Nuclear Structure and Function

The paper reports the crystal structure of the SUN1-KASH6 complex, revealing an asymmetric arrangement that explains how KASH proteins can insert into the outer nuclear membrane.

The paper investigates the physical mechanisms of nucleolus disassembly during mitosis, identifying two distinct phases and proposing a universal design principle for biomolecular condensate disassembly.

This study uses simulations to show that HIV-1 capsid shape, orientation, and elasticity are critical for translocation through the nuclear pore complex.

This paper develops a FRET-based biosensor to visualize lamin A phosphorylation at Serine 22 in live cells, revealing its dynamics during the cell cycle and its role in nuclear envelope breakdown.

The paper identifies Crm1 as an adaptor that links transcription factors to chromatin at the nuclear pore complex, facilitating enhancer docking.

This study identifies NOC1 as a direct MYC target and shows its role in nucleolar function through protein interactions and structural changes.

The paper shows that Nup98 nucleoporins use phase separation to mobilize heterochromatic repair sites and exclude Rad51, promoting homologous recombination and genome integrity.

This study identifies PP2A-B55SUR-6 as a phosphatase promoting nuclear envelope breakdown in C. elegans embryos by dephosphorylating lamina and nucleoporins, working with microtubule forces.

The paper shows that SMN shuttles from Cajal bodies to the nucleolus during DNA repair, aiding in nucleolar structure restoration after genotoxic stress.

This study identifies a conserved NES in Pch2 required for its nuclear export and checkpoint activity during meiosis.

This study expresses Dictyostelium lamin-like protein NE81 in mammalian cells to show conserved mechanoprotective roles of lamins in nuclear morphology and stability.

The paper shows nuclear growth and import can be uncoupled, suggesting chromatin mechanical properties drive nuclear growth rather than import alone.

This study shows ghrelin improves cellular and organismal features of HGPS by promoting autophagy and clearing progerin, extending lifespan in a mouse model.

The paper investigates NE hole closure during meiosis II in C. elegans oocytes, showing distinct roles for BAF-LEM and LEM-2-CHMP-7 in sealing NE holes around spindle MTs.

The paper identifies conserved protein motifs in KAKU4 and related nucleoporins that mediate nucleoskeleton attachment to nuclear pores in plants.

This paper creates C. elegans models for striated muscle laminopathies by introducing human LMNA variants, finding that variants affecting both skeletal and cardiac muscle cause more severe phenotypes.

The paper shows that the plant nuclear lamina disassembles under stress, altering chromatin organization and transcriptional profiles.

The paper identifies importins that bind nascent proteins co-translationally in yeast, showing their role in preventing aggregation and integrating with ribosome-associated chaperones.

The paper examines how nuclear lamina association and genome compartmentalization influence gene regulation across different cell types and treatments.

This study shows that lysolipid treatment alters NE lipid composition, reducing Sir4 telomere association and triggering lipid-specific transcriptional changes in yeast.

This study identifies lamin A/C phosphorylation at Ser22 as a conserved heat shock response that regulates nuclear structure and cell survival during stress.

The paper maps lamin-associated chromatin across twelve human cell types, identifying two subtypes with distinct features and developmental dynamics.

This study uses a coarse-grained model to show that FG-Nup hydrophobicity determines NPC selectivity and specificity in transport.

This study identifies transcriptional deficits in HGPS fibroblasts related to mesenchymal differentiation and endochondral ossification, with age-dependent gene expression changes.

The paper measures nuclear transport rates in single yeast cells using FRAP and identifies variability in nuclear pore complexes and other factors as sources of cell-to-cell differences.

The paper shows that nucleoporins, specifically Elys, are required for ORC2 loading onto chromatin and proper replication initiation in Drosophila.

This study identifies DNAJB6 as a molecular chaperone that prevents FG-Nup aggregation during interphase nuclear pore complex biogenesis.

The paper identifies that differential nuclear import timing controls gene expression onset in early embryonic development by regulating protein access to the genome.

This study determines the structure of Importin-4 bound to the H3-H4·ASF1 complex, revealing how Importin-4 recognizes and transports the histone chaperone complex into the nucleus.