Hippo pathway signaling and YAP/TAZ

This study investigates the role of YAP1 and TAZ in pancreatic inflammation and evaluates the therapeutic potential of VT-104 in a mouse model of pancreatitis.

This study identifies disrupting YAP-B-MYB interaction and targeting NEK2 as potential therapies for YAP-driven cancers, showing reduced tumorigenesis and cell cycle defects.

The paper shows that aggressive high-grade NF2 mutant meningiomas have reduced YAP1 activity due to increased VGLL4 and FAT3/4 expression, linked to higher recurrence risk.

The paper identifies basal spot junctions in Drosophila epithelial tissues that respond to mechanical forces and regulate Hippo signaling by sequestering Warts kinase.

This study investigates how ECM stiffening affects YAP mechanosignaling in SC cells and shows that disrupting YAP signaling improves outflow facility in glaucoma.

The paper shows that Ds-Fat signaling regulates cell cycle duration scaling with wing size, affecting wing growth rate in Drosophila.

This study identifies RasGAP and ZO-2 as essential for p190A RhoGAP's tumor suppressor function and Hippo signaling activation.

The paper shows that YAP-1 coordinates organ growth with body size in C. elegans to maintain uniform proportions, even under tissue-specific growth inhibition.

This study shows cortical tension modulates Hippo signaling by affecting Kibra degradation through Par-1.

The paper shows that inactivating RB and Hippo pathways in Drosophila photoreceptors causes dedifferentiation by derepressing homothorax, revealing their cooperative role in maintaining neuronal identity.

This study shows apical polarity and actomyosin dynamics control Kibra localization, which regulates Hippo signaling and tissue growth.

This study shows that Yap/Taz in AT2 cells are essential for alveolar regeneration and preventing fibrosis after lung injury.

This study investigates the function of Hippo pathway kinases in the unicellular organism Capsaspora, revealing their role in regulating cell density and contractile behavior through cytoskeletal changes.

This study identifies LSR as a negative regulator of YAP activity, essential for Paneth cell differentiation and a potential therapeutic target for inflammatory bowel disease.

This study shows YAP/TAZ promote P-body formation in cancer cells, enhancing tumorigenesis, and suggests targeting P-bodies or PNRC1 could be therapeutic.

The paper identifies SM04690, a CLK2 inhibitor, as a YAP activator by promoting alternative splicing of AMOTL2, leading to reduced YAP phosphorylation and membrane localization.

This study shows that downregulating Yap1 in axolotl limb regeneration impairs bone formation, highlighting its role in regeneration through protease inhibition, immune activity, and ECM changes.

This study identifies the Hippo pathway's role in Drosophila eye development through the interaction of Yorkie and Bonus, showing they control cell fate by promoting epidermal and antennal fates over eye fate.

This study shows that oncogenic YAP alters chromatin accessibility and activity, driving cell cycle gene expression and migration through enhancer-mediated mechanisms.

The paper uses PDE modeling and image analysis to show that nuclear phosphorylation and AKT interaction regulate YAP and TAZ shuttling dynamics in response to APAP-induced liver injury.

This study shows Yap regulates DNA replication dynamics and interacts with Rif1 to control replication timing in early embryos and stem cells.

The paper shows that DNA damage induces apoptosis in zebrafish yap1-/-;wwtr1-/- epidermal basal cells, with substrate stiffness modulating genomic stress and cell survival.

This study investigates YAP's role in early ectodermal specification and its link to Huntington's Disease using human neuruloids, finding YAP activation influences ectodermal fate and that reducing YAP activity can partially rescue HD phenotypes.

The paper shows that YAP activation in Procr+ ovarian progenitors is essential for OSE repair and stem/progenitor expansion through reduced Vgll4 expression and increased Procr transcription.

This study develops a YAP fusion reporter mouse line and uses live imaging to analyze YAP localization dynamics during mouse embryonic development.

This study identifies YAP and TAZ as transcriptional co-activators of AP-1 and STAT3 in breast cancer, showing their role in gene regulation and poor patient survival.

This study shows YAP/TAZ are essential for maintaining radial glial cell function during brain development, affecting neuronal and ependymal cell numbers and causing hydrocephaly when disrupted.

This study identifies Crumbs and the apical spectrin cytoskeleton as regulators of R8 cell fate in Drosophila eye, distinct from their role in Hippo-dependent organ growth.

The paper identifies a small-molecule inhibitor of Lats kinases that promotes Yap-dependent proliferation in postmitotic mammalian tissues, enabling hair cell regeneration in the inner ear.