Discover, rate, and discuss biology preprints.

The paper develops a platform for automated vessel-on-chip fabrication and a generative AI model, CLoT, to predict thrombosis in patients with high accuracy.

This paper introduces an animal-origin-free method for generating blood vessel organoids using a single-layer 'sitting drop' culture system, achieving reproducible morphology and successful in vivo integration.

This paper introduces a new in vivo technique, transient magnetic resonance elastography (tMRE), to measure dynamic cardiac biomechanics and validates it using healthy rat specimens and phantom experiments.

This study shows that methyl palmitate nanoparticles enhance tumor perfusion and nanomedicine delivery by inducing vasodilation and reducing phagocytosis.

This paper develops a kinetic model for CRISPR-Cas-based autocatalytic assays to improve understanding and design of target-amplification-free systems.

This study compares knee and hip joint dynamics during sprinting and Nordic hamstring exercises, finding differences in biomechanical demands and hamstrings muscle-tendon unit behavior.

This paper introduces fOCTA-rNVC, a functional OCT angiography method that detects premotor Parkinson's disease by measuring retinal capillary neurovascular coupling changes, achieving 100% accuracy with minimal midbrain dopaminergic neuron loss.

This paper develops a Raman spectroscopy method to rapidly and accurately quantify residual immunomagnetic beads in cell therapy manufacturing.

The paper presents an open-source liquid-handling robot designed for custom, high-throughput biological experiments, validated with a turbidostat workflow.

The paper evaluates the developability of single-domain antibody chelator conjugates for diagnostic radiotracers using stability and functional assays.

This paper introduces a computational framework for designing vascular networks in biohybrid tissues, enabling 3D-printing of complex, hierarchical vasculature with biological and synthetic constraints.

This paper develops FeSA+NC nanozymes with enhanced catalase-like activity and selectivity for anti-inflammatory therapy through spin-state modulation by atom-cluster synergy.

The paper develops INSITE, an injectable platform for hepatocyte transplantation that enables precise delivery and long-term function through image-guided assembly into vascularizable scaffolds.

This paper introduces a system for functionalizing extracellular vesicles with nanobody adapters, enabling flexible and efficient attachment of target proteins without genetic engineering of cells.

This paper introduces GEMINI, a tool that records cellular activity histories with high temporal resolution, and demonstrates its application in tracking transcriptional changes and inflammation dynamics in vivo.

This study uses adipose-mimetic hydrogels to show that soft mechanical cues from adipocytes enhance breast cancer cell invasion by altering ECM structure and cellular confinement.

Across nearly one million progeny from 10 species, species best predicts homing drive inheritance, while promoter, parent sex and maternal deposition each explain little of the inheritance variation.

The paper demonstrates successful gene editing in sand flies using CRISPR-Cas9 and PiggyBac to target olfactory and non-lethal phenotypic genes.

This paper develops a multi-frequency laparoscopic SFDI framework to improve optical property estimation in layered tissue for chemophototherapy treatment planning.

This paper introduces single-capture qOBM, a deep learning-enhanced technique for fast, label-free 3D phase imaging, achieving accuracy comparable to traditional methods with improved speed and simplicity.