Nuclear Structure and Function

The paper shows that phagosome-induced nuclear deformation in Drosophila macrophages increases Lamin B levels, enhancing phagocytic capacity.

This study identifies two independent binding sites on lamin A/C that anchor emerin at the inner nuclear membrane, revealing a revised model for emerin retention.

The paper shows ERM proteins link actin filaments to the nuclear envelope by forming a perinuclear actin rim in melanoma cells.

This study shows that the nucleus softens during herpesvirus infection due to reduced outward forces and low biomolecular density in the viral replication compartment.

This study shows that nuclear and actin mechanics change from G1 to G2, leading to decreased nuclear stiffness and increased vulnerability to rupture.

This study investigates TCS4-associated mutations in S. pombe by analyzing their effects on rRNA transcription and cell growth.

This study examines how nuclear pore complex structure and function change under different cellular stresses in HL-60/S4 cells using GSEA.

This study shows lamin A/C maintains genome structure and transcriptional programs needed for EBV-driven B cell activation, with loss causing chromatin reorganization and gene expression changes.

The paper uses Alphafold3 to predict and validate the structure of the Imp{beta}/Imp7/H1 complex, showing H1 binds to Imp7 rather than Imp{beta} and identifying key interaction regions.

This study shows that MLP1, a nuclear pore complex protein in Trypanosoma brucei, is essential for nuclear integrity, mRNA export, and genome stability by maintaining proper chromosome segregation and ploidy.

The paper shows camptothecin suppresses nuclear blebbing by stalling RNA Pol II and increasing chromatin stiffness.

This study identifies RCC1 depletion as a cause of protein transport defects and micronuclei rupture, linking it to nuclear lamina defects and genome instability.

This study identifies primary target pathways of progerin in HGPS patients through transcriptomic analysis, revealing mTORC1, UPR, UV response, apoptosis, and TNF signaling as key affected pathways.

This study shows that nucleolar reorganization under stress is driven by changes in nascent rRNA synthesis, not signaling pathways.

This paper challenges the established model of actin import by showing IPO9 directly binds monomeric actin and competes with cofilin and profilin for actin binding.

This study identifies ZNF16 as a nucleolar protein that regulates rDNA transcription and cancer-related genes, showing its role in cell viability and multiple biological pathways.

The paper models nuclear chromatin compartmentalization using crosslinking, contractile motors, and deformable lamina, showing how these factors drive genomic segregation and heterochromatin formation.

This study presents a modeling framework simulating nuclear transport at full amino-acid resolution, revealing the dynamic FG-meshwork and role of Nsp1 and NTRs in transport.

The paper shows FG-NUPs in live cells exhibit liquid-like mobility, while in vitro they transition to solid, with O-GlcNAcylation and importin-β maintaining the dynamic FG network's liquidity.

This study shows paclitaxel causes nuclear damage in interphase via SUN2-mediated Lamin A/C disruption, revealing an additional mechanism beyond its known mitotic effects.

The paper shows reduced ZMPSTE24 leads to prelamin accumulation and steatosis in MASLD patients, linking it to p53 activation and metabolic dysfunction.

This study shows that nuclear envelope integrity maintains epigenetic stability in Arabidopsis by coupling chromatin organization to epigenomic drift during aging.

This study identifies CLCC1 as a Torsin1A binding partner essential for nuclear envelope membrane fusion during NPC biogenesis, showing its therapeutic potential for DYT1 dystonia.

This study shows that nuclear basket displacement in aging yeast causes chromosome loss by disrupting pre-mRNA quality control and asymmetric segregation.

The paper identifies a classical NLS in Black Sea Bass Polyomavirus LTA that mediates nuclear import via Importin α/β1, distinct from mammalian PyVs.

This study shows that importin-7 facilitates HPV transport from the Golgi to the nucleus, promoting infection by binding to the HPV capsid protein L2.

This study shows that separase interacts with nuclear lamins in Drosophila and humans, affecting nuclear organization and lamin levels, indicating an evolutionarily conserved role.

This study shows that impaired 5'ETS pre-rRNA cleavage disrupts nucleolar organization, leading to mislocalization of RNA and proteins, and broader nuclear architecture changes.

The paper constructs an integrative Brownian dynamics model of nucleocytoplasmic transport, revealing how FG repeat proteins and nuclear transport receptors mediate selective transport through NPCs.

This study shows that microtubule forces, not the LINC complex, drive nuclear damage in LMNA cardiomyopathy and that disrupting microtubules can rescue cardiac function.