Ion Channels and Receptors

The paper investigates the distribution of TRP channels in human oral tissues to understand their role in environmental sensing.

This study investigates whether TMEM150c forms a mechanosensitive ion channel or is required for mechanosensitivity in sensory neurons, finding no evidence to support these claims.

The paper investigates the roles of PEZO-1 and TRP-4 mechanosensors in C. elegans mating behavior, showing their involvement in multiple mating steps and mechanosensory functions.

This study identifies modality-specific roles for metabotropic GABAergic signaling and calcium-induced calcium release in regulating cold nociception in Drosophila CIII neurons.

This study identifies Piezo1 as the major mechanotransducer in keratinocytes for detecting mechanical stimuli and transmitting tactile information to sensory neurons.

The paper shows TACAN inhibits Piezo2 channel activity in DRG neurons without affecting Piezo1 or TREK1 currents.

This study identifies a role for peripheral kappa opioid receptors in driving cold hypersensitivity through modulation of TRPA1 channels in mice.

This study shows that Gq-coupled receptor activation induces oscillatory calcium signaling in hOPCs, which blocks differentiation and promotes proliferation through SOCE, suggesting potential therapeutic targets for myelin repair.

This paper demonstrates that expressing human TRPA1 channels in neurons allows ultrasound to control neural activity in the intact mammalian brain.

The paper shows TRPV1-lineage fibers communicate with parabrachial taste neurons, integrating somatosensory and gustatory signals in mice.

This study identifies distinct pezo-1 isoforms in C. elegans with tissue-specific expression and functional roles in food intake regulation.

The paper combines mechanosensitive current recordings with single-cell RNA sequencing in mouse DRG neurons to identify candidate genes for mechanosensory functions.

This study shows that RTX reduces nocifensive response in C. elegans to noxious heat and identifies Wnt signaling as a pathway involved.

This study shows that blocking TRPA1 protects white matter function during ischaemia in the mouse optic nerve by preventing loss of compound action potentials.

This study identifies DIMTA, a marine tunicate metabolite, as a selective inhibitor of cold thermosensors in mice, increasing cold sensation threshold by >3°C.

This study identifies JNK as a post-translational regulator of ASIC1b and ASIC3 channels in sensory neurons, showing its role in pain hypersensitivity.

This study identifies FAM19A5l in zebrafish as a regulator of mustard oil-induced nociception by modulating TRPA1b and NGFa expression.

The paper identifies Piezo2 expression in neuronal and non-neuronal cells of the rat peripheral sensory pathway and links its elevation to pain conditions.

The paper shows T-type channels are essential for leptin-induced depolarization and excitability in POMC neurons, mediated through a TRPC1/C5-CaV3 complex.

The paper identifies a new population of PKD2L1-positive neurons in the ventromedial spinal cord and medulla of adult mice that are distant from the central canal but share properties with CSF-contacting neurons.

This study identifies TRPC5 as a mediator of inflammatory mechanical pain using knockout mice and pharmacological inhibitors, showing its role in pain behaviors induced by lysophosphatidylcholine.

This study identifies TRPM channels as mediators of learned pathogen avoidance in C. elegans following intestinal distention caused by bacterial colonization.

The paper investigates pruriception and neuronal coding in nociceptor subtypes in humans and nonhuman primates, finding differences in pruritogen activation and responses compared to rodents.

The paper identifies TRPA1 channels in brain capillary endothelial cells as key initiators of neurovascular coupling by generating retrograde signals that dilate upstream arterioles.

This study identifies JPH4 as essential for ER-PM junction formation and inflammatory pain through SOCE and Ca2+ signaling in rat DRG neurons.

The paper identifies COX2 upregulation as a novel mechanism mediating TRPV1 sensitisation in cultured murine primary sensory neurons within 30 minutes.

The paper shows that TrpML-mediated astrocyte microdomain Ca2+ transients regulate tracheal filopodial retraction and CNS gas exchange in Drosophila.

The paper reports the cryo-EM structure of human TRPC5 bound to the xanthine inhibitor Pico145, revealing its interaction with a conserved lipid binding site and elucidating the mechanism of TRPC1/4/5 modulation.

The paper shows that TAM and STRMK mutations in STIM1 cause similar functional defects leading to excessive Ca2+ entry and shared pathomechanisms.

The paper uses molecular profiling to show that visceral afferents from different ganglia have distinct gene expression patterns, indicating functional specialization and integration of sensory information.