Fibroblast Growth Factor Research

Proteomic profiling of experimental acute alcohol intoxication reveals FGF21 as a specific ethanol-induced hormone

This study identifies FGF21 as a specific ethanol-induced hormone through proteomic profiling of acute alcohol intoxication in humans.

TMPRSS6 Cleavage of β-Klotho Modulates FGF19 Signaling

The paper identifies β-Klotho as a novel substrate of TMPRSS6, showing that TMPRSS6 cleavage reduces KLB surface abundance and attenuates FGF19 signaling, linking TMPRSS6 to hepatic lipid metabolism.

A hypothalamus-liver-skeletal muscle axis controlled by JNK1 and FGF21 mediates olanzapine-induced insulin resistance in an intraperitoneal treatment in male mice

This study shows that intraperitoneal olanzapine treatment in male mice causes insulin resistance via a hypothalamus-liver-skeletal muscle axis involving JNK1 and FGF21, with PTP1B deficiency offering protection.

Fibroblast growth factor receptor substrate 2 interactome mapping reveals novel candidate interactors associated with migration and invasion

This study maps the FRS2 interactome in medulloblastoma cells, identifying novel proteins involved in cell migration and invasion, and highlights FRS2's role in tumor aggressiveness.

Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α

This study shows that palmitoylation of FRS2α is essential for FGF1-induced signaling and cellular responses, including MAPK activation and neuronal differentiation.

An FGF7-FGFR2-KLF4 feedback loop sustains anti-inflammatory signaling in epithelial cells

This study identifies an FGF7-FGFR2-KLF4 feedback loop that maintains anti-inflammatory signaling in epithelial cells, offering potential therapeutic strategies for inflammatory diseases.

CNOT6 deadenylase safeguards postnatal growth and metabolic transition via Fgf21 mRNA decay

This study identifies CNOT6 as a critical regulator of neonatal growth and metabolism by controlling Fgf21 mRNA decay, revealing its role in metabolic transition and postnatal development.

Api5-FGF2 regulates the transformation of breast epithelial cells via PDK1/Akt and Ras/MAPK/ERK signalling

This study shows that Api5 overexpression increases FGF2 levels and activates PDK1/Akt and Ras/MAPK/ERK pathways, leading to breast epithelial cell transformation.

The Ets transcription factor ETV4 regulates FGF1-dependent proliferation and glycolysis in ER-positive breast cancer

This study identifies ETV4 as a mediator of FGF1-driven proliferation and glycolysis in ER-positive breast cancer, linking obesity-related FGF1 production to tumor progression.

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency

This study identifies G3P-ChREBP as a mechanism linking Citrin Deficiency to metabolic dysfunction by activating FGF21 and lipogenesis, affecting food and alcohol choices.

Downregulated expression of hepatic β-Klotho is associated with the hypertensive phenotype in SHR

This study finds that hepatic β-Klotho is downregulated in hypertensive SHR, suggesting peripheral FGF-21 resistance links metabolic dysfunction to hypertension.

Hepatocyte FGF21 is not required for fasting-induced metabolic responses but guides protein appetite after energy depletion

Direct cell reprogramming by a designed agonist inducing HER2-FGFR proximity

This paper designs a synthetic ligand, H2F, that induces HER2-FGFR proximity to reprogram fibroblasts into myogenic cells and promote myogenic regeneration.

Discovery and optimization of a guanylhydrazone-based small molecule to replace bFGF for cell culture applications

The paper identifies and optimizes a guanylhydrazone-based small molecule that mimics bFGF's function in cell culture, showing improved potency and thermal stability.

Multiple FGFR1 mutations modulate tumorigenic mechanisms in glioneuronal tumors.

The paper investigates how multiple FGFR1 mutations affect tumorigenic mechanisms in glioneuronal tumors by analyzing their interactomes and functional impacts.

FGF21 Analogue PF-05231023 on Alcohol Consumption and Neuronal Activity in the Nucleus Accumbens

This study evaluates the effects of PF-05231023, an FGF21 analogue, on alcohol consumption and neuronal activity in the nucleus accumbens, showing reduced intake and altered neural responses.

Concentration- and time-dependence of phosphorylation events stimulated by fibroblast growth factor-4 (FGF-4) in Rama 27 fibroblasts

This study examines how FGF-4 concentration and time affect phosphorylation of FRS2, MAPK1, and MAPK3 in Rama 27 fibroblasts, revealing oscillatory and bell-shaped responses at different concentrations.

FGF21 signals through KLB-expressing glutamatergic neurons in the hindbrain to mediate the effects of dietary protein restriction

The paper identifies NTS-KLB glutamatergic neurons as critical for mediating FGF21's effects during dietary protein restriction, showing their role in metabolic and behavioral adaptations.

Dietary amino acid manipulations in the common marmoset Callithrix jacchus impacts serum metabolites and FGF21 levels

The paper shows that dietary amino acid manipulation in marmosets affects serum metabolites and FGF21 levels, suggesting evolutionary conservation of the mechanism.

Sex-specific metabolic responses to modulation of the glucagon-FGF21 axis in female mice

This study examines sex-specific metabolic effects of FGF21 deficiency and glucagon analog treatment in female mice, revealing exacerbated obesity and altered glucose tolerance in females.

The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21

This study shows halofuginone, an FDA-approved drug, reduces obesity in mice by increasing FGF21 and GDF15 levels, improving metabolic health.

Relationship Between Circulating FGF21 and Bone Mineral Density: An Exploratory Study

This study explores the relationship between circulating FGF21 and bone mineral density, finding a significant negative correlation in females but not males.

ASK1 overexpression protects from HFD-induced body weight gain via FGF21

This study shows that liver-specific ASK1 overexpression protects against HFD-induced obesity and improves glucose metabolism via increased FGF21 production.

Relationship Between Circulating FGF21 and Physiological and Lifestyle Characteristics, an Exploratory Study

This study explores the relationship between circulating FGF21 and lifestyle factors, finding correlations with sleep, diet, and blood urea nitrogen levels in healthy humans.

FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling

This study shows that FGF21 in the brain enhances the reward value of protein, increasing motivation to consume it during protein restriction.

Ribosomal Biogenesis Hyperactivation and ErbB signalling Mediated Network Rewiring Causes Adaptive Resistance to FGFR2 Inhibition

This study identifies ribosomal biogenesis hyperactivation and ErbB signaling reactivation as mechanisms of resistance to FGFR2 inhibitors in breast cancer cells and shows synergy with MEK inhibitors.

Diverse Fgfr1 signaling pathways and endocytic trafficking regulate early mesoderm development

This study identifies diverse Fgfr1 signaling pathways and endocytic trafficking mechanisms that regulate early mesoderm development, revealing both canonical and non-canonical roles beyond traditional signaling cascades.

FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development

The paper shows that GRB2 binding to the C-terminal of FGFR2, independent of FRS2, is not essential for embryonic development or adult homeostasis.

Mixed data analysis detected Endocrine Fibroblast Growth Factors (FGF19, FGF21, and FGF23) as Prognostic and Diagnostic Markers of Colorectal Neoplasia and Carcinoma

Elucidating Fibroblast Growth Factor-induced kinome dynamics using targeted mass spectrometry and dynamic modeling

The paper quantifies kinase activity dynamics in response to FGF ligands and uses dynamic modeling to reveal pathway regulation and novel kinase involvement.