Barrier Structure and Function Studies

The paper maps the spatial relationship between cerebrovasculature, pericytes, and neuronal cell types in mice to reveal how they support regional brain energy homeostasis.

This study demonstrates that focused ultrasound with microbubbles enhances the delivery of Aducanumab and anti-Tau antibodies across a human sporadic Alzheimer's disease blood-brain barrier model.

This study investigates how the carboxyl terminal domain of Cx43 affects astrocyte endfoot organization and BBB permeability in mice.

The paper uses in vivo two-photon imaging to distinguish perivascular fibroblasts from mural cells in mouse cerebral cortex, revealing unique structural and distributional features.

The paper compares brain delivery and efficacy of two TfR-targeted enzyme fusions in MPS II mice, finding the moderate-affinity ETV:IDS has better brain exposure and substrate reduction than the high-affinity IgG:IDS.

This study shows that TMAO enhances BBB integrity and protects against inflammation, while TMA impairs BBB function and cognitive resilience in mice.

This study shows ibuprofen reduces inflammation and restores neurovascular unit integrity in growth-restricted newborn piglets.

This study shows that activating Wnt signaling in human pluripotent stem cell-derived naive endothelial progenitors promotes the acquisition of blood-brain barrier properties.

This study shows that high-sucrose diets in Glo1-deficient mice cause brain angiopathy, impaired glucose uptake, and psychosis-related behaviors, with aspirin offering protection.

The paper identifies a conserved pericyte gene signature in zebrafish using scRNA-seq and validates it with transgenic reporter lines.

This study shows that MLC1 is essential for postnatal development of the gliovascular unit, leading to vascular and fluid clearance defects in a mouse model of megalencephalic leukoencephalopathy.

This study shows that different basal media compositions significantly affect BBB properties in human iPSC-derived BMEC-like cells, influencing passive and active transport and signaling pathways.

This paper describes a method to image and analyze 3D vascular networks in mouse brains across development and adulthood, quantifying various vascular features.

This study identifies PKA as a key effector of the Moody GPCR in Drosophila BBB formation and maintenance, showing its role in regulating cell growth and junction integrity.

This study shows that autocrine bFGF is essential for BCEC barrier function, while exogenous bFGF inhibits barrier resistance in a concentration-dependent manner.

This study shows that microvascular injury from mild TBI accelerates Alzheimer-like pathology in mice, suggesting vascular repair could mitigate AD risk.

The paper shows that transient opening of tricellular vertices in Drosophila follicle epithelium allows paracellular transport of yolk proteins during oogenesis, regulated by adhesion and actomyosin dynamics.

The paper compares in vitro blood-brain barrier models from mice, rats, and pigs to identify species-dependent differences in barrier characteristics and TEER.

This study identifies AMPK as a key regulator of retinal vascular permeability by linking Ca2+ signals to eNOS and p38 activation, using an ex-vivo retina model.

This study shows that the blood brain barrier in 22q11.2 deletion syndrome is compromised, leading to increased neuroinflammation and potential risk for neuropsychiatric disorders.

This study shows that pericytes restrict immune cell entry into the CNS by maintaining immune quiescence of brain endothelial cells, and their deficiency leads to increased leukocyte infiltration and severe neuroinflammation.

The paper identifies cardiac glycosides as regulators of neuroinflammatory pathways in brain-barrier tissues using in vitro and ex vivo human models.

This study shows capillary pericytes influence blood flow but with slower kinetics than upstream cells, and their removal increases blood flow.

This study shows that loud rock music can temporarily open the blood-brain barrier in healthy mice without causing cochlear or brain damage.

This study shows that BBB disruption triggers a secondary barrier at the Glia Limitans via astrocytic response, reducing disease severity in multiple sclerosis.

This study investigates how LRP1 mediates transport across blood-brain barrier endothelial cells, showing that ligand avidity influences cargo sorting and trafficking mechanisms.

This study investigates how SARS-CoV-2 spike protein affects the blood-brain barrier using in vitro models, showing barrier disruption and pro-inflammatory responses in human brain endothelial cells.

This study shows that mature astrocytes are necessary for maintaining blood-brain barrier integrity in adult mice, as their ablation leads to BBB damage and persistent leakage.

This study identifies zonation-dependent transcriptomic changes in aged brain endothelial cells, highlighting functional impacts on the BBB and AD-associated genes, and shows reversal with GLP-1R agonist treatment.