Invertebrate Immune Response Mechanisms

The paper characterizes mosquito hemocytes using genetic markers and morphological properties, identifying twelve distinct populations in Anopheles gambiae.

The paper identifies and characterizes a diverse family of allorecognition receptors in Botryllus schlosseri, revealing their genetic complexity and conserved signaling mechanisms.

The paper compares methods for assessing pathogenicity using Drosophila and Providencia bacteria, highlighting advantages and limitations of different statistical approaches.

This study shows that inhibiting translation initiation in C. elegans increases survival during P. aeruginosa infection, while inhibiting elongation decreases survival, due to distinct immune responses.

This study tracks the progression of OrV infection in C. elegans, identifying four infection stages and gene expression changes, revealing virus-specific and general immune responses.

This study shows that Drosophila larvae use taste receptors to detect bacteria, which primes their immune system and improves survival after infection.

The paper uses a genome-wide CRISPR screen in Anopheles mosquito cells to identify essential genes and factors involved in clodronate liposome function.

This study manually annotates and refines gene models of the Toll pathway in 19 anopheline and 2 culicine mosquito genomes, revealing evolutionary constraints and radiation patterns.

This study expands and ablates Drosophila haemocytes using genetic tools, finding no effect on adult lifespan or infection resistance but observing pupal lethality in specific genetic backgrounds.

This study shows that Relish mediates the innate immune response in Drosophila S2 cells to Micrococcus luteus, with lesser effects on Bacillus subtilis and Metarhizium anisopliae.

The paper investigates bed bug immune responses to three bacterial challenges using transcriptomics and phylogenetic analysis, finding differential gene expression patterns and lineage-specific gene duplications.

This study shows that elevated temperatures enhance antiviral defenses in arthropods by activating HSF1 to upregulate antimicrobial peptides targeting viral envelopes.

This study shows that late-stage Plasmodium parasites in mosquitoes are susceptible to melanization, with distinct immune regulation for different stages.

The paper detects known and novel viruses in black soldier flies and identifies antiviral gene expression differences.

This study compares sex-dimorphic immune gene expression in two Drosophila species, finding conserved upregulation but divergent downregulation patterns in response to bacterial infection.

The paper characterizes immune cells in Pacific oysters using single-cell RNA sequencing and other methods, identifying seven functionally distinct cell types and three hematopoietic lineages.

This study identifies DRH-1 as a C. elegans RIG-I-like receptor that uses 2CARD domains to activate anti-viral immunity in intestinal cells, showing parallels with mammalian RIG-I signaling.

The paper reports genotype-specific expression of uncle fester in botryllid ascidians, showing it correlates with rejection response speed and severity, suggesting a role in allorecognition education.

The paper hypothesizes that the innate immune system limits insect body size by restricting the effective number of blood cells through division of labor.

This study shows that autophagy regulates Notch levels in Drosophila blood cell differentiation by modulating lysosomal degradation in response to nutrient availability.

This study identifies JAK/STAT, GATA, and NF-κB pathways as regulators of lectin-24A, a gene involved in Drosophila's humoral immune response to parasitoid wasps.

This study shows acid-treated Staphylococcus aureus induces melanization in silkworm hemolymph, with S. aureus proteins playing a role in innate immune activation.

This study investigates how the sex-determining gene transformer (tra) regulates sex differences in innate immunity in Drosophila melanogaster by analyzing gene expression changes in response to bacterial infection.

The paper identifies a renal-gut countercurrent flow in fruit flies that enhances gut immune response by promoting ROS accumulation and peristalsis through bacterial tyramine recognition.

This study shows that transposable elements (TEs) are involved in a dual response to Drosophila C Virus infection, where TE control is released and TE transcripts help reduce viral replication.

This study shows that parental infection with Pseudomonas entomophila leads to persistent infection in offspring, reduced pathogen virulence, and altered host physiology across generations.

This study uses proteomics to compare C. elegans responses to two protective Pseudomonas symbionts, identifying distinct host pathways involved in pathogen resistance and tolerance.

This study overexpresses REL2 in Anopheles gambiae midgut and finds it causes transcriptional changes but does not induce a strong immune response against Plasmodium falciparum.

The paper shows PAR-5 mediates host-pathogen co-evolution in C. elegans by enhancing embryo development and reducing pathogen virulence, while pathogens exploit PAR-5 to evade immunity.