Exercise and Physiological Responses

This study develops a mouse model of exercise-induced whole body hyperthermia that mimics skeletal muscle injury features observed in heat stress.

This study investigates how erythrocyte extravasation contributes to skeletal muscle injury via the heme-HO-1-iron axis, linking it to ferroptosis and inflammation.

This study shows that cardiorespiratory fitness and sex influence how exercise serum affects colorectal cancer cell viability.

The paper presents initial findings from the MoTrPAC consortium, showing that acute and chronic exercise induce distinct physiological and molecular responses, with chronic training improving key health metrics.

The paper analyzes multi-omic, multi-tissue molecular responses to acute exercise in sedentary adults, identifying key pathways and exerkines involved in exercise effects.

The paper identifies shared and distinct biochemical responses to different exercise modes through plasma proteomics, metabolomics, and transcriptomics in sedentary humans.

This study identifies proteome-wide changes in human tear fluid after acute exercise, revealing upregulated translation-related proteins and downregulated glycan metabolism proteins.

This study shows that Gene III(R) EGT improves exercise performance and reduces fatigue in mice by lowering oxidative stress, inflammation, and activating the AMPK/PGC-1α pathway.

This study assesses if bioimpedance spectroscopy can detect eccentric exercise-induced muscle damage and correlate with functional and mechanical impairments.

This study analyzes public data to assess N-acetylcysteine's protective effects against heat stress in skeletal muscle cells, finding partial protection at 2.0 mM with a large effect size.

This study identifies molecular and cellular signatures of regular physical activity in human peripheral blood using multi-omics profiling, revealing enhanced metabolic and immune functions.

This study uses multi-platform plasma proteomics to identify metabolic signatures distinguishing elite athletes' acute and chronic exercise adaptations.

The paper analyzes skeletal muscle transcriptomic responses to exercise in humans, mice, and rats to identify conserved and species-specific exerkine regulation patterns.

This study investigates quercetin's effects on oxidative stress and DNA damage responses in healthy men during exercise, showing increased nuclear localization and gene expression related to DNA repair and antioxidant pathways.

This study examines how different exercise intensities affect the human plasma secretome and interorgan communication through multi-cohort interventions and multi-organ gene expression analysis.

This study compares targeted and untargeted salivary biomarkers for classifying acute physical fatigue, finding that combining both improves classification accuracy.

This study maps the proteomic changes in plasma, saliva, and urine after acute exercise, identifying over 3,000 regulated proteins and their associations with disease and drug targets.

This study examines how endurance exercise affects liver metabolism in male and female rats over time, revealing sex-specific molecular changes and protective effects.

This study shows that consuming glucosinolate-rich red kale sprouts reduces blood lactate during submaximal cycling and increases resting blood glucose.

This study shows exercise induces anti-inflammatory reprogramming in macrophages via Hsp60, identified through secretome analysis and proteomic profiling.

The paper analyzes exerkine responsiveness in exercised rodents using multi-omics data to identify tissue-specific and sex-dimorphic responses.

This study shows that Ultra-small Particle Size Nanobubbles Water improves antioxidant activity and physical performance in chronically fatigued rats.

This study compares the effects of moderate and vigorous exercise on intestinal damage, stress response, inflammation, and gut microbiota in mice, finding that daily moderate exercise causes more severe injury than vigorous training with rest days.

This study found no effect of menstrual cycle phase or oral contraceptive use on neuromuscular impairments after eccentric exercise or the repeated bout effect.

This study examines the temporal recovery of torque in contralateral and ipsilateral knee extensors after unilateral resistance exercise in trained men, finding reduced torque in both but more pronounced effects in the ipsilateral limb.

This study maps the organism-wide secretome response to exercise in mice, identifying 200+ exercise-regulated protein pairs and uncovering anti-obesity and anti-diabetic roles of a liver-secreted proteoform.

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.

The paper compares transcriptomic responses in skeletal muscle and extracellular vesicles after traditional and high-intensity exercise in young adults, finding more consistent gene responses to traditional exercise and unique microRNA responses to high-intensity training.

The paper shows that plasma from exercising mice reduces brain inflammation and improves memory, with clusterin as a key anti-inflammatory factor also elevated in human exercisers.