Fibroblast Growth Factor Research

The paper shows that GRB2 binding to the C-terminal of FGFR2, independent of FRS2, is not essential for embryonic development or adult homeostasis.

The paper quantifies kinase activity dynamics in response to FGF ligands and uses dynamic modeling to reveal pathway regulation and novel kinase involvement.

This study shows that FGF signaling regulates salivary gland branching by modulating cell adhesion, with non-canonical mechanisms involved.

The paper shows that Wengen, a TNFR, regulates the FGFR pathway by an unconventional mechanism involving intracellular trafficking and interaction with Breathless.

The paper finds that male and female mice show similar protein preference and plasma FGF21 responses to dietary protein restriction, with no effect of estrous cycle stage on preference or FGF21 levels during restriction.

This study shows FGF21 reduces ethanol-induced intoxication by activating noradrenergic neurons, improving recovery from ethanol exposure in mice.

The paper shows GPI-anchored FGF directs bidirectional cytoneme-mediated signaling between cells to regulate tissue-specific dispersion and signaling.

This study shows that FGF21-FGFR4 signaling in cardiac myocytes causes concentric hypertrophy in diabetic mice, suggesting it may contribute to HFpEF and that FGFR4 blockade could be a therapeutic target.

The paper quantifies FGFR3 signaling in live cells using micropatterned surfaces and GRB2 recruitment, showing ligand-dependent and mutant-specific activation patterns.

The paper shows that inhibiting bromodomain proteins like BRD4 reduces FGF15/19 expression, leading to hyperglycemia, and that overexpressing FGF19 can reverse these effects.

The paper develops a computational model of FGFR4 signalling to identify cell type-selective combination therapies for FGFR4-driven cancers, revealing AKT and ERK reactivation as key resistance mechanisms.

This study shows that mice with high FGF21 levels have reduced morphine preference and less acute opioid tolerance and dependence.

The paper describes the development and validation of a new Fgf10CreERT2 mouse line (Fgf10Ki-v2) that effectively targets Fgf10-positive cells in adult lungs, overcoming limitations of an earlier version.

This study shows that sustained hypothalamic MAPK/ERK signaling is essential for FGF1-induced diabetes remission in rodents.

This study investigates FGF signaling beyond canonical pathways by analyzing Fgfr1 and Fgfr2 mutations in mice, revealing novel kinase-dependent cell adhesion properties independent of traditional signaling cascades.

The paper investigates how FGF signaling dynamics influence epithelial morphogenesis by analyzing mammary organoids and using mathematical modeling.

This study shows FGF9 and FGF10 use distinct FGFRs and signaling pathways to regulate lung epithelial development and branching.

This study shows that FGF21 suppresses fructose preference in mice but not glucose or sucrose, and this effect requires central β-klotho expression.

This study identifies FGF signaling's role in mammary fibroblasts, showing it regulates proliferation, migration, ECM production/remodeling, and epithelial branching.

The paper analyzes fibroblast growth factor receptor mutants in zebrafish, revealing functional redundancy that ensures robustness in developmental signaling.

A common FGF21 allele is associated with lower body fat in the lower body, higher blood pressure, and increased carbohydrate intake in a large human cohort.