Hedgehog Signaling Pathway Studies

The paper identifies PCYT2, ETNK1, and the phosphatidylethanolamine biosynthetic pathway as genetic suppressors of drug resistance in Gorlin syndrome tumors through basal to squamous cell carcinoma transition.

This study shows that deleting Gpr161 in the Pax3 lineage in mice causes spinal and craniofacial defects due to altered Shh and Wnt signaling.

The paper shows SMARCC1 does not mediate GLI3 repression of Hedgehog target genes, as it maintains chromatin accessibility at GLI-regulated enhancers independently of GLI3.

This study identifies Ulk4's role in promoting Shh signaling by regulating Stk36 localization and Gli2 phosphorylation at the ciliary tip.

This study identifies DHH as a key ligand in the Hedgehog signaling pathway that regulates fibro/adipogenic progenitor fate during skeletal muscle regeneration, preventing adipogenesis and promoting fibrosis.

This study shows that Sonic hedgehog (SHH) signaling is critical for maintaining epithelial integrity in the larynx and anterior foregut, with SHH loss causing abnormal epithelial to mesenchymal transition and replacement by Pax-1 expressing cells.

This study shows Lhx2 modulates Sonic Hedgehog signaling in retinal progenitors through direct and indirect regulation of pathway components, establishing competence for signaling during early neurogenesis.

The paper studies how movement of the Hh morphogen source affects signaling dynamics in Drosophila organs, showing spatial and temporal differences in Ptc and CiA distribution.

This study identifies Plexins as novel components of the Hedgehog pathway, showing they promote signaling through their GAP activity and primary cilia interaction.

The paper shows Hedgehog signaling enhances glycolytic ATP production in Drosophila wing disc tissue, revealing a feedback loop between signaling and energy metabolism.

The paper investigates SUFU's role in regulating Hedgehog signaling during astrocyte differentiation in P19 cells, finding that SUFU is necessary for proper timing and proportion of astrocyte differentiation.

This study identifies Hedgehog signaling as a regulator of differentiation timing through a heterochronic gene regulatory network in cardiac and neural lineages.

The paper shows that high Hedgehog signaling controls Smoothened's apico-basal distribution through a multikinase-dependent switch involving Protein Kinase A, Casein Kinase I, and Fused kinase.

This study shows Sonic Hedgehog (Shh) acts as a trigger for digit specification through a relay network rather than as a traditional morphogen.

This study shows that Sonic hedgehog signaling is critical for limb development in axolotls, with loss of Shh leading to complete absence of forelimbs and highlighting a derived mode of limb development in urodeles.

The paper shows GLI3 repression does not prevent precocious activation of HH target genes or regulate anterior-posterior limb polarity.

This study identifies an autocrine role for Hedgehog signaling in regulating epithelial cell proliferation and differentiation in the trachea.

This study identifies Gli1's role in regulating endoneurial architecture in peripheral nerves, showing it functions independently of Dhh and is required for maintaining nerve structure.

The paper shows that ciliary Hedgehog signaling is essential for cell survival in the facial midline, and its disruption causes craniofacial defects in mouse models of ciliopathies.

This study shows that THC inhibits Hedgehog signaling in embryos, causing developmental defects, and acts as a conditional teratogen when combined with genetic risk factors.

The paper shows that gene-teratogen interactions affect birth defect penetrance by altering Hedgehog signaling through the MMM complex and SMO degradation.

This study shows hedgehog pathway genes are expressed in adult mouse hypothalamic neurons involved in feeding and that pathway activity is transcriptionally regulated by fasting.

The paper compares the spatial expression of Sonic Hedgehog and pathway components in the embryonic mouse head to understand context-dependent feedback regulation.

The paper shows that the extent of Hh, Wg, and Dpp signaling is independent of signal production levels or recipient cell numbers.

This study shows Rab23 represses basal Shh signaling and facilitates Shh/Smo signal transduction via primary cilia in GCPs, with implications for medulloblastoma therapy.

This study identifies FGF5 signaling as a key driver in SHH subgroup infantile medulloblastoma, showing its upregulation and therapeutic potential through FGFR inhibition.

This study identifies a mutation in the boc gene that disrupts oligodendrocyte formation in zebrafish by affecting Shh signaling maintenance in pMN progenitors.

The paper investigates how Shh signaling and basal epidermal collective migration drive skeletal branching in zebrafish fins during development.

The paper shows taste bud cell renewal begins at birth and SHH signaling shifts from repressing to promoting taste cell differentiation.

The paper shows that Ihog's dual roles in homophilic adhesion and Hh signaling are functionally coordinated to facilitate Hh transport and reception along cytonemes.