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This study shows that TCA cycle turning is not essential for stem and progenitor cell survival or proliferation and its loss enhances stem cell function in hematopoiesis.

The paper identifies marine sulfated glycans that inhibit Borrelia burgdorferi adhesins' binding to heparin/GAGs, with specific inhibitors showing varying potency against different adhesins.

This paper identifies a helix 8-proximate allosteric site in GPR84 and shows how it enables Gi-biased signalling through structural and dynamic mechanisms.

This study uses multimodal 3D imaging to show that lysosomes dissolve cholesterol crystals in macrophages, with cyclodextrin enhancing this process.

This study identifies a histidine-mediated pendulum mechanism in [FeFe]-hydrogenases that enhances catalytic activity by facilitating proton transfer.

This study analyzes the structural and biochemical properties of BtuG homologs in B. thetaiotaomicron to understand their role in cobalamin scavenging.

FAST-MaP provides a protocol for per-nucleotide RNA structure characterization using chemical modification and primer-less sequencing without requiring sequencing infrastructure or bioinformatics expertise.

This study identifies anti-SDMA autoantibodies in SLE patients, showing they target methylated arginine motifs in self and viral proteins and correlate with disease activity.

ERRORROUTE improves 3D medical image segmentation by selectively allocating computation to regions where additional processing provides the most utility, achieving higher accuracy with lower computational cost.

The paper identifies and characterizes nitrate-binding affinity differences in staphylococcal NreA homologues, showing that a conserved binding pocket allows recognition while distal sequence variation tunes affinity.

This paper introduces two modified CHAMP-N methods to extend N-terminal peptide length, improving N-terminome coverage while maintaining technical reproducibility.

This study identifies IDHA-1 as a barrier to direct reprogramming of germ cells to neurons in C. elegans, showing metabolic and epigenetic mechanisms that maintain germ cell identity.

This study identifies a conserved SPP-like phosphatase in cyanobacteria that can dephosphorylate sucrose 6-phosphate and 3-phosphoglycerate, suggesting broader substrate specificity than canonical SPP proteins.

This study maps the luminal proteome of the ER and Golgi in T. brucei using TurboID proximity biotinylation, identifying TbMANF as a novel modulator of ER stress tolerance in African trypanosomes.

This study uses middle-down phosphoproteomics to analyze how protein partitioning into biomolecular condensates changes under proteostatic stress, revealing phosphorylation-dependent and independent mechanisms.

This study shows that chemical modifications to siRNA and linkers in AOCs can improve potency and tissue targeting while allowing higher payload loading.

This study uses three orthogonal chemical proteomic strategies to identify 495 cholesteryl ester-associated proteins in mammalian cells, revealing their functional and disease relevance.

This study shows phosphorylation of Thr552 in Kv7.4 reduces PIP2 binding and channel activity while reorganizing calmodulin interactions.

This study characterizes the interaction between PQLC2 and the WDR41 7CD loop using EPR spectroscopy, revealing structural and dynamic insights into their binding mechanism.

The paper identifies an N-terminal acetylated degron recognized by the CTLHMKLN1-FAM72A E3 ubiquitin ligase, revealing a specific motif and molecular mechanism for proteasomal degradation.