Neuroinflammation and Neurodegeneration Mechanisms

The paper identifies and characterizes LYVE-1+ perivascular macrophages in the mouse brain, showing their regional distribution, developmental dynamics, and reduced density in Alzheimer's disease model.

This study shows that Canagliflozin improves central insulin sensitivity and reduces neuroinflammation in aged male mice but not females, suggesting sex-specific neuroprotective effects.

This paper introduces a non-invasive diffusion MRI method to image microglia and astrocyte activation in vivo, showing it can detect glia proliferation and correlate with histological markers in humans.

This study shows that SALL1 is necessary for the developmental transition of microglia from an immature to mature state in mouse embryos.

The paper investigates how epigenetic changes in microglia influence their response to inflammatory and genotoxic stress, identifying distinct gene networks and functional phenotypes.

This study examines the relationship between sTREM2 and inflammatory activity in early stage Alzheimer's disease using clinical and biomarker-defined groups.

This study shows that reduced TREM2 proteolytic cleavage in mice increases microglial heterogeneity and accelerates Abeta pathology in Alzheimer's disease.

The paper investigates how interactions with apoptotic neurons influence microglial states and survival pathway dependence using scRNAseq in mouse retina.

The paper assesses the transcriptional response of in vitro innate immune cell models to synthetic amyloid beta and finds no robust response, but identifies LPS and INFγ as better activators of microglia-like cells.

The paper shows that microglia in specific brain regions exhibit premature aging-related inflammation in middle age, which may affect nearby neurons.

The paper investigates how microglia morphology differs between rat lines with distinct emotional temperaments and links these differences to baseline microglial reactivity.

This study integrates human iPSC-derived microglia into midbrain organoids, enhancing neuronal maturation and functionality through effects on synaptic remodeling and excitability.

The paper analyzes the co-expression patterns of Iba1, TMEM119, and P2RY12 in microglia from Alzheimer's patients and controls, finding differences in marker combinations associated with disease pathology.

This study shows that an obesogenic diet affects hippocampal structure and function in rats, with NRG1 administration altering these effects through the TACE/ADAM17-NRG1-ErbB4 signaling pathway.

This study shows that atmospheric particulate matter worsens CNS demyelination by activating TLR-4/NF-κB signaling in microglia, leading to neuroinflammation and myelin injury.

This study shows that TREM2 loss in human iPSC-derived microglia leads to altered Ca2+ signaling and motility via purinergic receptor pathways.

This paper introduces a method to eliminate microglia in glial cultures without affecting astrocytes using TSA, enabling the study of their distinct roles in immune responses.

The paper uses microPET imaging to show that gp120 transgenic mice exhibit heightened neuroinflammation in response to LPS compared to wildtype mice, mirroring HIV-related hypersensitivity in PLWH.

This study identifies microglia as key regulators of cerebral blood flow and neurovascular coupling through P2Y12R-mediated mechanisms in mice and humans.

The paper analyzes the transcriptome of human microglia across brain regions, aging, and disease to identify genetic effects on gene expression and splicing, linking them to neurological disorders.

This study compares transcriptomes of human iPSC-derived microglia generated by different methods to assess their ability to model microglia heterogeneity in ALS.

This study identifies a novel interaction between TREM2 and TDP-43, showing TREM2 mediates microglial neuroprotection against TDP-43-related neurodegeneration.

This study shows that reactive astrocytes are necessary for promoting beneficial plasticity after ischemic stroke in mice, as their absence leads to impaired recovery and maladaptive connectivity changes.

This study examines the transcriptomic response of human monocyte-derived microglia-like cells to Aβ1-42 oligomers, finding increased metallothionein expression and no inflammatory or HAM/DAM profiles.

This study identifies transcriptional mechanisms regulating microglial proliferation in development and disease models, revealing two modes of gene regulation.

This paper develops a method to generate adult-like microglial cells from mouse embryos, showing improved functionality and gene expression compared to neonatal microglia.

This study shows that repeated HPβCD treatment reduces chronic inflammation and cognitive decline after stroke by modulating lipid metabolism and immune responses.

MGEnrichment provides a web tool for analyzing gene expression data against curated microglia gene lists to assess enrichment and relevance in neuro-immunology research.

This study uses 3D cortical microtissues to show that lipopolysaccharide induces functional connectivity changes and disrupts community structure in neural microcircuits.