Teodor E. Yordanov

This paper introduces an animal-origin-free method for generating blood vessel organoids using a single-layer 'sitting drop' culture system, achieving reproducible morphology and successful in vivo integration.

This study shows integrin β1-Talin1 at focal adhesions drive uncontrolled endothelial cell enlargement in CCM vasculature, independent of KLF2/4.

This study shows that c-Src activation in endothelial cells causes vascular expansion through focal adhesion signaling and localized matrix degradation, which can be inhibited to prevent abnormal vascular growth.