysis, revealing a distinct oligomeric arrangement and activation mechanism compared to humans.

This study shows that broad-spectrum cathepsin inhibitors block crystal-induced inflammation and gout arthritis by inhibiting both inflammasome-dependent and -independent pathways that generate IL-1β.

This paper shows that TH5487 and SU0268 inhibit NLRP3 activation in FCAS patient PBMCs, overcoming resistance to MCC950 by blocking inflammasome assembly and reducing IL-1β secretion.

This study identifies caspase-14 as a processor of IL-1β in epithelial cells that drives anti-bacterial IgG production against Yersinia pseudotuberculosis infection.

This study shows inflammasome activation causes necrotic cell death in macrophages without gasdermin D or E by clustering ninjurin-1, leading to plasma membrane rupture and IL-1β release.

This study shows that GSDMA undergoes S-acylation, which promotes pyroptosis by enhancing membrane anchoring and oligomerization, distinct from GSDMD's palmitoylation mechanism.

This study identifies hResistin's role in priming and activating the NLRP3 inflammasome in macrophages, linking it to inflammatory diseases through HMGB1, BTK, and downstream cytokine production.

This study identifies MEX3B as a positive regulator of multiple inflammasomes, showing its role in caspase activation, pyroptosis, and cytokine secretion across different cell types.

This study uses cryo-ET to visualize NLRP3 inflammasome condensates at the MTOC during activation, revealing structural changes and pyroptosis in macrophages.

This study shows AIM2 forms DNA-induced condensates that drive immune activation and regulation through inflammasome and PANoptosome assembly.

This study shows that NLRP3 inhibition reduces blood pressure in male DOCA-salt rats but not females, while decreasing T cell levels in both sexes.

This study shows that MG53 reduces intestinal inflammation by inhibiting NLRP3 inflammasome activation in colitis models.