Invertebrate Immune Response Mechanisms

This study identifies pathways modulating plasmatocyte subpopulations in Drosophila, showing that efferocytosis and Ecdysone receptor signaling shape their identity and function.

This study shows that DNA damage from Caspase-Activated DNase is essential for macrophage differentiation in Drosophila.

This study analyzes TE expression in Drosophila melanogaster during infections and finds that pathogen type has a larger effect on TE expression than host factors.

This study shows that mosGILT in Anopheles gambiae affects immune genes and zpg expression, linking it to ovarian development and Plasmodium infection.

This study shows that Gcn5 and mTORC1 regulate autophagy in Drosophila blood cell homeostasis through genetic and chemical perturbation analysis.

This study shows that loss of Drosophila N-glycanase 1 causes gut barrier defects, leading to immune activation and lipid catabolism, which contribute to lethality through non-infectious mechanisms.

The paper identifies RdRP-dependent sRNA pathways in ticks that regulate immune response by controlling an ERK pathway component, revealing a novel mechanism of antiviral immunity suppression.

This study uses long-term live imaging in flies to reveal distinct kinetics of blood cell differentiation and shows how infection modulates these kinetics to activate hematopoiesis.

This study shows that a single amino acid polymorphism in the Drosophila AMP Mtk affects systemic immunity and life history traits differently in males and females.

The paper investigates the role of Toll and spaetzle genes in Toll pathway-dependent antimicrobial gene induction in Tribolium castaneum using RNA interference and qRT-PCR, finding that Toll3 and Toll4 significantly affect AMP gene expression and immune response.

The paper examines genetic variation in immune defense against Lysinibacillus fusiformis in three Drosophila populations, finding little overlap in genetic architecture but shared QTL for resistance to two pathogens.

The paper identifies a family of immunoglobulin superfamily genes in the cnidarian Hydractinia symbiolongicarpus, showing they are homologous to vertebrate histocompatibility genes and suggest an ancient origin of V-set domains.

This study compares the immune response of noble and marbled crayfish to different strains of Aphanomyces astaci, revealing distinct gene expression patterns and immune tolerance in marbled crayfish.

The paper identifies three novel immune response genes in C. elegans by using a more suitable control strain, P. aeruginosa z11, instead of E. coli OP50.

The paper withdraws due to insufficient data and experimental evidence, acknowledging limitations in single-cell transcriptomics and in situ hybridization.

The paper identifies conserved gene expression changes and transcription factor binding sites in Drosophila melanogaster across diverse immune responses to pathogens.

The paper compares gene expression responses to microbial infection in two C. elegans isolates, finding isolate- and pathogen-specific differences in gene expression.

The paper investigates injury-induced inflammatory signaling and hematopoiesis in Drosophila larvae, identifying Toll and JNK signaling activation and the role of Upd3 in lamellocyte differentiation.

This study shows that SUMOylation of Jra in Drosophila modulates the gut immune response to Pseudomonas entomophila by regulating gene expression and immune signaling.

The paper examines genetic variation in the Intracellular Pathogen Response (IPR) in C. elegans, finding balancing selection in key regulators and showing haplotype-specific antiviral defense.

This study identifies Pvf2 as a key regulator of macrophage self-renewal in Drosophila by showing its transient expression in blood cells and its role in driving population expansion.

The paper shows Drosophila hemocytes recognize mxc mutant lymph gland tumors, activate the Toll pathway via reactive oxygen species, and induce antimicrobial peptides in the fat body.

The paper shows ecdysone regulates antimicrobial peptide expression during Drosophila metamorphosis, linking hormonal signaling to immune function and bacterial control.

This study identifies Pvr and Pvf1 as essential for hemocyte spreading at Drosophila larval wound sites and identifies downstream factors involved in wound responses.

This study shows parasitic nematode fatty acid- and retinol-binding proteins (FARs) suppress host immunity by modulating lipid signaling pathways and reducing antimicrobial peptide production in flies.

This study shows Zika virus infection increases Aedes aegypti histone acetyltransferase CBP activity, enhancing immune gene expression and reducing viral titers.

This study shows that haemocyte ablation in Drosophila melanogaster causes pupal lethality even under axenic conditions, indicating a critical role in post-embryonic development beyond microbiota control.

The paper characterizes the Drosophila adult hematopoietic system, identifying a rare cell population with differentiation and proliferation potential in response to infection.

This study investigates the genetic basis of Drosophila melanogaster's defense against Beauveria bassiana using QTL mapping and evolve and resequence approaches, revealing genetic variation and trade-offs in immune defense.

This study shows Relish in Drosophila hematopoietic niche modulates blood progenitor homeostasis during development and infection by regulating cytoskeletal architecture and differentiation.