Cerebrospinal fluid and hydrocephalus

This study shows that enhancing extracranial lymphatic outflow in an Alzheimer's disease rat model reduces amyloid-beta burden and improves neurovascular function through a choroid plexus signaling axis.

This study uses MRI to show neural activity drives directional CSF flow in the subarachnoid space near activated brain regions in awake humans.

This study shows that hypercapnia temporarily increases brain-to-blood protein clearance in TBI and healthy individuals, with effects moderated by brain atrophy.

This study introduces SOPHI, a method to map ultra-slow CSF flow in the human brain, revealing coherent flow patterns linked to vascular anatomy and potential CSF efflux pathways.

The paper identifies genetic associations with perivascular space morphology in children using MRI and genomics data from the Adolescent Brain Cognitive Development Study.

The paper presents a patient-specific simulation framework for intracranial pressure dynamics validated against clinical infusion tests, showing strong agreement with measurements.

This study finds that hypertension is associated with reduced radiotracer removal from lateral ventricles, indicating impaired brain clearance.

The paper reinterprets a CWH43 truncation variant in iNPH using structural analysis, showing it disrupts a conserved C-terminal module and cavity architecture.

This paper introduces an ultra-high-resolution MRI framework to map perivascular spaces (PVS) across the whole brain, revealing their hierarchical organization along vascular trees.

This study shows brain motion in mice is driven by abdominal muscle contractions and linked to hydraulic fluid flow, impacting brain health through mechanical coupling with the abdomen.

The paper proposes a mechanical framework explaining why slow-wave sleep enhances cerebrospinal fluid clearance by aligning vascular dynamics with the brain's low-pass filter properties.

The paper identifies chemoreceptors in cerebrospinal fluid-contacting neurons and neighboring cells, revealing multiple chemosensory pathways for detecting glutamate, somatostatin, and LDL in the cerebrospinal fluid.

This paper develops a low-intensity focused ultrasound (LIFU) strategy to enhance meningeal lymphatic drainage, preventing cognitive decline in Alzheimer's disease models.

This study examines age- and sex-related changes in glymphatic function and meningeal lymphatic vessels (mLVs) and their association with processing speed in humans.

This study uses MRI to show glymphatic fluid movement in live human cortex, finding reduced exchange in Alzheimer's disease.

This study examines how aging and Klotho deletion affect choroid plexus structure and function, finding that Klotho deficiency increases age-related calcification in specific regions.

The paper develops a high-fidelity computational model of astrocyte endfeet and perivascular spaces to study fluid dynamics and mechanical interactions in response to vascular pulsations.

The paper characterizes the evolutionary origin and expression of MAEL in the developing human brain and finds reduced MAEL expression in hydrocephalus brain tissue.

This study maps AQP4 expression across the human brain, linking it to vascular physiology, neurodegenerative disease patterns, and edema, revealing its role in glymphatic function and disease vulnerability.

This study investigates how baseline CO2 levels modulate neurofluid dynamics in awake humans, showing that autonomic nervous system regulation affects flow through frequency changes rather than amplitude.

This study predicts tracer distribution in the brain using geometric MRI data, showing strong correlation with actual tracer enrichment in patients with similar diagnoses.

The paper uses D2O-MRI to show that the lateral ventricles are not the main source of CSF, with higher production observed in the ambient and supracerebellar cisterns.

This study examines how infusion location, rate, and anesthesia affect CSF tracer dynamics in mice using Gd-DTPA and MRI.

The paper discovers abundant nanoscale lymphatic-like vessels in brain parenchyma of mice and humans, suggesting a previously unrecognized system for metabolic waste clearance.

This paper develops an in vitro model of the human CNS to study intrathecal drug dispersion and pharmacokinetics, providing reliable data for therapy design.

This study shows that meningeal scavenger cells clear brain waste more efficiently during wakefulness, regulated by both circadian rhythms and brain state.

This study creates a multi-modal atlas of choroid plexus pathology across aging and Alzheimer's disease, identifying fibrosis, calcification, and macrophage abnormalities as key features.

This study investigates the biomechanics of yawning, showing it alters cranio-cervical fluid dynamics and has reproducible kinematics, suggesting it is a distinct cardiorespiratory maneuver.

This study examines how biological sex and BMI affect the longitudinal changes in MRI-visible perivascular spaces (MV-PVS) in adolescents and young adults.