Phagocytosis and Immune Regulation

CD47 blockade augments anti-GD2 driven phagocytosis in vitro but fails to improve in vivo efficacy in immune competent, chemoresistant neuroblastoma preclinical models

This study shows CD47 blockade enhances anti-GD2 phagocytosis in vitro but does not improve in vivo efficacy in neuroblastoma models.

Transient efferocytosis-induced activation of IKKβ reprograms macrophages to promote tissue resolution

This study identifies IKKβ activation as a transient upstream signal triggered by efferocytosis that promotes tissue resolution through multiple downstream pathways.

Myo1e/f regulate phagocytic podosomes to promote efficient cup closure in macrophages

This study shows that Myo1e/f regulate phagocytic podosomes and the phagocytic ring to ensure efficient cup closure in macrophages.

Efferocytosis Remodels Osteoclast Metabolism and Enhances Antibacterial Defense

This study shows that osteoclast efferocytosis enhances antibacterial defense by remodeling metabolism through glycolytic activity and lactate handling.

Apoptotic Cells Promote Tim4+ Macrophage Differentiation Through Direct and Indirect Signaling Pathways

This study shows that apoptotic cells promote Tim4+ macrophage differentiation through both direct and indirect signaling pathways involving efferocytosis and IL-4R-STAT6 signaling.

Macrophages discriminate and sort pathogenic bacteria and apoptotic material during dual-target phagocytosis

This study shows macrophages can distinguish and sort pathogenic bacteria and apoptotic material during phagocytosis, using distinct engulfment strategies.

Structural basis of phosphatidylserine enhancement of Gas6 ligand-induced Axl activation

The paper presents structures of TAM receptor-ligand complexes with and without lipid, showing lipid stabilizes active complexes and provides a mechanism for TAM receptor activation.

CD300a Blockade attenuates renal fibrosis by enhancing macrophage efferocytosis and neutrophil MMP9 production

This study shows that blocking CD300a reduces renal fibrosis by improving macrophage efferocytosis and increasing neutrophil MMP9 production.

A Multiscale Signaling--Biophysical Framework Reveals Mechanisms of Macrophage-Mediated RBC Clearance in Sickle Cell and Gaucher Disease

This paper develops a multiscale modeling framework to study macrophage-mediated RBC clearance in sickle cell disease and Gaucher disease, revealing altered signaling and biophysical mechanisms.

N-aldehyde modified phosphatidylethanolamines formed by lipid peroxidation inhibit efferocytosis.

This study shows that N-aldehyde modified phosphatidylethanolamines (NAMPs) inhibit efferocytosis and are elevated under oxidative stress conditions.

A Distal Super-Enhancer Regulate CD47 Expression and Promotes Macrophage-Mediated Phagocytosis of Ovarian Cancer Cells

The paper identifies a distal super-enhancer regulating CD47 expression in ovarian cancer, linking it to macrophage-mediated phagocytosis of cancer cells.

Gpnmb-positive lipid-associated macrophages contribute to lipid clearance during luteolysis

This study identifies Gpnmb+ macrophages in mouse and human ovaries that specialize in lipid clearance during luteolysis, resembling adipose tissue lipid-associated macrophages.

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance

The paper shows that de novo E-cadherin/catenin complex formation at the phagocytic synapse regulates epithelial mechanics and force transmission for apoptotic cell clearance in zebrafish and mouse.

Temporal and Age-Dependent Regulation of Phagocytosis-Related Signatures After Ischemic Stroke: Cross-Species Transcriptomic Evidence

This study identifies conserved post-stroke immune responses across mice and humans, showing that aging impairs efferocytosis and promotes inflammation, suggesting it as a therapeutic target.

Cytokinesis Arrest-induced Binucleation of Macrophages ProducesHighly Efficient Efferocytes

The paper shows that cytokinesis arrest in macrophages leads to binucleation, which enhances efferocytic function and reduces autoimmune responses.

Immunomodulatory mechanisms of submicron phosphatidylserine-exposing polymeric particles (PSPs)

This study develops submicron phosphatidylserine-exposing polymeric particles (PSPs) that modulate macrophage activity by reducing inflammation and promoting resolution through redox adaptation and suppression of inflammatory signaling.

Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Breast Cancer

This study identifies non-immunological, pro-tumorigenic roles of CD47 in DLBCL and TNBC, showing context-dependent effects on metabolism, proliferation, and drug response.

An immune-stimulating antibody conjugate spatiotemporally targeting CD47 and TLR9 elicits macrophage-dependent tumor clearance and durable anti-cancer adaptive immunity

This paper develops an antibody conjugate targeting CD47 and TLR9 that enhances macrophage activity and induces durable anti-cancer immunity in tumor models.

Apoptotic bodies from patients with Sjogren's disease drive atypical memory B cell and macrophage activation and autoantibody production

The paper compares apoptotic bodies from Sjogren's disease patients and healthy donors, showing they drive B cell and macrophage activation and autoantibody production.

Digest before Ingest: Early Recruitment of Membrane-bound DNaseX to Phagocytic Cups in Macrophages

The paper identifies early membrane-bound DNaseX activity at phagocytic cups in macrophages, enabling extracellular DNA degradation without internalization.

Conserved role of EGFR signaling in apoptotic cell recognition and processing across different phagocytes

This study shows EGFR signaling is essential for efferocytosis in C. elegans and zebrafish, with EGF acting as an engulfment signal.

The engulfment receptor CED-1/MEGF10 activates the GPCR LAT-1/ADGRL3 for apoptotic cell degradation

This study identifies a conserved signaling pathway involving CED-1/MEGF10 and LAT-1/ADGRL3 that regulates apoptotic cell clearance through a transcriptional cascade.

SPIC-dependent erythrophagocytic macrophages drive granuloma formation and pathogen persistence during intracellular bacterial infection

The paper identifies SPIC-dependent VCAM1+ macrophages as drivers of granuloma formation and bacterial persistence during Salmonella infection.

A Geometric Model of Nucleus-Constrained Frustrated Phagocytosis

The paper develops a geometric model to explain how the nucleus limits phagocytosis by deriving quantitative relationships between target geometry and nuclear exclusion.

Draper-mediated efferocytosis by Drosophila imaginal disc epithelial cells clears cellular debris during regeneration.

The paper shows that Drosophila epithelial cells clear debris during wing disc regeneration via Draper-mediated efferocytosis without immune cell involvement.

Upregulation of PD-L1 as a putative mechanism of resistance to CD47 inhibition in non-small cell lung cancer

This study shows that PD-L1 upregulation mediates resistance to CD47 inhibition in lung cancer, and dual inhibition of CD47 and PD-L1 improves survival in mouse models.

CD47 Blockade Reprograms the Monocyte-Macrophage Axis to Promote Inflammation Resolution in Atherosclerosis

This study shows CD47 blockade reprograms the monocyte-macrophage axis in atherosclerosis, reducing inflammation and enhancing apoptotic cell clearance.

Dysregulation of "Don't Eat Me" Signaling-Related Genes in Sepsis: A Targeted Transcriptomic Analysis

This study identifies dysregulated 'Don't Eat Me' signaling genes in sepsis using transcriptomic analysis, revealing potential therapeutic targets.

Reg3β removes aged neutrophils after myocardial infarction

This study identifies REG3β as a factor that removes aged neutrophils after myocardial infarction, promoting inflammation resolution and cardiac repair.

Macrophage Phagocytic Impairment is associated with Dysbiosis of the Respiratory Microbiome in Frail older adults

This study finds that frail older adults have impaired macrophage phagocytosis and a less diverse respiratory microbiome, which may be linked to PPARγ pathway dysfunction.