Nuclear Structure and Function

This study identifies chromatin reorganization and histone mark changes in HGPS VSMCs, linking them to vascular pathology through disrupted enhancer-promoter interactions.

The paper identifies a nuclear polarity pathway in Arabidopsis meiosis by showing how telomeres interact with SUN1/2 domains on the nuclear envelope to form a bouquet structure.

The paper shows that in Drosophila spermatocytes, nucleoli convert into NLBs that serve as platforms for RNA Polymerase II transcription of Y-linked fertility genes.

The paper uses super-resolution imaging and in situ sequencing to map RNA distribution within nucleolar subdomains, revealing distinct RNA populations and processing dynamics.

This study shows vimentin enhances nuclear deformation in polarized cells by linking to nesprin-3 and transmitting forces through the nuclear envelope.

This study shows disease-related short tandem repeats relocate to nuclear pore complexes, with implications for genome stability and repeat dynamics.

This study shows that SUN2 in the nucleus regulates endothelial cell-matrix interactions, affecting vascular homeostasis and barrier function through microtubule and matrix metalloprotease mechanisms.

This study investigates nucleolar changes during zebrafish oogenesis and finds similar patterns in mouse oocytes, suggesting conserved nucleolar remodeling for translational adaptation.

This study shows that A-type and B-type lamins have opposing roles in LBR localization and dynamics, with lamin A displacing LBR from the nuclear envelope while lamin B1/B2 tether it.

This study links reduced lamin A/C expression and dimerisation to nuclear deformability in malignant cancer cells, showing greater sensitivity in MDA-MB-231 cells.

This study shows that NPP-3/NUP205 depletion in C. elegans embryos causes chromosomal relocalization to the nuclear periphery, which protects genome stability by reducing DNA damage and micronuclei formation.

The paper investigates how lamina-associated domains (LADs) act as size-selective steric barriers to limit protein access to the nuclear periphery, providing a biophysical mechanism for gene regulation.

The paper uses sequence and structural alignments to study ANKLE2 evolution and function, revealing conserved domains and potential roles in DNA damage response.

This study identifies CYCLON as a nucleolar protein that regulates cancer cell fitness by controlling ribosome biogenesis and nucleolar structure across multiple tumor types.

This study identifies 79 cargos bound by IPO9, showing it recognizes proteins without cNLSs, and defines structural elements that mediate cargo selection and release.

The paper shows that lamins A and B1 maintain LADs and gene expression in yolk sac endoderm by interacting with transcription factors.

The paper identifies the ETS domain as a structure-encoded NLS recognized by importins, revealing how importins mediate nuclear import of ETS transcription factors.

This study shows that aging podocytes lose nuclear-cytoplasmic compartmentalization, leading to metabolic and transcriptional dysregulation.

The paper identifies Nup133 and Nup107 as regulators of HTCA development and shows that NPCs recruit dynein to the nuclear envelope to facilitate centriole-nuclear attachment during spermiogenesis.

This study quantifies telomere dynamics in HGPS patient fibroblasts and shows that C75 fully restores chromatin dynamics while Lonafarnib only partially rescues them.

The paper shows that nuclear N-glycans modify INM proteins, regulate H3K9me3, and maintain genomic stability by interacting with SETDB1.

This study shows that the SUN1 H118Y variant impairs CUL3 neddylation, leading to insulin resistance, and that inhibiting neddylation can restore insulin signaling.

This study examines the dynamic interactions between nucleoli and centromeres in living cells, showing that centromeres move and associate with nucleoli during interphase, with these interactions dependent on rDNA transcription and nucleolar integrity.

This study investigates how dysregulated Lamin B1 in DYT1 dystonia affects nuclear structure and disrupts 14-3-3 proteins, linking nuclear deformation to neuronal dysfunction.

The paper identifies hnRNPK as a key regulator of LAD positioning and reveals two distinct LAD classes based on epigenetic marks.

This study shows that perinuclear telomere anchoring via Lem2 is essential for Ustilago maydis to infect plants, as its deletion disrupts nuclear migration and leads to infection failure.

This study shows that nuclear rupture in LMNA-DCM leads to transcriptional deficiency and identifies resealing as a protective mechanism that is ultimately insufficient.

The paper uses super-resolution microscopy to analyze NPC distribution on the nuclear envelope, finding repulsion lengths, actin, heterochromatin, and curvature correlations.

This study identifies 28S rRNA as a key organizer of the tripartite nucleolus structure through multivalent interactions that drive the formation of the three-layered architecture.