Anesthesia and Neurotoxicity Research

Sex-dependent chronic neurological dysfunction following isoflurane anesthesia and surgery is associated with circulating extracellular vesicle-mediated neuroinflammatory signaling

This study shows that isoflurane anesthesia and surgery cause chronic sex-dependent neurological issues in mice, linked to changes in brain transcriptomes and circulating extracellular vesicles.

Isoflurane and surgery aggravate APOE4-dependent lipid dysregulation and neural dysfunction, leading to neurological impairment in male mice

This study shows that isoflurane anesthesia and surgery worsen lipid dysregulation and neural dysfunction in APOE4 mice, leading to neurological impairments.

Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats

This study identifies hippocampal mitochondrial dysfunction as a key mechanism underlying opioid-induced postoperative cognitive dysfunction in aged rats and shows that mitochondrial rejuvenation can reverse memory deficits.

Brief, repeated isoflurane anaesthesia elicits sex-dependent behavioural, cerebrovascular, and microglial alterations in mice

This study shows that repeated brief isoflurane anaesthesia causes sex-dependent behavioural, cerebrovascular, and microglial changes in mice.

Corticosterone-linked microglial activity underpins sexually dimorphic neuroplasticity after ketamine anesthesia.

The paper identifies a female-selective corticosterone-mediated microglia-neuron interaction during ketamine anesthesia recovery that drives neuronal plasticity.

In vivo changes in zebrafish anesthetic sensitivity in response to the loss of kif5Aa are associated with the alteration of mitochondrial motility

This study shows that loss of kif5Aa in zebrafish alters anesthetic sensitivity and mitochondrial motility in response to propofol, etomidate, and dexmedetomidine.

Pre-anaesthetic anxiety phenotype stratifies cortical excitability, learned navigation, and post-anaesthetic sleep in sevoflurane-exposed mice

The paper identifies pre-anaesthetic anxiety as a factor affecting cortical excitability, navigation, and post-anaesthetic sleep in mice exposed to sevoflurane.

Altered Brain Energy Metabolism in the APPPS1 Alzheimer's Model during anesthesia: Integration of Experimental Data and In Silico Modeling

The paper investigates how anesthetic exposure affects brain energy metabolism in an Alzheimer's model, showing reduced oxidative metabolism and worsened potassium regulation in diseased tissue.

Synchronized Chromatin Organization Serves as Potent Biomarker in Anaesthesia-based Plant Consciousness

This study investigates the effects of anaesthesia on plant root and stem cells, finding that synchronized chromatin organization serves as a biomarker for conscious awareness in plants.

ATF5-Dependent GDF15 Expression Mediates Anesthesia-Induced Neuroprotection Against Stroke

This study shows sevoflurane-induced neuroprotection against stroke involves ATF5 and GDF15, but this pathway is inactive in aged mice.

A Hierarchical Cascade of Organellar Silencing and their Regeneration under Anaesthetic Stress in Plants

This study shows that plant cells exposed to lidocaine for up to four hours can recover from anaesthetic stress, but prolonged exposure leads to irreversible nuclear damage and cell death.

Isoflurane and Surgical Stress Disrupt Fatty Acid and Carbon Metabolism Leading to Cardiomyopathy

This study shows isoflurane and surgical stress cause age-dependent cardiac metabolic and structural changes leading to cardiomyopathy.

Myelin Decompaction in Mice Given Anesthetics during Magnetic Resonance Imaging

The paper examines if prolonged anesthetic exposure during MRI increases myelin decompaction in mice, finding significantly higher proportions in anesthetized mice.

Direct Visualization of Anesthesia-induced Subcellular Dysfunction in Non-Neuronal Tissues of C. elegans

This study investigates the subcellular effects of anaesthetics on non-neuronal tissues using human cell lines and C. elegans, revealing mitochondrial and lysosomal dysfunction, oxidative stress, and transcriptional changes.

Bridging Stem Cell Models and Medicine: Integrated 3D Human Cerebral Organoids and Pediatric Serum Reveal Mechanisms and Biomarkers of Anesthetic-Induced Neurotoxicity

This study uses 3D human cerebral organoids and pediatric serum to identify molecular signatures of anesthetic-induced neurotoxicity, revealing shared dysregulated RNAs linked to neuronal injury and neurodevelopmental disruption.

Ciliopathy interacts with neonatal anesthesia to cause non-apoptotic caspase-mediated motor deficits

The paper shows that ciliopathy and neonatal ketamine exposure interact to cause motor deficits through non-apoptotic caspase activation, which can be reversed by caspase inhibition.

Suberoylanilide Hydroxamic Acid Attenuates Cognitive Impairment in Offspring Caused by Maternal Surgery during Mid-pregnancy

This study shows that SAHA reduces cognitive deficits in offspring caused by maternal propofol exposure and surgery during mid-pregnancy by modulating histone acetylation and related proteins.

Similarity and dissimilarity in alteration of gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane

This study compares the effects of sevoflurane and desflurane on liver gene expression profiles in rats, finding similar gene activation and differential repression of cholesterol biosynthesis-related genes.

Microglia facilitate and stabilize the response to general anesthesia

This study shows that microglia facilitate and stabilize the general anesthesia response by activating P2Y12 and calcium influx, without involving dendritic spine plasticity.

Multiple exposures to sevoflurane during the neonatal period impair hippocampus development and cognitive function in young mice

This study shows that repeated neonatal sevoflurane exposure impairs hippocampal development and cognitive function in mice through altered gene expression and synaptic dysfunction.

Neonatal exposures to sevoflurane in rhesus monkeys alter synaptic ultrastructure in later life

This study shows that early-life sevoflurane exposure in rhesus monkeys leads to long-term synaptic ultrastructural changes in the hippocampus and prefrontal cortex.

Propofol Reverses Surgery-Induced Neuroinflammation and Cognitive Impairment in Aged Mice via α5-GABAA Receptors

This study shows that propofol reduces surgery-induced neuroinflammation and cognitive deficits in aged mice through α5-GABAA receptors.

Changes of oscillatory and aperiodic neuronal activity in working memory following anaesthesia: a prospective observational study

This study examines changes in oscillatory and aperiodic neuronal activity in working memory after anaesthesia and finds distinct EEG signatures linked to cognitive performance.

Annexin-A1 tripeptide attenuates surgery-induced neuroinflammation and memory deficits through regulation of the NLRP3 inflammasome

This study investigates the role of the NLRP3 inflammasome in postoperative neuroinflammation and evaluates the neuroprotective effects of the ANXA1-derived peptide ANXA1sp in a mouse model of surgery-induced cognitive deficits.

A common human brain-derived neurotrophic factor polymorphism leads to sustained depression of excitatory synaptic transmission by isoflurane in hippocampus

The paper shows that a BDNF polymorphism (Val66Met) leads to persistent depression of excitatory synaptic transmission after isoflurane exposure in mice.

Exposure to sevoflurane results in changes of transcription factor occupancy in sperm and inheritance of autism

Exposure to sevoflurane in pregnant mice leads to behavioral impairments in F1 offspring, which are transmitted to F2 and F3 generations through altered transcription factor occupancy in sperm.

Prolonged anesthesia alters brain synaptic architecture

This study shows prolonged anesthesia in mice leads to cognitive impairment and altered synaptic turnover in the cortex, with increased synapse formation during anesthesia and loss afterward.

BAX is necessary for neuronal death following exposure to isoflurane during the neonatal period

This study shows that BAX is required for isoflurane-induced neuronal death in neonates, with GABAergic interneurons being selectively vulnerable and neuroinflammation secondary to apoptosis.

Transcriptome analysis of sevoflurane exposure effects at the different brain regions

This study identifies KLF4 as a potential transcriptional regulator of angiogenesis and neural development in sevoflurane-exposed mice brains.

A synthetic peptide rescues rat cortical neurons from anesthetic-induced cell death and modulation of growth and synaptic assembly

This study shows a synthetic peptide protects rat cortical neurons from anesthetic-induced damage by reversing mitochondrial fission.