Adenosine and Purinergic Signaling

This study examines ATP and dopamine co-release in the nucleus accumbens using FSCV, showing their coupled release and shared regulatory mechanisms.

This study identifies an adenosine-Gzmk axis that drives T cell aging and systemic inflammaging, showing that targeting it can reverse aging phenotypes and extend lifespan in mice.

This study creates a platelet-specific P2Y1 receptor knockout mouse model and shows it suppresses leukocyte recruitment during inflammation.

This paper introduces an optimized method to measure extracellular ATP in human airway samples, showing improved stability and specificity for eATP quantification.

This study shows that inhibiting P2Y6 receptors reduces renal fibrosis in mice by preventing fibroblast activation and migration.

The paper introduces X7-uP, a chemical labeling reagent for P2X7 receptors, enabling super-resolution imaging of their nanoscale redistribution in BV2 microglial cells during activation.

The paper reports the cryo-EM structure of the human P2X3 receptor complexed with sivopixant, revealing subtype-specific allosteric inhibition mechanisms and structural basis for improved selectivity.

This study shows ATP increases murine neuroblastoma cell size via PANX1-dependent macropinocytosis, with PANX1 internalization and lipid interactions involved.

This study investigates the antiepileptic and neuroprotective effects of A1 adenosine receptor agonists and modulators in various models of hyperexcitation, showing their ability to suppress seizures and improve survival.

This study shows jasmonate primes plant responses to extracellular ATP via P2K1, enhancing calcium elevation and transcriptional reprogramming in a JA signaling-dependent manner.

The paper presents cryo-EM structures of the human A3 adenosine receptor in three functional states, revealing a unique activation mechanism and a cryptic binding pocket.

This study shows that A2AR inhibition enhances B cell maturation into antibody-secreting cells in the tumor microenvironment, reversing immune suppression.

The paper uses Bayesian inference and molecular dynamics to show asymmetric coupling in P2X2 receptors, explaining negative cooperativity and the flip state.

This study shows that P2Y2 receptors are essential for hepatic clearance of uropathogenic E. coli, leading to improved survival in a murine sepsis model.

This study examines the spatiotemporal expression of CD73 in the mouse retina across development and adulthood, revealing its role in retinal function and adenosine signaling.

This study identifies P2RX7 as a key regulator of Treg suppressive function in lung tumors, showing that targeting P2RX7 could improve lung cancer treatment by reducing Treg-mediated immune suppression.

This paper demonstrates on-cell STD NMR for studying P2X7 receptor-ligand interactions, providing binding epitope maps and 3D models for two antagonists.

This study shows that adenosine 2B receptor signaling impairs neutrophil killing of antibody-opsonized pneumococci in young vaccinated mice, reducing vaccine efficacy, but not in aged mice.

This paper characterizes [3H]AZ12464237 as a high-affinity radioligand for the P2Y12 receptor, showing selectivity and utility in in vitro studies.

This study shows that the Panx11-89 mutant forms a functional ATP release channel independently of wild-type Panx1, with conserved structure-function features and sensitivity to inhibitors.

This study identifies phosphorylation as a switch that stabilizes Pannexin1 in an ATP-releasing conformation, important for developing disease modulators.

The paper identifies molecular features of the human P2X7 receptor using cryo-EM structures and designs a potent, selective antagonist, UB-MBX-46, with picomolar potency and high selectivity.

This study investigates how oxidative stress affects the structure, activity, and signaling of the Adenosine A2a Receptor (A2aR), finding no structural impact but increased cAMP levels in response to agonists under oxidative conditions.

This study shows ATP and glutamate work together in freshwater sponges to trigger whole-body contractions, suggesting ancient signaling mechanisms predating nervous systems.

The paper identifies potent A2AR negative allosteric modulators through high-throughput screening and SAR analysis, showing their efficacy in high-adenosine conditions for safer cancer immunotherapies.

The paper identifies extracellular nucleotides ATP and UTP as drivers of epithelial contractility in Xenopus embryos, mediated by the P2Y2 receptor.

The paper reports cryo-EM structures of human P2X4 receptor in different states, revealing the cytoplasmic cap forms before agonist binding and is stabilized by lipids, with unique allosteric features for modulator development.

The study identifies ATP-sensitive P2X5 isoforms and transcript variants in multiple species, challenging the assumption of their ATP-insensitivity.

This study identifies differential expression and functional roles of ectonucleotidases and purinergic receptors in mouse prostate cells, revealing their involvement in smooth muscle contraction and potential relevance to prostate diseases.