Neuroinflammation and Neurodegeneration Mechanisms

Impaired microglia-mediated synaptic pruning in the nucleus accumbens during adolescence results in persistent dysregulation of familiar, but not novel social interactions in sex-specific ways

Microglia-mediated synaptic pruning in the nucleus accumbens during adolescence: A preliminary study of the proteomic consequences and putative female-specific pruning target

The paper investigates proteomic changes in the nucleus accumbens during adolescent microglia-mediated synaptic pruning, identifying a potential female-specific target, Lynx1.

Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimers disease

The paper shows genetic context influences microglia-synaptic interactions in AD mouse models, with differential effects in B6 and PWK strains.

Atrophic astrocytes in aged marmosets present tau hyperphosphorylation, RNA oxidation, and DNA fragmentation

Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults

The paper examines the association between plasma TGF-β1 levels and hippocampal structure in older adults, finding a positive correlation with memory performance.

Microglial colonisation of the developing brain is facilitated by clonal expansion of highly proliferative progenitors and follows an allometric scaling

This study investigates microglial colonisation during brain development, showing clonal expansion of proliferative progenitors and an allometric scaling of microglia density.

Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain

The paper shows IFN-γ induces MHC-I expression in ventral midbrain neurons and glia, but with lower amplitude in neurons, and MHC-II is restricted to microglia.

Exercise improved P2Y12-regulated microglial dynamics during stroke via endocannabinoid signaling

This study shows that exercise enhances P2Y12-regulated microglial dynamics and neuroprotection via endocannabinoid signaling in a stroke model.

Changes to Astrocyte-associated Protein Expression at Different Timepoints of Cuprizone Treatment

The paper measures changes in astrocyte-associated protein expression at different timepoints during cuprizone treatment, finding non-linear increases in A1 and A2 markers.

Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke

The paper analyzes the translatome of astrocytes and microglia after stroke to identify their distinct roles in inflammation during hyperacute and acute phases.

Naive Huntington's disease microglia mount a normal response to inflammatory stimuli but display impaired development of innate immune tolerance that can be counteracted by ganglioside GM1

This study shows that naive HD microglia respond normally to inflammation but have impaired tolerance development, which can be reversed by GM1.

Female and male microglia are not different in the dentate gyrus of postnatal day 10 mice

The paper assesses sex differences in microglia in the dentate gyrus of P10 mice and finds no sex differences in number, density, or morphology.

Neuronal pentraxin Nptx2 regulates complement activity in the brain

This study identifies Nptx2 as a regulator of complement activity in the brain, showing its role in preventing microglial synapse elimination in health and disease.

Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain

This study shows that delivering IL2 to the brain in aging mice partially restores molecular signatures of aging and improves spatial learning.

Proximity Proteome Analysis Reveals Novel TREM2 Interactors in the ER-Mitochondria Interface of Human Microglia

The paper identifies novel TREM2 interactors at the ER-mitochondria interface in human microglia using TurboID proximity labeling, revealing a role for TREM2 in MERC structural plasticity and potential involvement in Alzheimer's disease.

TREM2-dependent senescent microglia conserved in aging and Alzheimer's disease

The paper identifies TREM2-dependent senescent microglia in aging and Alzheimer's disease, showing that TREM2 inhibition reduces their abundance and improves cognitive deficits.

ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-Like Receptor 4 in Microglia

This study shows that blocking ACAT1 in microglia reduces LPS-induced neuroinflammation by altering TLR4 trafficking and degradation.

Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis

The paper investigates how Th17 cytokines influence microglial and blood-brain barrier responses during post-infectious encephalitis using single-cell RNA sequencing and spatial transcriptomics.

Diet-induced glial insulin resistance impairs the clearance of neuronal debris

This study shows that an obesogenic diet causes glial insulin resistance in Drosophila, which impairs neuronal debris clearance.

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with hyperphagocytosis and inflammatory neurodegeneration

This study shows that brain injury accelerates age-related microglial changes linked to hyperphagocytosis and neurodegeneration in old mice.

Electrophysiological Activity of Primary Cortical Neuron-Glia Mixed Cultures

This study compares neural network activity in tri-cultures and co-cultures of cortical neurons, astrocytes, and microglia, finding that tri-cultures better mimic in vivo neuroinflammatory responses and have a more accurate E/I ratio.

Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus

This study investigates the molecular changes in the murine hypothalamus following Influenza A virus infection using single-nucleus RNA sequencing, revealing transcriptional responses in cell populations and immune-related gene activity shifts.

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

This study investigates how APOE4 affects microglial immunometabolism across age, amyloid pathology, and inflammation using multi-omics approaches.

INPP5D/SHIP1 regulates inflammasome activation in human microglia

This study shows that INPP5D/SHIP1 regulates inflammasome activation in human microglia, with reduced INPP5D leading to increased IL-1β and IL-18 secretion.

Myeloid deficiency of the intrinsic clock protein Bmal1 accelerates cognitive aging by disrupting microglial synaptic pruning

This study shows that Bmal1 deficiency in myeloid cells disrupts microglial synaptic pruning, accelerates cognitive aging, and affects sleep-wake cycles in mice.

A Trem2*R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

A dynamic balance between neuronal death and clearance after acute brain injury

The paper shows that after acute brain injury, microglial phagocytosis becomes overwhelmed, leading to a buildup of dying neurons and highlighting the need for longitudinal assays to accurately measure cell death.

BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer's disease and other disorders of lipid-rich tissues

This study identifies BHLHE40/41 as key regulators of macrophage/microglia responses in Alzheimer's disease and other lipid-rich tissue disorders through sc/nRNA-seq analysis and functional validation.

Microglia motility depends on neuronal activity andpromotes structural plasticity in the hippocampus

This study shows that microglia motility depends on neuronal activity and promotes synaptic plasticity in the hippocampus of awake mice.

ApoE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes

This study shows that ApoE4 alters astrocyte immunometabolic responses to inflammation by changing their transcriptional profiles and relying on cRel transcription factor activity.