interferon and immune responses

The paper identifies HELZ2 as an ISG protein that inhibits LINE-1 retrotransposition and reduces IFN- induction by interacting with L1 RNA and ORF1p.

This study shows that constitutively active STING in mice leads to neuroinflammation and dopaminergic neuron degeneration, suggesting therapeutic targeting of this pathway.

This study shows that c-Src phosphorylates cGAS, reducing its DNA binding and activation, thereby inhibiting anti-tumor immune responses in cancer.

This study investigates TE activation in SARS-CoV-2 infection, finding it induces a weaker IFN response compared to other viruses, with TE expression and viral load explaining immune response diversity.

The paper identifies a Neandertal introgressed haplotype in the OAS1 gene associated with increased risk of severe COVID-19 and shows it impairs SARS-CoV-2 clearance through genetic regulation of OAS1 expression.

This study identifies how cGAS-STING regulates autophagy through multiple pathways, including mTOR inhibition, autophagy-related protein regulation, and interactions with Bcl2 and USP19.

The paper identifies small cytosolic DNAs (scDNAs) that inhibit cGAS activation and induce autophagy, preventing excessive inflammation.

This study shows that Ifit2 deficiency in mice leads to severe viral spread and demyelination in the spinal cord during chronic RSA59 infection.

This study identifies IFN pathway lupus risk alleles associated with COVID-19 mortality and develops predictive models combining genetics and biomarkers.

This study shows ISG15 monomer enhances IFNα antiviral activity against PRV by promoting STAT1/STAT2 phosphorylation and reducing viral replication.

The paper develops a high-content assay to identify viral genes that suppress innate immunity and validates known and novel immune suppressors from various viral families.

This study shows that PALA enhances antiviral responses by activating non-canonical NOD2 signaling, improving type I interferon production and ISG expression.

The paper investigates the role of RIG1, MDA5, and INFalpha in duck plague infection using in silico and experimental methods to understand host innate immunity.

The paper identifies a two-factor authentication mechanism used by the innate immune system to detect low-abundance HIV-1 DNA through PQBP1-mediated capsid recognition and cGAS recruitment.

The paper identifies LY6S, a new human interferon-inducible gene associated with inflammation and viral resistance, and describes its expression and functional effects.

The paper investigates monocyte subset heterogeneity and its impact on influenza virus susceptibility across populations, revealing differences in transcriptional responses and infection resistance between African and European ancestry individuals.

The paper develops a spatial multicellular model of RNA virus replication and interferon responses, showing how interferon concentrations and diffusion rates affect plaque growth dynamics.

The paper identifies OLFML3 as a rhinovirus-inducible IFN antagonist using surfaceome CRISPR screening, showing its role in suppressing innate immunity.

This study shows that defective interfering particles (DIPs) primarily exert antiviral activity through interferon (IFN) system activation rather than suppression of viral replication.

The paper shows FTO suppresses proinflammatory ISG expression by inhibiting STAT3 activation during the type I IFN response.

This study shows TRIM25 inhibits Influenza A virus by destabilizing its mRNA and is not required for the RIG-I pathway.

The paper identifies novel antiviral interferon-sensitive genes using correlation-driven gene selection and systems biology approaches in HCV-permissive cells.

This paper shows that the SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling in human cells.

The paper uses single-cell RNA-Seq and imaging to study how intestinal cell types respond to viral infection, finding that each lineage has unique antiviral responses.

The paper investigates how dsRNA length, IFNAR1 expression, and age affect innate immune responses and cognitive impairment in mice using poly I:C.

This study shows that STING modulates nascent DNA degradation at stalled replication forks, linking replication stress to innate immunity.

This study finds that genetic variants affecting IFN-λ4 production are linked to increased risk and earlier occurrence of gastrointestinal, respiratory, and malaria infections in Malian children.

The paper shows that high-dose IFN-β activates both ISGF3 and GAF in epithelial cells, with GAF enhancing ISGF3 target gene expression through co-localization and chromosome looping.

The paper models the complete kinetics of coxsackievirus B3 to identify human determinants of host-cell feedback, revealing that MAVS cleavability influences viral outcomes.

The paper shows that mitochondrial DNA breaks trigger a type I interferon response through nuclear sensing, enhancing immune surveillance against genotoxic stress.